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Longevity: importance of Klotho gene polymorphisms and hematologic data

Abstract

Longevity is a topic that causes a lot of interest and the factors associated with risk of disability and death are really important to the understanding of this process. However, longevity is still poorly understood and more studies are necessary. Objective: To evaluate if there is association between polymorphisms rs9536314, rs564481 and rs1207568 of Klotho gene and longevity. To estimate, in accordance with criteria established by WHO, the frequency and characteristics of anemia in a population of community-dwelling very older adults. Methods: A cross sectional study of 250 individuals, 80 years old or older, with functional independence, in the Outpatient service of Geriatrics department of UNIFESP and 500 healthy individuals, blood donators from UNIFESP Blood Center (control group). Participants respond to the questionnaire administered by physicians and will be submitted to laboratory exams through venipuncture. Tests that will be performed are: complete blood count, urea, creatinine, C-reactive protein, iron, ferritin, transferrin soluble receptor, hepcidin, lactic dehydrogenase, TSH, free T4, folic acid and vitamin B12, and analysis of polymorphisms rs9536314, rs564481 and rs1207568 of Klotho gene. The data collected and the results will be statistically analyzed. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NIELE SILVA DE MORAES; MARIA STELLA FIGUEIREDO. Challenges in the diagnosis of iron deficiency anemia in aged people. Revista Brasileira de Hematologia e Hemoterapia, v. 39, n. 3, p. -, Set. 2017.

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