Research Grants 13/04656-8 - Degradação de resíduos químicos, Toxicidade - BV FAPESP
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Degradation of pharmaceuticals by peroxidation combined with ultraviolet radiation and ozonation: antimicrobial activity and toxicity

Abstract

Sulfonamide is a group of synthetic antimicrobials containing over 150 sulfas, which act on the nucleic acids of target microorganisms inhibiting their growth. Since 1982, they have been detected in water bodies from various countries such as the USA, France and China. Fluoroquinolones are commonly used in veterinary medicine as antibacterial agents. Tetracycline is the second most common group of antibiotics in the world both in production volume and use; it is used to treat diseases in human beings and livestock. Most of the administered drugs are excreted via urine and/or feces. Therefore, these drugs are often found in wastewater treatment plants, natural waters and groundwater in the range of µg L-1 and ng L-1. Due to their constant introduction into the environment and their poor natural degradation in aqueous media, these pharmaceuticals are considered persistent and their presence in the environment may contribute to the development of resistant bacteria. Currently, there are few available studies evaluating the degradation of sulfaquinoxaline, doxycycline, gatifloxacin and lomefloxacin by ozonation and advanced oxidation processes. In the proposed study, it will be evaluated the efficiency of photolysis, peroxidation, peroxidation combined with ultraviolet radiation and ozonation to degrade and remove antimicrobial activity and toxicity of drugs in aqueous solutions. The drugs to be evaluated belong to sulfonamide (sulfaquinoxaline), tetracycline (doxycycline) and fluoroquinolones (gatifloxacin and lomefloxacin) classes. Finally, the intermediates formed during the degradation processes will also be investigated and proposed. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
URBANO, VANESSA RIBEIRO; MANIERO, MILENA GUEDES; PEREZ-MOYA, MONTSERRAT; GUIMARAES, JOSE ROBERTO. Influence of pH and ozone dose on sulfaquinoxaline ozonation. Journal of Environmental Management, v. 195, n. 2, SI, p. 224-231, . (13/04656-8, 14/06201-0, 13/07817-2, 13/09543-7, 14/06064-3)
GRACA, CATIA A. L.; FUGITA, LUCAS T. N.; DE VELOSA, ADRIANA CORREIA; TEIXEIRA, ANTONIO CARLOS S. C.. Amicarbazone degradation promoted by ZVI-activated persulfate: study of relevant variables for practical application. Environmental Science and Pollution Research, v. 25, n. 6, SI, p. 5474-5483, . (13/09543-7, 13/04656-8, 13/50218-2)
SPINA-CRUZ, MYLENA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Advanced oxidation processes on doxycycline degradation: monitoring of antimicrobial activity and toxicity. Environmental Science and Pollution Research, v. 26, n. 27, SI, p. 27604-27619, . (13/07817-2, 13/09543-7, 13/04656-8)
SPINA-CRUZ, MYLENA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Advanced oxidation processes on doxycycline degradation: monitoring of antimicrobial activity and toxicity. Environmental Science and Pollution Research, v. 26, n. 27, p. 16-pg., . (13/04656-8, 13/07817-2, 13/09543-7)
DUARTE DE OLIVEIRA, AMANDA MARCHI; MANIERO, MILENA GUEDES; RODRIGUES-SILVA, CAIO; GUIMARAES, JOSE ROBERTO. Antimicrobial activity and acute toxicity of ozonated lomefloxacin solution. Environmental Science and Pollution Research, v. 24, n. 7, p. 6252-6260, . (13/04656-8, 13/09543-7, 13/07817-2, 14/16622-3)
RIBEIRO URBANO, VANESSA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO; DEL VALLE, LUIS J.; PEREZ-MOYA, MONTSERRAT. Sulfaquinoxaline Oxidation and Toxicity Reduction by Photo-Fenton Process. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 18, n. 3, . (13/09543-7, 13/04656-8, 13/07817-2)
URBANO, VANESSA RIBEIRO; PERES, MARCELA SOUZA; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Abatement and toxicity reduction of antimicrobials by UV/H2O2 process. Journal of Environmental Management, v. 193, p. 439-447, . (13/04656-8, 13/09543-7, 13/07817-2)
CAIANELO, MARLON; RODRIGUES-SILVA, CAIO; MANIERO, MILENA GUEDES; GUIMARAES, JOSE ROBERTO. Antimicrobial activity against Gram-positive and Gram-negative bacteria during gatifloxacin degradation by hydroxyl radicals. Environmental Science and Pollution Research, v. 24, n. 7, p. 6288-6298, . (14/16622-3, 14/06064-3, 13/09543-7, 13/04656-8, 13/07817-2, 14/06201-0)
GRACA, CATIA A. L.; MANIERO, MILENA GUEDES; DE ANDRADE, LIDIANE MARIA; GUIMARAES, JOSE ROBERTO; TEIXEIRA, ANTONIO CARLOS S. C.. Evaluation of amicarbazone toxicity removal through degradation processes based on hydroxyl and sulfate radicals. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, v. 54, n. 11, . (13/09543-7, 13/07817-2, 13/50218-2, 13/04656-8)
DE OLIVEIRA, AMANDA M. D.; MANIERO, MILENA G.; GUIMARAES, JOSE R.. Lomefloxacin Degradation: Antimicrobial Activity, Toxicity and Byproducts. JOURNAL OF ADVANCED OXIDATION TECHNOLOGIES, v. 18, n. 2, p. 211-220, . (13/07817-2, 13/09543-7, 13/04656-8)
URBANO, VANESSA RIBEIRO; MANIERO, MILENA GUEDES; PEREZ-MOYA, MONTSERRAT; GUIMARAES, JOSE ROBERTO. Influence of pH and ozone dose on sulfaquinoxaline ozonation. Journal of Environmental Management, v. 195, p. 8-pg., . (14/06064-3, 13/04656-8, 13/09543-7, 14/06201-0, 13/07817-2)
GRACA, CATIA A. L.; FUGITA, LUCAS T. N.; DE VELOSA, ADRIANA CORREIA; TEIXEIRA, ANTONIO CARLOS S. C.. Amicarbazone degradation promoted by ZVI-activated persulfate: study of relevant variables for practical application. Environmental Science and Pollution Research, v. 25, n. 6, p. 10-pg., . (13/09543-7, 13/04656-8, 13/50218-2)

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