Influence of aerobic exercise on the expression and distribution of microRNAs in the hippocampal formation of adult rats

• Grant number: 13/12692-4
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2013
• End date: September 30, 2015
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Ricardo Mario Arida
• Grantee: Ricardo Mario Arida
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Andre Schwambach Vieira ; Iscia Teresinha Lopes Cendes

Abstract

The scientific literature has extensively documented the beneficial effects of physical exercise on brain function. Physical exercise has the ability to improve the cognitive function, decrease age-related memory loss, delay the onset of neurodegenerative diseases, facilitate recovery after brain injury and improve depressive symptoms. MicroRNAs (miRNAs) are small, non-coding RNAs of approximately 23 nucleotides that act as potent silencers of gene expression by inducing translational repression or degradation of target mRNA. miRNAs regulate the expression of genes involved in several biological processes, such as cell cycle, apoptosis, and cell differentiation. These molecules are abundantly present in the adult brain and have a spatiotemporal expression pattern. The neurobiological role of these molecules in processes such as brain development, aging, injury, cognition and neurological disorders, has received more attention only in recent years. Considering the key role of this noncoding RNAs on post-transcriptional control of gene expression, and the positive influence that physical exercise promotes on brain function, the present study aims to investigate the effects of acute, short and long-term aerobic exercise on expression and distribution of miRNAs in the hippocampus of adult rats. The results of this study can help us to understand the complexity of the mechanisms underlying the exercise-induced improvement on brain function, and may contribute to identifying potential therapeutic targets for the treatment of several neurological diseases. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE ALMEIDA, ALEXANDRE APARECIDO; DA SILVA, SERGIO GOMES; LOPIM, GLAUBER MENEZES; CAMPOS, DIEGO VANNUCCI; FERNANDES, JANSEN; CABRAL, FRANCISCO ROMERO; ARIDA, RICARDO MARIO. Resistance Exercise Reduces Seizure Occurrence, Attenuates Memory Deficits and Restores BDNF Signaling in Rats with Chronic Epilepsy. Neurochemical Research, v. 42, n. 4, p. 1230-1239, APR 2017. (13/12692-4, 11/50680-2, 14/00035-1)

DE ALMEIDA, ALEXANDRE APARECIDO; DA SILVA, SERGIO GOMES; LOPIM, GLAUBER MENEZES; CAMPOS, DIEGO VANNUCCI; FERNANDES, JANSEN; CABRAL, FRANCISCO ROMERO; ARIDA, RICARDO MARIO. Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy. Journal of Neuroscience Research, v. 96, n. 5, p. 911-920, MAY 2018. (13/12692-4, 14/00035-1, 13/13725-3, 11/50680-2)

FERNANDES, JANSEN; ARIDA, RICARDO MARIO; GOMEZ-PINILLA, FERNANDO. Physical exercise as an epigenetic modulator of brain plasticity and cognition. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 80, p. 443-456, SEP 2017. (13/12692-4, 15/09234-0, 13/13725-3)

SCHOR, B.; GOMES DA SILVA, S.; DE ALMEIDA, A. A.; PEREIRA, C. A. B.; ARIDA, R. M.. Plasma brain-derived neurotrophic factor is higher after combat training (Randori) than incremental ramp test in elite judo athletes. Brazilian Journal of Medical and Biological Research, v. 52, n. 4, 2019. (13/12692-4, 11/50680-2)