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Interfacial chemistry: drugs, peptides and ezymes interactions with membrane models

Grant number: 13/08166-5
Support type:Research Projects - Thematic Grants
Duration: November 01, 2013 - October 31, 2019
Field of knowledge:Biological Sciences - Biophysics
Principal Investigator:Iolanda Midea Cuccovia
Grantee:Iolanda Midea Cuccovia
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Fábio Herbst Florenzano ; Hernan Chaimovich Guralnik
Assoc. researchers: Dominik Horinek ; Luis Gustavo Dias ; Luiz Juliano Neto ; Magali Aparecida Rodrigues ; Marcelo Porto Bemquerer ; Maria Aparecida Juliano ; Maria de La Salette de Freitas Fernandes Hipólito Reis Dias Rodrigues ; Maria Lucia Bianconi ; Roberto Kopke Salinas ; Sandro Roberto Marana ; Wanderley Dantas dos Santos
Associated grant(s):15/10411-3 - Multi-User Equipment, previously approved in grant 2015/08166-5: stopped-flow, AP.EMU
Associated scholarship(s):19/05484-2 - Synthesis of a copolymer via RAFT with variable composition gradient using ACOMP and an automatic controller of polymerizations, BE.PQ
19/03023-8 - How do cell penetrating peptides enter cells?, BP.DD
18/19838-8 - Decisive forces for the structure and stability of aggregates composed by synthetic surfactants: ion association selectivity to interfaces and vesicle formation, BP.DD
+ associated scholarships 18/15230-5 - Antibacterial and anticancer activities of BP100 peptide and analogs containing Naphathalimide, BP.PD
18/05516-9 - Copolymers of polystyrene and poly(2-(dimethylamino)ethyl methacrylate) designed as building blocks for nanoreactors - second part, BP.IC
17/02463-9 - Copolymers of polystyrene and poly(2-(dimethylamino)ethyl methacrylate) designed as building blocks for nanoreactors, BP.IC
16/00709-8 - Interfacial chemistry: drugs, peptides and ezymes interactions with membrane models, BP.PD - associated scholarships

Abstract

Using micelles and vesicles as models we will focus questions representing new frontiers in the study of interfacial properties using methods we have used for decades and deploying new techniques in collaboration with researchers from Brazil and abroad. Can we design (synthesize) self-aggregating surfactants that form vesicles capable of catalyzing and self-replicate? What is the role of lipid bilayer asymmetry in the properties and selective adsorption of ions or on the electrostatic properties of membranes? How can this selective binding of ions influence membrane / peptide interactions? How are ions are distributed within vesicles? What is the mechanism of association of the triflate ion in micelles and what does this tell us about ion association to interfaces? Using the dediazoniation reaction of substituted diazobenzenes can we design a nucleophilicity scale relevant to biological systems and determine ideality in solvent mixtures? How do mixed polymers aggregate and catalyze? How does human paraoxonase and asparaginase behave when interacting with membranes? What is the mechanism of interaction of BP100, a semisynthetic undecapeptide, with membranes? Can new imidazole derivatives and anti-inflammatory compounds be efficiently incorporated in liposomes? The answers to these questions, which are part of a line of thought of our group, will bring fundamental and applied contributions in the area of biomimetic systems. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Bactericidal action of violacein revealed 
Articles published in other midia outlets (15 total):
More itemsLess items
Bactericidal Action of Violacein Revealed 
Bactericidal action of violacein revealed 
Revelado el mecanismo de acción bactericida de la violaceína 
Revelado el mecanismo de acción bactericida de la violaceína 
Bactericidal action of violacein revealed 
Revelado el mecanismo de acción bactericida de la violaceína 
Bactericidal action of violacein revealed 
Bactericidal action of violacein revealed 
Bactericidal action of violacein revealed 
Bactericidal action of violacein revealed 
Bactericidal action of violacein revealed 
Brazilian researchers reveal bactericidal action mechanism of violacein 
Bactericidal action of violacein revealed 
Bactericidal action of violacein revealed 
Bactericidal action of violacein revealed 

Scientific publications (26)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HABENSCHUS, MAISA DANIELA; NARDINI, VIVIANI; DIAS, LUIS GUSTAVO; ROCHA, BRUNO ALVES; BARBOSA, JR., FERNANDO; MORAES DE OLIVEIRA, ANDERSON RODRIGO. In vitro enantioselective study of the toxicokinetic effects of chiral fungicide tebuconazole in human liver microsomes. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 181, p. 96-105, OCT 15 2019. Web of Science Citations: 0.
ALVES, NELSON A.; DIAS, LUIS G.; FRIGORI, RAFAEL B. Synergistic long-range effects of mutations underlie aggregation propensities of amylin analogues. Journal of Molecular Modeling, v. 25, n. 9 SEP 2019. Web of Science Citations: 0.
PARK, PETER; FRANCO, LEANDRO R.; CHAIMOVICH, HERNAN; COUTINHO, KALINE; CUCCOVIA, IOLANDA M.; LIMA, FILIPE S. Binding and Flip as Initial Steps for BP-100 Antimicrobial Actions. SCIENTIFIC REPORTS, v. 9, JUN 13 2019. Web of Science Citations: 0.
FONSECA, FRANCIELE S.; CARRAO, DANIEL B.; DE ALBUQUERQUE, NAYARA C. P.; NARDINI, VIVIANI; DIAS, LUIS G.; DA SILVA, RODRIGO M.; LOPES, NORBERTO P.; DE OLIVEIRA, ANDERSON R. M. Myclobutanil enantioselective risk assessment in humans through in vitro CYP450 reactions: Metabolism and inhibition studies. Food and Chemical Toxicology, v. 128, p. 202-211, JUN 2019. Web of Science Citations: 2.
CAUZ, ANA C. G.; CARRETERO, GUSTAVO P. B.; SARAIVA, GREICE K. V.; PARK, PETER; MORTARA, LAURA; CUCCOVIA, IOLANDA M.; BROCCHI, MARCELO; GUEIROS-FILHO, FREDERICO J. Violacein Targets the Cytoplasmic Membrane of Bacteria. ACS INFECTIOUS DISEASES, v. 5, n. 4, p. 539-549, APR 2019. Web of Science Citations: 0.
SARAIVA, G. K. V.; DE SOUZA, V. V.; COUTINHO DE OLIVEIRA, L.; NORONHA, M. L. C.; MASINI, J. C.; CHAIMOVICH, H.; SALINAS, R. K.; FLORENZANO, F. H.; CUCCOVIA, I. M. Characterization of PMMA-b-PDMAEMA aggregates in aqueous solutions. COLLOID AND POLYMER SCIENCE, v. 297, n. 4, p. 557-569, APR 2019. Web of Science Citations: 0.
PEREIRA-LEITE, CATARINA; LOPES-DE-CAMPOS, DANIELA; FONTAINE, PHILIPPE; CUCCOVIA, IOLANDA M.; NUNES, CLAUDIA; REIS, SALETTE. Licofelone-DPPC Interactions: Putting Membrane Lipids on the Radar of Drug Development. Molecules, v. 24, n. 3 FEB 1 2019. Web of Science Citations: 0.
RAFAEL THEOTONIO DE CASTRO; MAITHE PINHEIRO DOS SANTOS; FÁBIO HERBST FLORENZANO. Urea-based polymethacrylamide purification. MATERIA-RIO DE JANEIRO, v. 24, n. 3, p. -, 2019. Web of Science Citations: 0.
MORAES, THAISA B. F.; SCHIMIDT, MARCOS F. R. A.; BACANI, REBECA; WEBER, GABRIEL; POLITI, MARIO J.; CASTANHEIRA, BRUNA; BROCHSZTAIN, SERGIO; SILVA, FRANCISCO DE A.; DEMETS, GREGOIRE J-F; TRIBONI, EDUARDO R. Polysilsesquioxane naphthalenediimide thermo and photochromic gels. Journal of Luminescence, v. 204, p. 685-691, DEC 2018. Web of Science Citations: 0.
RODRIGUES, BRUNO V. M.; CABRAL, TAYNA S.; SGOBBI, LIVIA F.; DELEZUK, JORGE A. M.; PESSOA, RODRIGO S.; TRIBONI, EDUARDO R.; DE MORAES, THAISA B. F.; LOBO, ANDERSON O. A simple and green method for the production of nanostructured materials from poly(vinyl alcohol)/graphene quantum dots. Materials Chemistry and Physics, v. 219, p. 242-250, NOV 1 2018. Web of Science Citations: 1.
SIANI, P.; KHANDELIA, H.; ORSI, M.; DIAS, L. G. Parameterization of a coarse-grained model of cholesterol with point-dipole electrostatics. Journal of Computer-Aided Molecular Design, v. 32, n. 11, p. 1259-1271, NOV 2018. Web of Science Citations: 1.
MORTARA, LAURA; LIMA, FILIPE DA SILVA; CUCCOVIA, IOLANDA MIDEA; NAZET, ANDREAS; HORINEK, DOMINIK; BUCHNER, RICHARD; CHAIMOVICH, HERNAN. Specific Ion Effects on Zwitterionic Micelles Are Independent of Interfacial Hydration Changes. Langmuir, v. 34, n. 37, p. 11049-11057, SEP 18 2018. Web of Science Citations: 0.
PEREIRA-LEITE, CATARINA; NUNES, CLAUDIA; BOZELLI, JR., JOSE C.; SCHREIER, SHIRLEY; KAMMA-LORGER, CHRISTINA S.; CUCCOVIA, IOLANDA M.; REIS, SALETTE. Can NO-indomethacin counteract the topical gastric toxicity induced by indomethacin interactions with phospholipid bilayers?. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 169, p. 375-383, SEP 1 2018. Web of Science Citations: 1.
CARRETERO, GUSTAVO P. B.; SARAIVA, V, GREICE K.; CAUZ, ANA C. G.; RODRIGUES, MAGALI A.; KIYOTA, SUMIKA; RISKE, KARIN A.; DOS SANTOS, ALCINDO A.; PINATTO-BOTELHO, MARCOS F.; BEMQUERER, MARCELO P.; GUEIROS-FILHO, FREDERICO J.; CHAIMOVICH, HERNAN; SCHREIER, SHIRLEY; CUCCOVIA, IOLANDA M. Synthesis, biophysical and functional studies of two BP100 analogues modified by a hydrophobic chain and a cyclic peptide. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1860, n. 8, p. 1502-1516, AUG 2018. Web of Science Citations: 5.
PEREIRA-LEITE, CATARINA; NUNES, CLAUDIA; GRAHL, DEBORA; BOZELLI, JR., JOSE C.; SCHREIER, SHIRLEY; KAMMA-LORGER, CHRISTINA S.; CUCCOVIA, IOLANDA M.; REIS, SALETTE. Acemetacin-phosphatidylcholine interactions are determined by the drug ionization state. Physical Chemistry Chemical Physics, v. 20, n. 21, p. 14398-14409, JUN 7 2018. Web of Science Citations: 1.
NARDINI, VIVIANI; DIAS, LUIS GUSTAVO; PALARETTI, VINICIUS; JOSE DA SILVA, GIL VALDO. Citronellal assumes a folded conformation in solution due to dispersion interactions: A joint NMR-DFT analysis. Journal of Molecular Structure, v. 1157, p. 401-407, APR 5 2018. Web of Science Citations: 2.
DA SILVA, FATIMA CHAGAS; PINHEIRO DA SILVA, MAURO FRANCISCO; BRIOTTO FILHO, DECIO; POLITI, MARIO JOSE; BACANI, REBECA; TRIBONI, EDUARDO REZENDE. Tuned charge-transfer between ceria and 1,4,5,8-naphthaldiimide as a function of pH. Journal of Luminescence, v. 194, p. 240-247, FEB 2018. Web of Science Citations: 0.
SEGAL, FELIPE MODOLO; CORREA, MICHELLE FIDELIS; BACANI, REBECA; CASTANHEIRA, BRUNA; POLITI, MARIO JOSE; BROCHSZTAIN, SERGIO; TRIBONI, EDUARDO REZENDE. A Novel Synthesis Route of Mesoporous gamma Alumina from Polyoxohydroxide Aluminum. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 21, n. 1 2018. Web of Science Citations: 0.
LIMA, FILIPE S.; ANDRADE, MARCOS F. C.; MORTARA, LAURA; DIAS, LUIS GUSTAVO; CUCCOVIA, IOLANDA M.; CHAIMOVICH, HERNAN. Ion dehydration controls adsorption at the micellar interface: hydrotropic ions. Physical Chemistry Chemical Physics, v. 19, n. 45, p. 30658-30666, DEC 7 2017. Web of Science Citations: 3.
CRUZ, MARCOS A. E.; DE SOUZA, RAFAEL MAGLIA; DIAS, LUIS GUSTAVO; RAMOS, ANA PAULA. Counterion-mediated Ca2+ accumulation on cationic Langmuir-Blodgett films as template for CaCO3 growth. Thin Solid Films, v. 638, p. 433-440, SEP 30 2017. Web of Science Citations: 3.
DE SOUZA, R. M.; SIANI, P.; SCHMIDT, T. F.; ITRI, R.; DIAS, L. G. Methylene Blue Location in (Hydroperoxized) Cardiolipin Monolayer: Implication in Membrane Photodegradation. Journal of Physical Chemistry B, v. 121, n. 36, p. 8512-8522, SEP 14 2017. Web of Science Citations: 1.
PEREIRA-LEITE, CATARINA; NUNES, CLAUDIA; JAMAL, SARAH K.; CUCCOVIA, IOLANDA M.; REIS, SALETTE. Nonsteroidal Anti-Inflammatory Therapy: A Journey Toward Safety. MEDICINAL RESEARCH REVIEWS, v. 37, n. 4, p. 802-859, JUL 2017. Web of Science Citations: 22.
CHAGAS, FERNANDA O.; DIAS, LUIS G.; PUPO, MONICA T. New perylenequinone derivatives from the endophytic fungus Alternaria tenuissima SS77. Tetrahedron Letters, v. 57, n. 29, p. 3185-3189, JUL 20 2016. Web of Science Citations: 4.
BARROSO DA SILVA, FERNANDO LUIS; PASQUALI, SAMUELA; DERREUMAUX, PHILIPPE; DIAS, LUIS GUSTAVO. Electrostatics analysis of the mutational and pH effects of the N-terminal domain self-association of the major ampullate spidroin. SOFT MATTER, v. 12, n. 25, p. 5600-5612, 2016. Web of Science Citations: 10.
CRUZ, GUSTAVO N.; LIMA, FILIPE S.; DIAS, LUIS G.; EL SEOUD, OMAR A.; HORINEK, DOMINIK; CHAIMOVICH, HERNAN; CUCCOVIA, IOLANDA M. Molecular Dynamics Simulations of the Initial-State Predict Product Distributions of Dediazoniation of Aryldiazonium in Binary Solvents. Journal of Organic Chemistry, v. 80, n. 17, p. 8637-8642, SEP 4 2015. Web of Science Citations: 2.
MANZINI, MARIANA C.; PEREZ, KATIA R.; RISKE, KARIN A.; BOZELLI, JR., JOSE C.; SANTOS, TALITA L.; DA SILVA, MARCIA A.; SARAIVA, GREICE K. V.; POLITI, MARIO J.; VALENTE, ANA P.; ALMEIDA, FABIO C. L.; CHAIMOVICH, HERNAN; RODRIGUES, MAGALI A.; BEMQUERER, MARCELO P.; SCHREIER, SHIRLEY; CUCCOVIA, IOLANDA M. Peptide:lipid ratio and membrane surface charge determine the mechanism of action of the antimicrobial peptide BP100. Conformational and functional studies. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1838, n. 7, p. 1985-1999, JUL 2014. Web of Science Citations: 43.

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