Development of microneedie array (microeletronic tongue) for quantification and discrimination of hormones

• Grant number: 13/50751-2
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2013
• End date: November 30, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Agreement: North Carolina State University
• Principal Investigator: Thiago Regis Longo Cesar da Paixão
• Grantee: Thiago Regis Longo Cesar da Paixão
• Principal researcher abroad: Roger Nagdish Narayan
• Institution abroad: North Carolina State University (NC State), United States
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 12/12106-5 - Development of intelligent devices (electronic noses and tongues) using electrochemical, colorimetric and mass measurements aiming to the discrimination of forensic and food samples, AP.R

Abstract

Cortisol is a glucocorticoid hormone that is associated with several important physiologic processes, including inflammation, blood pressure, glucose metabolism, and fat metabolism. In addition, it is associated with acute stress; for example, emotional stress leads to cortisol release, which in turn facilitates the funcfion of adrenaline and other catecholamines. Cortisol has been described as a potential index for stress, particularly for acute mental stressors. In this proposal, Dr. Paixão's group and Dr. Narayan's group will jointly develop a nanostructured molecularly imprinted polymer microneedle-based device for transdermal detection of cortisol, a glucocorticoid hormone. Molecularly imprinted polymers are materiais with nanoscale features that imitate antibodies and other natural structures. Additionally, the proposed sensors and tongues could be applied to other applications related to forensics and food safety. (AU)