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Development of microneedie array (microeletronic tongue) for quantification and discrimination of hormones

Abstract

Cortisol is a glucocorticoid hormone that is associated with several important physiologic processes, including inflammation, blood pressure, glucose metabolism, and fat metabolism. In addition, it is associated with acute stress; for example, emotional stress leads to cortisol release, which in turn facilitates the funcfion of adrenaline and other catecholamines. Cortisol has been described as a potential index for stress, particularly for acute mental stressors. In this proposal, Dr. Paixão's group and Dr. Narayan's group will jointly develop a nanostructured molecularly imprinted polymer microneedle-based device for transdermal detection of cortisol, a glucocorticoid hormone. Molecularly imprinted polymers are materiais with nanoscale features that imitate antibodies and other natural structures. Additionally, the proposed sensors and tongues could be applied to other applications related to forensics and food safety. (AU)