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Connexin and pannexin channels as drug targets and biomarkers in acute and chronic liver disease

Grant number: 13/50420-6
Support type:Research Projects - SPEC Program
Duration: April 01, 2014 - March 31, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Mathieu Frederick Alexander Vinken
Grantee:Mathieu Frederick Alexander Vinken
Visiting researcher institution: Vrije Universiteit Brussel (VUB), Belgium
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Bruno Cogliati ; Maria Lucia Zaidan Dagli
Associated scholarship(s):16/16182-9 - Characterization of connexin 32 and connexin 43 expression in non-alcoholic fatty liver disease in mice, BP.IC
16/03579-8 - Connexin and pannexin channels as drug targets and biomarkers in acute and chronic liver diseases, BP.IC
14/23887-3 - Connexin and pannexin channels as drug targets and biomarkers in acute and chronic liver disease, BP.PD
14/23890-4 - Connexin and pannexin channels as drug targets and biomarkers in acute and chronic liver diseases, BP.PD

Abstract

Although being in its infancy and surrounded by controversy, it is now believed that connexin (Cx) hemichannels and pannexin (Panx) channels act as pathological pores that connect the cytoplasm of cells with the extracellular environment and which facilit (AU)

Scientific publications (24)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
YANGUAS, SARA CRESPO; DA SILVA, TEREZA C.; PEREIRA, ISABEL V. A.; MAES, MICHAEL; WILLEBRORDS, JOOST; SHESTOPALOV, VALERY I.; GOES, BRUNA M.; NOGUEIRA, MARINA SAYURI; DE CASTRO, INAR ALVES; ROMUALDO, GUILHERME R.; BARBISAN, LUIS F.; GIJBELS, EVA; VINKEN, MATHIEU; COGLIATI, BRUNO. Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model. ARCHIVES OF TOXICOLOGY, v. 92, n. 8, p. 2607-2627, AUG 2018. Web of Science Citations: 2.
WILLEBRORDS, JOOST; MAES, MICHAEL; ALVES PEREIRA, ISABEL VELOSO; DA SILVA, TEREZA CRISTINA; GOVONI, VERONICA MOLLICA; LOPES, VALERIA VERAS; YANGUAS, SARA CRESPO; SHESTOPALOV, VALERY I.; NOGUEIRA, MARINA SAYURI; DE CASTRO, INAR ALVES; FARHOOD, ANWAR; MANNAERTS, INGE; VAN GRUNSVEN, LEO; AKAKPO, JEPHTE; LEBOFSKY, MARGITTA; JAESCHKE, HARTMUT; COGLIATI, BRUNO; VINKEN, MATHIEU. Protective effect of genetic deletion of pannexinl in experimental mouse models of acute and chronic liver disease. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 1864, n. 3, p. 819-830, MAR 2018. Web of Science Citations: 4.
YANGUAS, SARA CRESPO; DA SILVA, TEREZA C.; PEREIRA, ISABEL V. A.; WILLEBRORDS, JOOST; MAES, MICHAEL; NOGUEIRA, MARINA SAYURI; DE CASTRO, INAR ALVES; LECLERCQ, ISABELLE; ROMUALDO, GUILHERME R.; BARBISAN, LUIS F.; LEYBAERT, LUC; COGLIATI, BRUNO; VINKEN, MATHIEU. TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 3 MAR 2018. Web of Science Citations: 2.
MAES, MICHAEL; YANGUAS, SARA CRESPO; WILLEBRORDS, JOOST; WEEMHOFF, JAMES L.; DA SILVA, TEREZA CRISTINA; DECROCK, ELKE; LEBOFSKY, MARGITTA; ALVES PEREIRA, ISABEL VELOSO; LEYBAERT, LUC; FARHOOD, ANWAR; JAESCHKE, HARTMUT; COGLIATI, BRUNO; VINKEN, MATHIEU. Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice. Toxicology Letters, v. 278, p. 30-37, AUG 15 2017. Web of Science Citations: 11.
WILLEBRORDS, JOOST; COGLIATI, BRUNO; ALVES PEREIRA, ISABEL VELOSO; DA SILVA, TEREZA CRISTINA; YANGUAS, SARA CRESPO; MAES, MICHAEL; GOVONI, VERONICA MOLLICA; LIMA, ANDRESSA; FELISBINO, DANIELE APARECIDA; DECROCK, ELKE; NOGUEIRA, MARINA SAYURI; DE CASTRO, INAR ALVES; LECLERCQ, ISABELLE; LEYBAERT, LUC; RODRIGUES, ROBIM MARCELINO; VINKEN, MATHIEU. Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice. SCIENTIFIC REPORTS, v. 7, AUG 15 2017. Web of Science Citations: 10.
MAES, MICHAEL; MCGILL, MITCHELL R.; DA SILVA, TEREZA CRISTINA; ABELS, CHLOE; LEBOFSKY, MARGITTA; WEEMHOFF, JAMES L.; TIBURCIO, TAYNA; ALVES PEREIRA, ISABEL VELOSO; WILLEBRORDS, JOOST; YANGUAS, SARA CRESPO; FARHOOD, ANWAR; BESCHIN, ALAIN; VAN GINDERACHTER, JO A.; PENUELA, SILVIA; JAESCHKE, HARTMUT; COGLIATI, BRUNO; VINKEN, MATHIEU. Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity. ARCHIVES OF TOXICOLOGY, v. 91, n. 5, p. 2245-2261, MAY 2017. Web of Science Citations: 7.
TIBURCIO, TAYNA CRISTINA; WILLEBRORDS, JOOST; DA SILVA, TEREZA CRISTINA; ALVES PEREIRA, ISABEL VELOSO; NOGUEIRA, MARINA SAYURI; YANGUAS, SARA CRESPO; MAES, MICHAEL; SILVA, ELISANGELA DOS ANJOS; ZAIDAN DAGLI, MARIA LUCIA; DE CASTRO, INAR ALVES; OLIVEIRA, CLAUDIA PINTO; VINKEN, MATHIEU; COGLIATI, BRUNO. Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non-alcoholic steatohepatitis. Clinical and Experimental Pharmacology and Physiology, v. 44, n. 2, p. 197-206, FEB 2017. Web of Science Citations: 5.
YANGUAS, SARA CRESPO; WILLEBRORDS, JOOST; JOHNSTONE, SCOTT R.; MAES, MICHAEL; DECROCK, ELKE; DE BOCK, MARIJKE; LEYBAERT, LUC; COGLIATI, BRUNO; VINKEN, MATHIEU. Pannexin1 as mediator of inflammation and cell death. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1864, n. 1, p. 51-61, JAN 2017. Web of Science Citations: 22.
WILLEBRORDS, JOOST; YANGUAS, SARA CRESPO; MAES, MICHAEL; DECROCK, ELKE; WANG, NAN; LEYBAERT, LUC; KWAK, BRENDA R.; GREEN, COLIN R.; COGLIATI, BRUNO; VINKEN, MATHIEU. Connexins and their channels in inflammation. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, v. 51, n. 6, p. 413-439, NOV-DEC 2016. Web of Science Citations: 26.
COGLIATI, BRUNO; YANGUAS, SARA CRESPO; DA SILVA, TEREZA CRISTINA; ARRAIS ALOIA, THIAGO PINHEIRO; NOGUEIRA, MARINA SAYURI; REAL-LIMA, MIRELA ALINE; CHAIBLE, LUCAS MARTINS; SANCHES, DANIEL SOARES; WILLEBRORDS, JOOST; MAES, MICHAEL; ALVES PEREIRA, ISABEL VELOSO; DE CASTRO, INAR ALVES; VINKEN, MATHIEU; ZAIDAN DAGLI, MARIA LUCIA. Connexin32 deficiency exacerbates carbon tetrachloride-induced hepatocellular injury and liver fibrosis in mice. TOXICOLOGY MECHANISMS AND METHODS, v. 26, n. 5, p. 362-370, JUN 2016. Web of Science Citations: 4.
COGLIATI, BRUNO; MENNECIER, GREGORY; WILLEBRORDS, JOOST; DA SILVA, TEREZA CRISTINA; MAES, MICHAEL; ALVES PEREIRA, ISABEL VELOSO; YANGUAS, SARA CRESPO; HERNANDEZ-BLAZQUEZ, FRANCISCO JAVIER; ZAIDAN DAGLI, MARIA LUCIA; VINKEN, MATHIEU. Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases. Journal of Membrane Biology, v. 249, n. 3, p. 199-213, JUN 2016. Web of Science Citations: 6.
MAES, MICHAEL; MCGILL, MITCHELL R.; DA SILVA, TEREZA CRISTINA; ABELS, CHLOE; LEBOFSKY, MARGITTA; MONTEIRO DE ARAUJO, CINTIA MARIA; TIBURCIO, TAYNA; ALVES PEREIRA, ISABEL VELOSO; WILLEBRORDS, JOOST; YANGUAS, SARA CRESPO; FARHOOD, ANWAR; BESCHIN, ALAIN; VAN GINDERACHTER, JO A.; ZAIDAN DAGLI, MARIA LUCIA; JAESCHKE, HARTMUT; COGLIATI, BRUNO; VINKEN, MATHIEU. Involvement of connexin43 in acetaminophen-induced liver injury. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 1862, n. 6, p. 1111-1121, JUN 2016. Web of Science Citations: 12.
YANGUAS, SARA CRESPO; COGLIATI, BRUNO; WILLEBRORDS, JOOST; MAES, MICHAEL; COLLE, ISABELLE; VAN DEN BOSSCHE, BERT; MARQUES SOUZA DE OLIVEIRA, CLAUDIA PINTO; ANDRAUS, WELLINGTON; ALVES, VENANCIO AVANCINI; LECLERCQ, ISABELLE; VINKEN, MATHIEU. Experimental models of liver fibrosis. ARCHIVES OF TOXICOLOGY, v. 90, n. 5, p. 1025-1048, MAY 2016. Web of Science Citations: 35.
MAES, MICHAEL; MCGILL, MITCHELL R.; DA SILVA, TEREZA CRISTINA; LEBOFSKY, MARGITTA; MONTEIRO DE ARAUJO, CINTIA MARIA; TIBURCIO, TAYNA; ALVES PEREIRA, ISABEL VELOSO; WILLEBRORDS, JOOST; YANGUAS, SARA CRESPO; FARHOOD, ANWAR; ZAIDAN DAGLI, MARIA LUCIA; JAESCHKE, HARTMUT; COGLIATI, BRUNO; VINKEN, MATHIEU. Connexin32: a mediator of acetaminophen- induced liver injury?. TOXICOLOGY MECHANISMS AND METHODS, v. 26, n. 2, p. 88-96, FEB 12 2016. Web of Science Citations: 5.
VINKEN, MATHIEU. Regulation of connexin signaling by the epigenetic machinery. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, v. 1859, n. 2, p. 262-268, FEB 2016. Web of Science Citations: 12.
YANGUAS, SARA CRESPO; WILLEBRORDS, JOOST; MAES, MICHAEL; DA SILVA, TEREZA CRISTINA; ALVES PEREIRA, ISABEL VELOSO; COGLIATI, BRUNO; ZAIDAN DAGLI, MARIA LUCIA; VINKEN, MATHIEU. CONNEXINS AND PANNEXINS IN LIVER DAMAGE. EXCLI JOURNAL, v. 15, p. 177-186, 2016. Web of Science Citations: 10.
MAES, MICHAEL; YANGUAS, SARA CRESPO; WILLEBRORDS, JOOST; VINKEN, MATHIEU. Models and methods for in vitro testing of hepatic gap junctional communication. TOXICOLOGY IN VITRO, v. 30, n. 1, B, p. 569-577, DEC 25 2015. Web of Science Citations: 2.
MAES, MICHAEL; YANGUAS, SARA CRESPO; WILLEBRORDS, JOOST; COGLIATI, BRUNO; VINKEN, MATHIEU. Connexin and pannexin signaling in gastrointestinal and liver disease. TRANSLATIONAL RESEARCH, v. 166, n. 4, p. 332-343, OCT 2015. Web of Science Citations: 21.
MAES, MICHAEL; COGLIATI, BRUNO; YANGUAS, SARA CRESPO; WILLEBRORDS, JOOST; VINKEN, MATHIEU. Roles of connexins and pannexins in digestive homeostasis. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 72, n. 15, p. 2809-2821, AUG 2015. Web of Science Citations: 13.
VINKEN, MATHIEU. Introduction: connexins, pannexins and their channels as gatekeepers of organ physiology. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 72, n. 15, p. 2775-2778, AUG 2015. Web of Science Citations: 13.
COGLIATI, BRUNO; VINKEN, MATHIEU; SILVA, TEREZA C.; ARAUJO, CINTIA M. M.; ALOIA, THIAGO P. A.; CHAIBLE, LUCAS M.; MORI, CLAUDIA M. C.; DAGLI, MARIA L. Z. Connexin 43 deficiency accelerates skin wound healing and extracellular matrix remodeling in mice. JOURNAL OF DERMATOLOGICAL SCIENCE, v. 79, n. 1, p. 50-56, JUL 2015. Web of Science Citations: 19.
WILLEBRORDS, JOOST; ALVES PEREIRA, ISABEL VELOSO; MAES, MICHAEL; YANGUAS, SARA CRESPO; COLLE, ISABELLE; VAN DEN BOSSCHE, BERT; DA SILVA, TEREZA CRISTINA; MARQUES SOUZA DE OLIVEIRA, CLAUDIA PINTO; ANDRAUS, WELLINGTON; ALVES, VENANCIO AVANCINI; COGLIATI, BRUNO; VINKEN, MATHIEU. Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research. PROGRESS IN LIPID RESEARCH, v. 59, p. 106-125, JUL 2015. Web of Science Citations: 51.
WILLEBRORDS, JOOST; YANGUASA, SARA CRESPO; MAES, MICHAEL; DECROCK, ELKE; WANG, NAN; LEYBAERT, LUC; DA SILVA, TEREZA CRISTINA; ALVES PEREIRA, ISABEL VELOSO; JAESCHKE, HARTMUT; COGLIATI, BRUNO; VINKEN, MATHIEU. Structure, Regulation and Function of Gap Junctions in Liver. CELL COMMUNICATION AND ADHESION, v. 22, n. 2-6, p. 29-37, 2015. Web of Science Citations: 3.
MAES, MICHAEL; DECROCK, ELKE; COGLIATI, BRUNO; OLIVEIRA, ANDRE G.; MARQUES, PEDRO E.; DAGLI, MARIA L. Z.; MENEZES, GUSTAVO B.; MENNECIER, GREGORY; LEYBAERT, LUC; VANHAECKE, TAMARA; ROGIERS, VERA; VINKEN, MATHIEU. Connexin and pannexin (hemi) channels in the liver. FRONTIERS IN PHYSIOLOGY, v. 4, JAN 10 2014. Web of Science Citations: 28.

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