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Comparison of the clinical efficacy of 4% articaine with 1:100.000 or 1:200.000 epinephrine for the control of pain and bleeding in mucogingival surgeries

Grant number: 12/21846-2
Support Opportunities:Regular Research Grants
Duration: December 01, 2013 - April 30, 2015
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Bella Luna Colombini Ishikiriama
Grantee:Bella Luna Colombini Ishikiriama
Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil
Associated researchers:Carlos Ferreira dos Santos ; Patricia Pinto Saraiva


The control of postoperative pain in patients undergoing oral and maxillofacial surgery is often performed through the administration of local anesthetics and oral analgesics. After periodontal surgery, the maximum intensity of pain occurs in the first hours after the end of the surgery, shortly after the completion of the anesthetic effect. Theoretically it may be possible to increase the control of postoperative pain by lengthening the period of analgesia using a long lasting anesthetic agent. Moreover, it is possible to achieve a better control of pain and surgical bleeding through the association of vasoconstrictor agents in the anesthetic solutions, such as adrenaline, and higher concentrations may generate less bleeding. For this reason, this research aims to evaluate the clinical efficacy of articaine, a long-lasting anesthetic agent containing epinephrine in concentrations of 1:100,000 and 1:200,000, in pain and bleeding control in the surgical model of bilateral free gingival grafts. The study involves 30 patients that require bilateral free gingival grafts in the region of premolars. The surgical procedures will be conducted in a crossover model, from which data related to the anesthetic and the vasoconstrictor effects will be collected. Appropriate statistical tests will be applied to provide the basis for an evaluation of the clinical efficacy of both anesthetic agents for pain control and bleeding when performing periodontal mucogingival surgeries. (AU)

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