Abstract
Fleshy fruits are considered as rich in soluble fibers, and its consumption could reduce chronic non-communicable diseases (NCDs) frequency, including some sorts of cancer. Pectin, the main polysaccharides of fleshy fruit soluble fibers, could inhibit the pro-metastatic protein galectin-3 by selective binding of pectin-derived galactans in vivo and in vitro, thus reducing cancer cells growth. Pectin could also be fermented by human intestinal microbiota, inducing growth of symbiotic bacteria and producing short chain fatty acids (SCFA), which could in turn prevent colon cancer. Because of papaya is considered a pectin-rich fruit with great amounts of pectin-derived galactans, the project has the main objective of establishing a correlation between chemical structures of papaya pectins and its probable human consumption benefits. To achieve this goal, experiments comprising cultured cells treated with papaya pectins should be performed, as well as in vitro colonic fermentation and its metagenome. Controlled enzymatic treatments of papaya pectins ("fiber food engineering") could complement a possible improvement on health parameters. The results arose from this study would open new perspectives on the development of functional foods derived from pectin-rich fruits. (AU)
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PROCESSO PARA EXTRAÇÃO E ISOLAMENTO DE FIBRAS ALIMENTARES DE MAMÕES RICAS EM PECTINAS E USO DAS MESMAS BR 10 2018 074786 0 - Universidade de São Paulo (USP). . João Paulo Fabi; Samira Bernardino Ramos Do Prado; Tânia Misuzu Shiga - January 2018, 01