Aging is associated with development of metabolic disorders and neurodegenerative diseases triggered by the reduction of antioxidant defenses, with alteration in apoptotic and autophagy processes. Studies reported autophagy as a strategy for neuroprotection in aging and neurodegenerative diseases, although little is known about its role in peripheral tissues. The scientific challenges of this project will determine the mode of action of lithium on the striatum tissue and liver in young and aged animals. Female Wistar rats will be divided in two groups: young (4-6 months) and aged (22-26 months). Young animals will be sorted in two subgroups differing in liquid solution: C group, control that will receive distilled water ; L group, receiving solution of lithium in neuroprotective concentration. The aged group will be sorted in two subgroups: S group, which receives distilled water; SL group, receiving solution of lithium in neuroprotective concentration. After 30 days of experiment will be analyzed the behavior test, autophagy, oxidative stress in liver and striatum, beyond lipid profile in serum of young and aged rats. It is expected an antioxidant or a cytoprotective activity of lithium, with a increase of autophagy. We can also analyze the effect of lithium in the prevention of oxidative stress and mitochondrial damage associated with aging. (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
URESHINO, RODRIGO PORTES;
ERUSTES, ADOLFO GARCIA;
BASSANI, TAYSA BERVIAN;
GUARACHE, GABRIEL CICOLIN;
NASCIMENTO, ANA CAROLINA;
COSTA, ANGELICA JARDIM;
SMAILI, SORAYA SOUBHI;
DA SILVA PEREIRA, GUSTAVO JOSE.
The Interplay between Ca2+ Signaling Pathways and Neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,
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