Nanostructured organic-inorganic hybrids for controlled lignans release with pharmacological potential

• Grant number: 13/20455-2
• Support Opportunities: Research Grants - Young Investigators Grants
• Duration: April 01, 2014 - June 30, 2018
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Eduardo Ferreira Molina
• Grantee: Eduardo Ferreira Molina
• Host Institution: Reitoria. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated researchers: Márcio Luís Andrade e Silva ; Wilson Roberto Cunha
• Associated grant(s): 21/06552-1 - TASTYGEL: sustainable release of nutrients by smart micro- and nanogels based on polyetheramines-bisepoxide for Agriculture purposes, AP.JP2
• Associated scholarship(s): 15/02802-2 - Hybrid materials based on silica and polyetheramines as a dual-drug-delivery vehicle, BP.MS; 14/18876-2 - Evaluation of organic-inorganic hybrid matrices as film formers for lignans controlled release through transdermal route, BP.IC

Abstract

This research project will be developed by a team with a responsible researcher and two research associates, as well as its undergraduate students and graduate students. The objective of this proposal is to develop new materials for pharmaceutical formulation of transdermal (patches) and implantable systems for controlled drug delivery-based nanostructured materials, such as hybrid organic-inorganic type siloxane-polyether to release the active substances (lignans) in a controlled manner and having optical, mechanical and structural higher than those in the market. The structural features are correlated with the release profiles of the active agents to optimize the final characteristics of the devices. These matrices are prepared by sol-gel using polyethers of different molar mass. The hydrophobic / hydrophilic organic phase present in the matrix will determine control of swelling / diffusion in the release of incorporated substances. These materials are stable and non-toxic. The possibility of modulating the profile and release kinetics from these hybrid arrays, motivates us understanding of both the conceptual point of view as the possibility of preparation of multifunctional materials. Moreover, they have unique properties such as high mechanical strength, transparency, flexibility, and are insoluble in water being convenient for applications in various scientific and technological areas, including human health. It is hoped that this project allow the nucleation of a new research group at the Universidade de Franca, in the area of controlled drug release. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, LILIAN K.; MOURA, ANDRE L. A.; BARBOSA, VALDIR; PARREIRA, RENATO L. T.; BANEGAS, RODRIGO S.; CARAMORI, GIOVANNI F.; CIUFFI, KATIA J.; MOLINA, EDUARDO F.. Removal of the emerging contaminant bisphenol A by an ureasil-PEO hybrid membrane: experimental study and molecular dynamic simulation. Environmental Science and Pollution Research, v. 24, n. 22, p. 18421-18433, AUG 2017. (16/01501-1, 13/20455-2)

CARAVIERI, BEATRIZ B.; DE JESUS, NATANA A. M.; DE OLIVEIRA, LILIAN K.; ARAUJO, MARINA D.; ANDRADE, GABRIELE P.; MOLINA, EDUARDO F.. Ureasil Organic-Inorganic Hybrid as a Potential Carrier for Combined Delivery of Anti-Inflammatory and Anticancer Drugs. ACS APPLIED BIO MATERIALS, v. 2, n. 5, p. 9-pg., 2019-05-20. (15/02802-2, 13/20455-2)

BOCALON, LUZIO G.; TOZATTI, MARCOS G.; JANUARIO, ANA H.; PAULETTI, PATRICIA M.; SILVA, MARCIO L. A.; ROCHA, LUCAS A.; MOLINA, EDUARDO F.; SANTOS, MARIO F. C.; CUNHA, WILSON R.. Incorporation of Betulinic Acid into Silica-Based Nanoparticles for Controlled Phytochemical Release. Analytical Letters, v. N/A, p. 15-pg., 2022-09-03. (16/22228-1, 13/20455-2)

PERARO, GUSTAVO R.; DONZELLI, EDUARDO H.; OLIVEIRA, POLLYANNA F.; TAVARES, DENISE CRISPIM; MARTINS, CARLOS H. GOMES; MOLINA, EDUARDO F.; DE FARIA, EMERSON H.. Aminofunctionalized LAPONITE (R) as a versatile hybrid material for chlorhexidine digluconate incorporation: Cytotoxicity and antimicrobial activities. APPLIED CLAY SCIENCE, v. 195, SEP 15 2020. (13/19523-3, 13/20455-2, 17/15482-1)

DE SOUSA, EDUARDO P.; DE ARAUJO, DENIS T.; PEIXOTO, VINILSON G.; FERREIRA, BRENO F.; DE FARIA, EMERSON H.; MOLINA, EDUARDO F.. Effect of sodium bentonite content on structural-properties of ureasil poly (ethylene oxide)-PEO hybrid: A perspective for water treatment. APPLIED CLAY SCIENCE, v. 191, JUN 15 2020. (11/03335-8, 17/15482-1, 13/20455-2, 12/11673-3)

JULIA GABRIELA MATOS VARGAS; VINICIUS BUENO DA SILVA; LÍLIAN KARLA DE OLIVEIRA; EDUARDO FERREIRA MOLINA. MICROPLÁSTICOS: USO NA INDÚSTRIA COSMÉTICA E IMPACTOS NO AMBIENTE AQUÁTICO. Química Nova, v. 45, n. 6, p. 705-711, 2022-08-29.

MOURA, ANDRE L. A.; DE OLIVEIRA, LILIAN K.; CIUFFI, KATIA J.; MOLINA, EDUARDO F.. Influence of the hydrophilic/hydrophobic nature of polyetheramines on the interaction between amine-alcohol-silicate hybrids and anionic dyes for effective water cleaning. JOURNAL OF MATERIALS CHEMISTRY A, v. 3, n. 31, p. 16020-16032, 2015. (13/20455-2)

BONATTINI, VINICIUS H.; PAULA, LUCAS A. L.; JESUS, NATANA A. M.; CRISPIM, DENISE; NICOLELLA, HELOIZA D.; MAGALHAES, LIZANDRA GUIDI; MOLINA, EDUARDO F.. One-step formation of polyurea gel as a multifunctional approach for biological and environmental applications. Polymer International, v. 69, n. 5, FEB 2020. (13/20455-2, 16/24456-1, 16/16804-0)

DE JESUS, NATANA A. M.; DE OLIVEIRA, ANNA H. P.; TAVARES, DENISE C.; FURTADO, RICARDO A.; DE SILVA, MARCIO L. A.; CUNHA, WILSON R.; MOLINA, EDUARDO F.. Biofilm formed from a tri-ureasil organic-inorganic hybrid gel for use as a cubebin release system. Journal of Sol-Gel Science and Technology, v. 88, n. 1, p. 192-201, OCT 2018. (13/20455-2, 14/18876-2)