Preeclampsia: future risk of chronic kidney disease and cardiovascular injury

• Grant number: 14/00213-7
• Support type: Regular Research Grants
• Duration: July 01, 2014 - December 31, 2016
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal researcher: Nelson Sass
• Grantee: Nelson Sass
• Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Preeclampsia is an important cause of glomerulonephritis in the world and it seems to be associated to future risk of nephropathy and cardiovascular disease. Several studies indicate that preeclampsia is an independent risk factor for long-term complications such as chronic hypertension, stroke, metabolic syndrome and glomerulonephritis. Investigate the history of preeclampsia is important to follow-up, early diagnosis and treatment of cardiovascular or renal disorders and should be part of the clinical practice.This project is a continuation of the same research group previously financed by Fapesp which evaluated the podocyturia in preeclampsia. The objective is to investigate future risk of cardiovascular and chronic kidney disease in women with history of preeclampsia by clinical, laboratory and epidemiologic criteria. The patients will be called, examined and submitted to bioimpedance test, dosage of albuminuria, albumin/creatinine ratio, urinary protein/creatinine, urinary retinol transporter protein, podocyturia, serum creatinine, urea , insulin, activated protein C, uric acid, triglycerides, cholesterol, cystatin C, complete blood count, homocysteine, glucose, vitamin D, vascular endothelial growth factor and soluble receptor for vascular endothelial growth factor. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SATO TEBET, JUSSARA LEIKO; KIRSZTAJN, GIANNA MASTROIANNI; FACCA, THAIS ALQUEZAR; NISHIDA, SONIA K.; PEREIRA, AMELIA RODRIGUES; MOREIRA, SILVIA REGINA; PESTANA MEDINA, JOSE OSMAR; SASS, NELSON. Pregnancy in renal transplant patients: Renal function markers and maternal-fetal outcomes. PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, v. 15, p. 108-113, JAN 2019. Web of Science Citations: 1.

FACCA, THAIS ALQUEZAR; MASTROIANNI-KIRSZTAJN, GIANNA; PEREIRA SABINO, AMELIA RODRIGUES; PASSOS, MICHELLE TIVERON; DOS SANTOS, LARISSA FATIMA; BROSCO FAMA, EDUARDO AUGUSTO; NISHIDA, SONIA KIYOMI; SASS, NELSON. Pregnancy as an early stress test for cardiovascular and kidney disease diagnosis. PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, v. 12, p. 169-173, APR 2018. Web of Science Citations: 5.

SABINO, ANNIBAL TAGLIAFERRI; DE SOUZA, EDUARDO; GOULART, ANA LUCIA; DE LIMA, ADRIANA MARTINS; SASS, NELSON. High Blood Pressure during Pregnancy is not a Protective Factor for Preterm Infants with Very Low Birth Weight. A Case-Control Study. Revista Brasileira de Ginecologia e Obstetrícia, v. 39, n. 4, p. 155-161, APR 2017. Web of Science Citations: 1.

GUILHERME SANTOS DA SILVA JUNIOR; SILVIA REGINA MOREIRA; SONIA K. NISHIDA; NELSON SASS; GIANNA MASTROIANNI KIRSZTAJN. Avaliação de alterações urinárias e função renal em gestantes com hipertensão arterial crônica. J. Bras. Nefrol., v. 38, n. 2, p. 191-202, Jun. 2016.

CRISTINA CANDIDO; MARINA PONTELLO CRISTELLI; ANA RAQUEL FERNANDES; ANDRE CAIRES ALVINO DE LIMA; LAILA ALMEIDA VIANA; JUSSARA L SATO; NELSON SASS; HELIO TEDESCO-SILVA; JOSE OSMAR MEDINA-PESTANA. Pregnancy after kidney transplantation: high rates of maternal complications. J. Bras. Nefrol., v. 38, n. 4, p. 421-426, Dez. 2016.

FERNANDA BADIANI ROBERTO; THAÍS ALQUEZAR FACCA; JUSSARA LEIKO SATO; AMÉLIA RODRIGUES PEREIRA SABINO; SONIA KIYOMI NISHIDA; GIANNA MASTROIANNI-KIRSZTAJN; NELSON SASS. Podocitúria em gestantes hipertensas crônicas pode predizer dano renal?. Revista Brasileira de Ginecologia e Obstetrícia, v. 37, n. 4, p. -, Abr. 2015.