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Cost-effectiveness of implementation of bundles to prevent bloodstream infection in intensive care units in the São Paulo State


Blood Stream Infections (BSI) are the most severe Healthcare-Associated Infections (HAI) that occurs at the Intensive Care Units (UCI), therefore it is essential giving priority to the measures aimed at reducing them. Up to now, there is no study evaluating the economic impact at government level on strategies to prevent BSI. The objective of this study is to develop a cost-effectiveness analysis from the social perspective and at level of HAI State Coordination on the implementation of bundles to prevent BSI addressed to a group of hospitals in the São Paulo State. This is a prospective quasi-experimental study of intervention to prevent BSI in ICU. The subjects of the study are the healthcare settings in the São Paulo State having ICU which will be recruited by means of a formal invitation addressed to those with BSI rate higher than 7.4 per 1.000 CVC-days in 2012. The cost-effectiveness unit (outcome) will be defined as the reduction of number of BSI per 1.000 CVC-days. The intervention to be applied will be the implementation of a bundle of measures to prevent BSI in ICU. Costs allocation will be gathered from the State level (as by the preventive actions at level of HAI State Coordination); and also from local level (ICU) which will be estimated from a representative sample of the participant health settings. Components of costs will include the logistic and technical structure for implementation of the bundled BSI prevention in ICU of the hospitals in the São Paulo State. (AU)

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