Abstract
Duchenne muscle dystrophy (DMD) is a progressive degenerative disease that affects skeletal and cardiac muscles, leading to death by the age of 25 due to cardiorespiratory failure. Although there is no cure for this disease, recent gene and drug therapies are being able to slow down the progression of the disease, improving life quality and duration. The need for new biomarkers to better follow the progression of the disease and to better evaluate the effects of these new therapies is one of the main points of investigation worldwide in DMD research. We previously demonstrated positive effects of omega-3 therapy in the mdx mice model of DMD, during the early stages of the disease. These promising results motivated us to go further on omega-3 mechanisms and effects. In the present study, by using modern techniques such as metabolomics, we will search for new potential biomarkers of dystrophy in omega-3 treated-mdx mice. We aim to offer data that can support omega-3 therapy in DMD clinical trials. (AU)
Scientific publications
(10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHAGAS BARBIN, ISABEL CRISTINA;
PEREIRA, JULIANO ALVES;
ROVERE, MATHEUS BERSAN;
MOREIRA, DRIELEN DE OLIVEIRA;
MARQUES, MARIA JULIA;
SANTO NETO, HUMBERTO.
Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy.
Journal of Anatomy,
v. 228,
n. 5,
p. 784-791,
MAY 2016.
Web of Science Citations: 10.
MARANHAO, JULIANA BARROS;
MOREIRA, DRIELEN DE OLIVEIRA;
MAURICIO, ADRIANA FOGAGNOLO;
DE CARVALHO, SAMARA CAMACARI;
FERRETTI, RENATO;
PEREIRA, JULIANO ALVES;
SANTO NETO, HUMBERTO;
MARQUES, MARIA JULIA.
Changes in calsequestrin, TNF-alpha, TGF-beta and MyoD levels during the progression of skeletal muscle dystrophy in mdx mice: a comparative analysis of the quadriceps, diaphragm and intrinsic laryngeal muscles.
International Journal of Experimental Pathology,
v. 96,
n. 5,
p. 285-293,
OCT 2015.
Web of Science Citations: 7.