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Development of novel materials and devices for miniaturized sample preparation techniques in the area of food safety

Grant number: 14/07347-9
Support type:Regular Research Grants
Duration: August 01, 2014 - January 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Fernando Mauro Lanças
Grantee:Fernando Mauro Lanças
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Assoc. researchers:Alvaro José dos Santos Neto

Abstract

The main goal of the present proposal is de development of novel materials to be utilized in sample preparation micro techniques. After optimization and validation, following international protocols, the proposed approach will be utilized in the analysis of samples of remarkable relevance in the food safety area.Three different types of materials will be investigated: (1) Molecularly Imprinted Polymers - MIPs, to be employed for the analysis of triazines and phenylureas in corn samples using different extraction techniques and formats such as "in-tube"-SPME, SBSE e MEPS; (2) Grafeno as sorbent material for MEPS ("Micro Extraction in Packed Syringe") - whose extraction efficiency will be compared with that obtained using commercialy available sorbents for the determination of pesticides in sugar-cane products; silica modified with ionic liquids (ILs) for the determinantion of sulfonamides in bovine milk, using miniaturized and hyphenated analytical separation systems such as on-line-SPE and "in tube"-SPME.In each individual case, after a selective extraction the analytes will be separated, identified and quantified through chromatographic techniques coupled with tandem mass spectrometry (MS/MS), already existent in the proponent laboratory.It is our hope that with the development of these novel sorbents (MIPs, graphene and ILs) and its use in different formats such as on-line SPE, in-tube SPME, SBSE e MEPS, more selectivity will be introduced in the sample preparation step, a critical step during the determination of residue and contaminants relevant to the food safety research area. (AU)

Scientific publications (29)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MACIEL, EDVALDO VASCONCELOS SOARES; MEJIA-CARMONA, KAREN; JORDAN-SINISTERRA, MARCELA; DA SILVA, LUIS FELIPE; VARGAS MEDINA, DEYBER ARLEY; LANCAS, FERNANDO MAURO. The Current Role of Graphene-Based Nanomaterials in the Sample Preparation Arena. FRONTIERS IN CHEMISTRY, v. 8, AUG 11 2020. Web of Science Citations: 0.
VARGAS MEDINA, DEYBER ARLEY; SOARES MACIEL, EDVALDO VASCONCELOS; DE TOFFOLI, ANA LUCIA; LANCAS, FERNANDO MAURO. Miniaturization of liquid chromatography coupled to mass spectrometry. 2. Achievements on modern instrumentation for miniaturized liquid chromatography coupled to mass spectrometry. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 128, JUL 2020. Web of Science Citations: 0.
VASCONCELOS SOARES MACIEL, EDVALDO; MEJIA-CARMONA, KAREN; LANCAS, FERNANDO MAURO. Evaluation of Two Fully Automated Setups for Mycotoxin Analysis Based on Online Extraction-Liquid Chromatography-Tandem Mass Spectrometry. Molecules, v. 25, n. 12 JUN 2020. Web of Science Citations: 0.
MEJIA-CARMONA, KAREN; MACIEL, EDVALDO VASCONCELOS SOARES; LANCAS, FERNANDO MAURO. Miniaturized liquid chromatography applied to the analysis of residues and contaminants in food: A review. ELECTROPHORESIS, MAY 2020. Web of Science Citations: 0.
SOARES MACIEL, EDVALDO VASCONCELOS; DE TOFFOLI, ANA LUCIA; SOBIESKI, EDUARDO; DOMINGUES NAZARIO, CARLOS EDUARDO; LANCAS, FERNANDO MAURO. Miniaturized liquid chromatography focusing on analytical columns and mass spectrometry: A review. Analytica Chimica Acta, v. 1103, p. 11-31, MAR 22 2020. Web of Science Citations: 0.
SOARES MACIEL, EDVALDO VASCONCELOS; DE TOFFOLI, ANA LUCIA; ALVES, JUSSARA DA SILVA; LANCAS, FERNANDO MAURO. Multidimensional Liquid Chromatography Employing a Graphene Oxide Capillary Column as the First Dimension: Determination of Antidepressant and Antiepileptic Drugs in Urine. Molecules, v. 25, n. 5 MAR 1 2020. Web of Science Citations: 0.
DA SILVA BURATO, JULIANA SOARES; VARGAS MEDINA, DEYBER ARLEY; DE TOFFOLI, ANA LUCIA; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Recent advances and trends in miniaturized sample preparation techniques. JOURNAL OF SEPARATION SCIENCE, v. 43, n. 1, SI, p. 202-225, JAN 2020. Web of Science Citations: 0.
MEJIA-CARMONA, KAREN; DA SILVA BURATO, JULIANA SOARES; BASOLLI BORSATTO, JOAO VICTOR; DE TOFFOLI, ANA LUCIA; LACAS, FERNANDO MAURO. Miniaturization of liquid chromatography coupled to mass spectrometry 1. Current trends on miniaturized LC columns. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 122, JAN 2020. Web of Science Citations: 0.
DA SILVA BURATO, JULIANA SOARES; VARGAS MEDINA, DEYBER ARLEY; DE TOFFOLI, ANA LUCIA; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Recent advances and trends in miniaturized sample preparation techniques. JOURNAL OF SEPARATION SCIENCE, DEC 2019. Web of Science Citations: 0.
SOARES MACIEL, EDVALDO VASCONCELOS; DE TOFFOLI, ANA LUCIA; SOBIESKI NETO, EDUARDO; DOMINGUES NAZARIO, CARLOS EDUARDO; LANCAS, FERNANDO MAURO. New materials in sample preparation: Recent advances and future trends. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 119, OCT 2019. Web of Science Citations: 3.
DE TOFFOLI, ANA LUCIA; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Evaluation of the tubing material and physical dimensions on the performance of extraction columns for on-line sample preparation-LC-MS/MS. Journal of Chromatography A, v. 1597, p. 18-27, JUL 19 2019. Web of Science Citations: 0.
FRANCO, MARAISSA S.; PADOVAN, RODRIGO N.; FUMES, BRUNO H.; PALMER, CHRISTOPHER P.; MCGETTRICK, JULIE R.; LANCAS, FERNANDO M. Silica modified with polymeric amphiphilic nanoparticles as first dimension for multidimensional separation techniques. Journal of Chromatography A, v. 1597, p. 149-158, JUL 19 2019. Web of Science Citations: 0.
MEJIA-CARMONA, KAREN; JORDAN-SINISTERRA, MARCELA; LANCAS, FERNANDO M. Current Trends in Fully Automated On-Line Analytical Techniques for Beverage Analysis. BEVERAGES, v. 5, n. 1 MAR 2019. Web of Science Citations: 0.
SOARES MACIEL, EDVALDO VASCONCELOS; DE TOFFOLI, ANA LUCIA; LANCAS, FERNANDO MAURO. Current status and future trends on automated multidimensional separation techniques employing sorbent-based extraction columns. JOURNAL OF SEPARATION SCIENCE, v. 42, n. 1, p. 258-272, JAN 2019. Web of Science Citations: 3.
FERREIRA, DEBORA CECATTO; DE TOFFOLI, ANA LUCIA; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Online fully automated SPE-HPLC-MS/MS determination of ceftiofur in bovine milk samples employing a silica-anchored ionic liquid as sorbent. ELECTROPHORESIS, v. 39, n. 17, p. 2210-2217, SEP 2018. Web of Science Citations: 3.
SOARES MACIEL, EDVALDO VASCONCELOS; FUMES, BRUNO HENRIQUE; DE TOFFOLI, ANA LUCIA; LANCAS, FERNANDO MAURO. Graphene particles supported on silica as sorbent for residue analysis of tetracyclines in milk employing microextraction by packed sorbent. ELECTROPHORESIS, v. 39, n. 15, SI, p. 2047-2055, AUG 2018. Web of Science Citations: 3.
SOARES MACIEL, EDVALDO V.; DE TOFFOLI, ANA LUCIA; LANCAS, FERNANDO MAURO. Recent trends in sorption-based sample preparation and liquid chromatography techniques for food analysis. ELECTROPHORESIS, v. 39, n. 13, SI, p. 1582-1596, JUL 2018. Web of Science Citations: 5.
DE TOFFOLI, ANA LUCIA; SOARES MACIEL, EDVALDO VASCONCELOS; FUMES, BRUNO HENRIQUE; LANCAS, FERNANDO MAURO. The role of graphene-based sorbents in modern sample preparation techniques. JOURNAL OF SEPARATION SCIENCE, v. 41, n. 1, p. 288-302, JAN 2018. Web of Science Citations: 29.
DE TOFFOLI, ANA L.; FUMES, BRUNO H.; LANCAS, FERNANDO M. Packed in-tube solid phase microextraction with graphene oxide supported on aminopropyl silica: Determination of target triazines in water samples. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMIN, v. 53, n. 7, p. 434-440, 2018. Web of Science Citations: 7.
FUMES, BRUNO HENRIQUE; LANCAS, FERNANDO MAURO. Use of graphene supported on aminopropyl silica for microextraction of parabens from water samples. Journal of Chromatography A, v. 1487, p. 64-71, MAR 3 2017. Web of Science Citations: 16.
DOMINGUES NAZARIO, CARLOS EDUARDO; FUMES, BRUNO HENRIQUE; DA SILVA, MEIRE RIBEIRO; LANCAS, FERNANDO MAURO. New materials for sample preparation techniques in bioanalysis. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1043, p. 81-95, FEB 1 2017. Web of Science Citations: 19.
FUMES, BRUNO HENRIQUE; ANDRADE, MARIANE AISSA; FRANCO, MARAISSA SILVA; LANCAS, FERNANDO MAURO. On-line approaches for the determination of residues and contaminants in complex samples. JOURNAL OF SEPARATION SCIENCE, v. 40, n. 1, p. 183-202, JAN 2017. Web of Science Citations: 9.
FRANCO, MARAISSA SILVA; PADOVAN, RODRIGO NOGUEIRA; FUMES, BRUNO HENRIQUE; LANCAS, FERNANDO MAURO. An overview of multidimensional liquid phase separations in food analysis. ELECTROPHORESIS, v. 37, n. 13, SI, p. 1768-1783, JUL 2016. Web of Science Citations: 7.
FUMES, BRUNO HENRIQUE; ANDRADE, FELIPE NASCIMENTO; DOS SANTOS NETO, ALVARO JOSE; LANCAS, FERNANDO MAURO. Determination of pesticides in sugarcane juice employing microextraction by packed sorbent followed by gas chromatography and mass spectrometry. JOURNAL OF SEPARATION SCIENCE, v. 39, n. 14, p. 2823-2830, JUL 2016. Web of Science Citations: 10.
ANDRADE, FELIPE NASCIMENTO; DOMINGUES NAZARIO, CARLOS EDUARDO; SANTOS-NETO, ALVARO JOSE; LANCAS, FERNANDO MAURO. Development of on-line molecularly imprinted solid phase extraction-liquid chromatography-mass spectrometry for triazine analysis in corn samples. ANALYTICAL METHODS, v. 8, n. 5, p. 1181-1186, 2016. Web of Science Citations: 18.
NAZARIO, CARLOS E. D.; SILVA, MEIRE R.; FRANCO, MARAISSA S.; LANCAS, FERNANDO M. Evolution in miniaturized column liquid chromatography instrumentation and applications: An overview. Journal of Chromatography A, v. 1421, p. 18-37, NOV 20 2015. Web of Science Citations: 35.
FUMES, BRUNO HENRIQUE; SILVA, MEIRE RIBEIRO; ANDRADE, FELIPE NASCIMENTO; DOMINGUES NAZARIO, CARLOS EDUARDO; LANCAS, FERNANDO MAURO. Recent advances and future trends in new materials for sample preparation. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 71, n. SI, p. 9-25, SEP 2015. Web of Science Citations: 81.
SILVA, MEIRE R.; ANDRADE, FELIPE N.; FUMES, BRUNO H.; LANCAS, FERNANDO M. Unified chromatography: Fundamentals, instrumentation and applications. JOURNAL OF SEPARATION SCIENCE, v. 38, n. 17, p. 3071-3083, SEP 2015. Web of Science Citations: 5.

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