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Gene expression analysis of tissue health in subjects with clinical and subclinical thyroid dysfunction

Grant number: 14/04193-0
Support type:Regular Research Grants
Duration: August 01, 2014 - January 31, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Cléber Pinto Camacho
Grantee:Cléber Pinto Camacho
Home Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
Assoc. researchers:Humberto Dellê ; Ivone da Silva Duarte

Abstract

The tissue health is critical to the patients' clinical management. In the last years, the increment of the molecular biology knowledge reveled the exosomes as a noninvasive diagnostic strategy with power to analyze the tissue physiology. RNA detection with diagnostic purpose can overcome the traditional methods. Although less controversy follows the hypothyroidism treatment, the real need of T3 reposition with T4 dilemma and the subclinical disease controversy persist. Many steps are necessary to the thyroid hormone actions and any modification of this complex system can alter the T3 tissue response. Altered expression of 16 genes was found in blood samples of Graves Disease patients. Our goal is to identify differential expressed genes in healthy people and in hypothyroidism patients. Exosomes will be extracted and analyzed through whole genomic expression chip. The differential expressed genes will be validated in silica and in vivo. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE LIMA HIRATA, ANDREA HARUMY; DE JESUS ROCHA, LUIZ ANTONIO; DA SILVA, VALDELENA ALESSANDRA; DE ALMEIDA, ROBSON JOSE; BACIGALUPO, LUCAS DOS SANTOS; VARELA, PATRICIA; MARTINS, LEONARDO; PESQUERO, JOAO BOSCO; DELLE, HUMBERTO; CAMACHO, CLEBER PINTO. Circulating RNA Transcriptome of Pregnant Women with TSH Just Above the Trimester-Specific Reference and its Correlation with the Hypertensive Phenotype. SCIENTIFIC REPORTS, v. 10, n. 1, . (14/04193-0)
DA SILVA, VALDELENA ALESSANDRA; DE ALMEIDA, ROBSON JOSE; CAVALCANTE, MARCELE PIMENTA; PEREIRA JUNIOR, LUCIO ANTONIO; REIS, FRANCINE MACHADO; PEREIRA, MARIANA FABBRIS; KASAMATSU, TERESA S.; CAMACHO, CLEBER P.. Two Thyroid Stimulating Hormone assays correlated in clinical practice show disagreement in subclinical hypothyroidism patients. CLINICAL BIOCHEMISTRY, v. 53, p. 13-18, . (14/04193-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.