Weight cycling: mast cell role, vascular and tissue remodeling and inflammation resolution evaluation

• Grant number: 14/10141-3
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2014
• End date: March 31, 2017
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Alessandra Gambero
• Grantee: Alessandra Gambero
• Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil

Abstract

Weight loss dieting and bariatric surgery remains the choice for the obese individuals that needs weight loss. However, the most part of patients that lose weight present weight regain, phenomenon named weight cycling. Not all obesity alterations were reverted during weight loss and after a weight regain, some inflammatory markers were worsened when compared with mice that were all time obese. Thus, it is important to study the alterations associated with adipose tissue during the weight loss period and intervention that could be beneficial during weight regain. Obese mice submitted to a weight cycling have the same body composition and metabolic status than control ones, but they have elevated IL-6, leptin and reduced adiponectin in adipose tissue. Adipose tissue remodeling was also altered resulting in an increased adipocyte number, macrophage infiltration and T lymphocytes. There is no previous report about mast cell infiltration during weight loss or if mast cells could have a role during adipose tissue remodeling. Extracellular matrix alteration associated with tissue remodeling and alterations in adipogenesis and angiogenesis during weight cycling was not studied yet. In addition, there are a little data about inflammation resolution, i.e. protectins and resolvins, in adipose tissue during weight loss. So, the aim of this project is to study mast cell population, tissue and vascular remodeling and inflammation resolution process in adipose tissue during weight cycling in mice. It also aimed study intervention done during weight loss period as mast cell stabilization, tissue remodeling alterations and fatty acids n-3 supplementation (to improve the production of pro-resolving mediators). These approaches could result in new perspectives to help individuals that weight lost does not have bad results with regain weight period. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARIA, CINTIA RABELO E PAIVA; FERREIRA GOTARDO, ERICA MARTINS; SANTOS, PAOLA SOUZA; ACEDO, SIMONE COGHETTO; DE MORAIS, THAINA RODRIGUES; RIBEIRO, MARCELO LIMA; GAMBERO, ALESSANDRA. Extracellular matrix remodeling and matrix metalloproteinase inhibition in visceral adipoSe during weight cycling in mice. Experimental Cell Research, v. 359, n. 2, p. 431-440, OCT 15 2017. (14/10141-3)