Advanced search
Start date
Betweenand

The effect of bradykinin on osteoclastogenesis in vitro and LPS-induced bone resorption in vivo

Abstract

Besides the classical action of the kallikrein-kinin system (KKS) in the modulation of the vascular tonus, this system is also involved in different pathologies, some of them being inflammatory in nature. Inflammatory processes in the vicinity of the skeleton generally leads to bone loss, and in vitro models demonstrate that kinins may participate of inflammatory bone resorption by activating the B1 and B2 kinin receptors. In contrast with these findings, some in vivo studies demonstrate an inhibitory role of the KKS on bone resorption and osteoclast differentiation. Since several drugs having the KKS as target are available in the market, the knowledge about the mechanisms underlying the role of kinins on bone resorption is very important to predict side effects and develop new drugs. Therefore, the aim of the present project is to analyze the role of kinins on LPS-induced bone resorption in vivo and the role of kinins on osteoclastogenesis in vitro. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HENNING, PETRA; MOVERARE-SKRTIC, SOFIA; WESTERLUND, ANNA; CHAVES DE SOUZA, PEDRO PAULO; FLORIANO-MARCELINO, THAIS; NILSSON, KARIN H.; EL SHAHAWY, MAHA; OHLSSON, CLAES; LERNER, ULF H.. WNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M. JOURNAL OF INFLAMMATION RESEARCH, v. 14, p. 4723-4741, . (15/00410-0, 14/05283-3)
LEGUIZAMON, N. DA PONTE; DE MOLO, R. S.; COLETTO-NUNES, G.; NOGUEIRA, A. V. B.; ROCHA, V, S.; NEO-JUSTINO, D. M.; SOARES-COSTA, A.; CERRI, P. S.; LERNER, U. H.; SOUZA, P. P. C.; et al. hytocystatin CsinCPI-2 Reduces Osteoclastogenesis and Alveolar Bone Los. JOURNAL OF DENTAL RESEARCH, v. 101, n. 2, . (14/05283-3, 18/10727-9, 18/10728-5, 16/09876-4, 15/21697-5)
SOUZA, PEDRO P. C.; LUNDBERG, PERNILLA; LUNDGREN, INGER; MAGALHAES, FERNANDO A. C.; COSTA-NETO, CLAUDIO M.; LERNER, ULF H.. Activation of Toll-like receptor 2 induces B1 and B2 kinin receptors in human gingival fibroblasts and in mouse gingiva. SCIENTIFIC REPORTS, v. 9, . (14/05283-3)
TEIXEIRA, JORGE FELIPE LIMA; DE SOUZA, JOAO ANTONIO CHAVES; MAGALHAES, FERNANDO AUGUSTO CINTRA; DE OLIVEIRA, GUILHERME JOSE PIMENTEL LOPES; DE SANTIS, JOSE BERNARDO; COSTA, CARLOS ALBERTO DE SOUZA; DE SOUZA, PEDRO PAULO CHAVES. Laser-Modified Ti Surface Improves Paracrine Osteogenesis by Modulating the Expression of DKK1 in Osteoblasts. JOURNAL OF FUNCTIONAL BIOMATERIALS, v. 14, n. 4, p. 12-pg., . (14/05283-3, 17/22739-9)
JOÃO ANTONIO CHAVES DE SOUZA; FERNANDO AUGUSTO CINTRA MAGALHÃES; GUILHERME JOSE PIMENTEL LOPES DE OLIVEIRA; RAFAEL SCAF DE MOLON; JOSÉ ANTONIO ZUANON; PEDRO PAULO CHAVES DE SOUZA. Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice. Brazilian Oral Research, v. 34, . (15/21697-5, 14/05283-3)
PERSSON, EMMA; SOUZA, PEDRO P. C.; FLORIANO-MARCELINO, THAIS; CONAWAY, HOWARD HERSCHEL; HENNING, PETRA; LERNER, ULF H.. Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor. FRONTIERS IN IMMUNOLOGY, v. 10, . (14/05283-3, 15/00410-0)
MOVERARE-SKRTIC, SOFIA; NILSSON, KARIN H.; HENNING, PETRA; FUNCK-BRENTANO, THOMAS; NETHANDER, MARIA; RIVADENEIRA, FERNANDO; NUNES, GLAUCIA COLETTO; KOSKELA, ANTTI; TUUKKANEN, JUHA; TUCKERMANN, JAN; et al. Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans. FASEB JOURNAL, v. 33, n. 10, p. 11163-11179, . (14/05283-3)
CHAVES DE SOUZA, JOAO ANTONIO; CINTRA MAGALHAES, FERNANDO AUGUSTO; PIMENTEL LOPES DE OLIVEIRA, GUILHERME JOSE; DE MOLON, RAFAEL SCAF; ZUANON, JOSE ANTONIO; CHAVES DE SOUZA, PEDRO PAULO. Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice. BRAZILIAN ORAL RESEARCH, v. 34, p. 10-pg., . (15/21697-5, 14/05283-3)
DE SOUZA, PEDRO P. C.; HENNING, PETRA; LERNER, ULF H.. Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 6, p. 22-pg., . (14/05283-3, 15/00410-0)
SOUZA, PEDRO P. C.; LERNER, ULF H.. Finding a Toll on the Route: The Fate of Osteoclast Progenitors After Toll-Like Receptor Activation. FRONTIERS IN IMMUNOLOGY, v. 10, . (14/05283-3)

Please report errors in scientific publications list using this form.