Biodiversity components, and its metabolic characters, of Brazilian Islands

• Grant number: 13/50228-8
• Support type: BIOTA-FAPESP Program - Thematic Grants
• Duration: November 01, 2014 - October 31, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Roberto Gomes de Souza Berlinck
• Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Co-Principal Investigators: André Gustavo Tempone Cardoso ; Edson Rodrigues Filho
• Associated grant(s): 15/50075-2 - Brazilian biodiversity as a source for novel drug scaffolds against neglected protozoan diseases, AP.R SPRINT; 15/01017-0 - Multi-use instrument approved and awarded in the project 2013/50228-8, name of instrument: ultra-performance liquid chromatograph coupled with a high resolution mass spectrometer, AP.EMU
• Associated scholarship(s): 15/02820-0 - Synthesis of antileishmanial and antiChagas agents for drug prototypal development, BP.PD; 14/17616-7 - Phylogenetic and functional characterization of microbial communities associated with sponges that present bromopyrrole alkaloids and characterization of gene clusters which include Nonribossomal peptide synthetase (NRPS), BP.PD

Abstract

Islands represent about 5% of the Erath’s land cover. With a very particular biodiversity, islands are considered true microcosms of the continents. The islands’ natural environment very often present a variety of endemic species, which are particularly vulnerable. Therefore, the importance of biodiversity conservation of biological species present on islands is extreme. The marine biodiversity of the South Atlantic west coast, where Brazil is located, it is still essentially unknown. The anthropogenic impacts observed in the Brazilian coastal region are of increasing intensity. Coastal and oceanic Brazilian islands have submerged marine environments somewhat better preserved that the coastline ones. Taking into account the diversity of species estimated for such islands, the study of its biodiversity is most necessary and should be conducted jointly with bioprospecting activities. This project aims to answer four questions: 1. Macro-organics of different biological group (sponges, ascidians, cnidarians, bryozoans and mollusks) found in different islands of Brazil exhibit a distinct pattern of occurrence or distribution than at the coastline? 2. Micro-organisms associated with invertebrates and with plant islands exhibit an occurrence of species different from that observed in coastal environments? 3. Among the macro- and micro-organisms that will be chemically, biochemically and biotechnologically investigated, are their secondary metabolites and enzimes characteristically unique of organisms found on islands and archipelagos, due to relative geographic isolation of the species present in these environments, or have biogenetic relationships and/or occurrences or similar biochemical characters of related species found on the continent? 4. The frequency of the occurrence of bioactive substances in organisms from islands is higher than in organisms from the coasts? In order to answer such questions, fauna surveys associated with studies of biodiversity, taxonomy, phylogeography, bioprospecting, microbiology and metagenomic analyses will be performed. Particular emphasis will be applied to the survey and description of invertebrate species to be found in sites still poorly explored. Such strategy aims: the isolation of “exotic” microbial strains using different approaches for growth in culture media; the isolation of novel bioactive metabolites using dereplication tools and refined analyses of chemical profiles (by UPLC-UV-MS/MS); the investigation of specific cases of micr-organism/macro-organism interactions that may be related to metabolism expression of one or both parties, using metagenomic techniques associated with metabolomics analyses of specific biological groups. (AU)

Scientific publications

(43)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GRIGOLETTO, DIANA F.; TRIVELLA, DANIELA B. B.; TEMPONE, ANDRE G.; RODRIGUES, ANDRE; CORREIA, ANA MARIA L.; LIRA, SIMONE P. Antifungal compounds with anticancer potential from Trichoderma sp. P8BDA1F1, an endophytic fungus from Begonia venosa. Brazilian Journal of Microbiology, APR 2020. Web of Science Citations: 0.

CHIMETTO TONON, LUCIANE A.; DE AZEVEDO, GUSTAVO P. R.; MONTEIRO, AFIF F.; BERNARDI, I, DARLON; GUBIANI, JULIANA R.; IOCA, LAURA P.; MATTSSON, HANNAH K.; MOREIRA, ANA PAULA B.; GOMES, ALEXANDRE F.; PIRES JUNIOR, OSMINDO R.; PEDROSA, CAROLINA DA S. G.; SOUZA, LETICIA R. Q.; REHEN, STEVENS K.; THOMPSON, CRISTIANE C.; THOMPSON, FABIANO L.; BERLINCK, ROBERTO G. S. New tetrodotoxin analogs in Brazilian pufferfishes tissues and microbiome. Chemosphere, v. 242, MAR 2020. Web of Science Citations: 0.

RODRIGUEZ, JULIE P. G.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; DE OLIVEIRA, JULIANA MAGALHAES; MORAIS-URANO, RAQUEL P.; BERTONHA, ARIANE F.; BANDEIRA, KARIN F.; BULLA, JAIRO I. Q.; SETTE, LARA D.; FERREIRA, ANTONIO G.; BATISTA, JR., JOAO M.; SILVA, THAYNA DE SOUZA; DOS SANTOS, RAQUEL ALVES; MARTINS, CARLOS H. G.; LIRA, SIMONE P.; DA CUNHA, MARCOS G.; TRIVELLA, DANIELA B. B.; GRAZZIA, NATHALIA; GOMES, NATALIA E. S.; GADELHA, FERNANDA; MIGUEL, DANILO C.; CAUZ, ANA CAROLINA G.; BROCCHI, MARCELO; BERLINCK, ROBERTO G. S. Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica. Journal of Natural Products, v. 83, n. 1, p. 55-65, JAN 2020. Web of Science Citations: 0.

ORR, RUSSELL J. S.; HAUGEN, MARIANNE N.; BERNING, BOEJRN; BOCK, PHILIP; CUMMING, ROBYN L.; FLORENCE, WAYNE K.; HIROSE, MASATO; DI MARTINO, EMANUELA; RAMSFJELL, MALI H.; SANNUM, MAJA M.; SMITH, ABIGAIL M.; VIEIRA, LEANDRO M.; WAESCHENBACH, ANDREA; LIOW, LEE HSIANG. A genome-skimmed phylogeny of a widespread bryozoan family, Adeonidae. BMC Evolutionary Biology, v. 19, n. 1 DEC 27 2019. Web of Science Citations: 0.

FREIRE, VITOR F.; SLIVINSKI, JULIANO; QUINTANA-BULLA, JAIRO I.; MORAES, FERNANDO C.; PARADAS, WLADIMIR C.; SALGADO, LEONARDO T.; PEREIRA, RENATO C.; MOURA, RODRIGO L.; AMADO-FILHO, GILBERTO M.; FERREIRA, ANTONIO G.; BERLINCK, ROBERTO G. S. Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 29, n. 6, p. 715-719, NOV-DEC 2019. Web of Science Citations: 0.

AZEVEDO, GUSTAVO P. R.; MATTSSON, HANNAH K.; APPOLINARIO, LUCIANA R.; CALEGARIO, GABRIELA; LEOMIL, LUCIANA; WALTER, JULINE M.; CAMPEAO, MARIANA; CHIMETTO TONON, LUCIANE A.; MOREIRA, ANA PAULA B.; VIDAL, LIVIA; VIEIRA, VERONICA V.; OTSUKI, KOKO; TSCHOEKE, DIOGO A.; SWINGS, JEAN; THOMPSON, FABIANO L.; THOMPSON, CRISTIANE C. Enterovibrio baiacu sp. nov.. Current Microbiology, OCT 2019. Web of Science Citations: 0.

GUBIANI, JULIANA R.; OLIVEIRA, MICHELE C. S.; NEPONUCENO, RICARDO A. R.; CAMARGO, MARIA J.; GARCEZ, WALMIR S.; BIZ, ANDRESSA R.; SOARES, MARCOS A.; ARAUJO, ANGELA R.; BOLZANI, VANDERLAN DA S.; LISBOA, HELEN C. F.; DE SOUSA JR, PAULO T.; DE VASCONCELOS, LEONARDO G.; RIBEIRO, TEREZA A. N.; DE OLIVEIRA, JULIANA M.; BANZATO, THAIS P.; LIMA, CAROLINA A.; LONGATO, GIOVANNA B.; BATISTA JR, JOAO M.; BERLINCK, ROBERTO G. S.; TELES, HELDER L. Cytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63. PHYTOCHEMISTRY LETTERS, v. 32, p. 162-167, AUG 2019. Web of Science Citations: 0.

BERLINCK, ROBERTO G. S.; MONTEIRO, AFIF F.; BERTONHA, ARIANE F.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; SLIVINSKI, JULIANO; MICHALISKI, LAMONIELLI F.; TONON, LUCIANE A. C.; VENANCIO, VICTOR A.; FREIRE, VITOR F. Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products. NATURAL PRODUCT REPORTS, v. 36, n. 7, p. 981-1004, JUL 1 2019. Web of Science Citations: 2.

DOS REIS, GISLAINE VICENTE; ABRAHAM, WOLF-RAINER; GRIGOLETTO, DIANA FORTKAMP; DE CAMPOS, JESSICA BUENO; MARCON, JOELMA; DA SILVA, JOSE ANTONIO; QUECINE, MARIA CAROLINA; DE AZEVEDO, JOAO LUCIO; FERREIRA, ANTONIO GILBERTO; DE LIRA, SIMONE POSSEDENTE. Gloeosporiocide, a new antifungal cyclic peptide from Streptomyces morookaense AM25 isolated from the Amazon bulk soil. FEMS Microbiology Letters, v. 366, n. 14 JUL 2019. Web of Science Citations: 0.

DA CRUZ, RICHTIER GONCALVES; BENEY, LAURENT; GERVAIS, PATRICK; DE LIRA, SIMONE POSSEDENTE; FERREIRA DE SOUZA VIEIRA, THAIS MARIA; DUPONT, SEBASTIEN. Comparison of the antioxidant property of acerola extracts with synthetic antioxidants using an in vivo method with yeasts. Food Chemistry, v. 277, p. 698-705, MAR 30 2019. Web of Science Citations: 8.

SLIVINSKI, JULIANO; SANTOS, MARIO F. C.; FERREIRA, ANTONIO G.; BERLINCK, ROBERTO G. S. Brotasic Acid Methyl Ester from the Fruiting Bodies of the Mushroom Auricularia sp. PHYTOCHEMISTRY LETTERS, v. 29, p. 91-93, FEB 2019. Web of Science Citations: 0.

MARCIANO CORREA, JOZE APARECIDA; FORTKAMP, DIANA; DA SILVA, CAMILA FURTUNATO; ROCHA, FLAVIO; GOMES, LUIZ HUMBERTO; RONCATO DUARTE, KEILA MARIA; FERREIRA, ANTONIO GILBERTO; DE LIRA, SIMONE POSSEDENTE. Biological activity of 7 beta-acetoxywithanolide D isolated from Acnistus arborescens. SEMINA-CIENCIAS AGRARIAS, v. 39, n. 6, p. 2835-2841, NOV-DEC 2018. Web of Science Citations: 0.

DE SOUZA, RENATA T. M. P.; FREIRE, VITOR F.; GUBIANI, JULIANA R.; FERREIRA, RAQUEL O.; TRIVELLA, DANIELA B. B.; MORAES, FERNANDO C.; PARADAS, WLADIMIR C.; SALGADO, LEONARDO T.; PEREIRA, RENATO C.; AMADO FILHO, GILBERTO M.; FERREIRA, ANTONIO G.; WILLIAMS, DAVID E.; ANDERSEN, RAYMOND J.; MOLINSKI, TADEUSZ F.; BERLINCK, ROBERTO G. S. Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp Marine Sponge Collected at the Amazon River Mouth. Journal of Natural Products, v. 81, n. 10, p. 2296-2300, OCT 2018. Web of Science Citations: 1.

ELIAS, LUCIANA M.; FORTLZAMP, DIANA; SARTORI, SERGIO B.; FERREIRA, MARILIA C.; GOMES, LUIZ H.; AZEVEDO, JOAO L.; MONTOYA, V, QUIMI; RODRIGUES, ANDRE; FERREIRA, ANTONIO G.; LIRA, SIMONE P. The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnose. Brazilian Journal of Microbiology, v. 49, n. 4, p. 840-847, OCT-DEC 2018. Web of Science Citations: 2.

RUA, CINTIA P. J.; DE OLIVEIRA, LOUISI S.; FROES, ADRIANA; TSCHOEKE, DIOGO A.; SOARES, ANA CAROLINA; LEOMIL, LUCIANA; GREGORACCI, GUSTAVO B.; COUTINHO, RICARDO; HAJDU, EDUARDO; THOMPSON, CRISTIANE C.; BERLINCK, ROBERTO G. S.; THOMPSON, FABIANO L. Microbial and Functional Biodiversity Patterns in Sponges that Accumulate Bromopyrrole Alkaloids Suggest Horizontal Gene Transfer of Halogenase Genes. MICROBIAL ECOLOGY, v. 76, n. 3, p. 825-838, OCT 2018. Web of Science Citations: 3.

NEWMISTER, SEAN A.; ROMMINGER, STELAMAR; SCHMIDT, JENNIFER J.; WILLIAMS, ROBERT M.; SMITH, JANET L.; BERLINCK, ROBERTO G. S.; SHERMAN, DAVID H. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 16, n. 35, p. 6450-6459, SEP 21 2018. Web of Science Citations: 6.

KURODA, YUSUKE; NICACIO, KAREN J.; DA SILVA-, JR., ILDEFONSO ALVES; LEGER, PAUL R.; CHANG, STANLEY; GUBIANI, JULIANA R.; DEFLON, VICTOR M.; NAGASHIMA, NOZOMU; RODE, ALEXANDER; BLACKFORD, KATHERINE; FERREIRA, ANTONIO G.; SETTE, LARA D.; WILLIAMS, DAVID E.; ANDERSEN, RAYMOND J.; JANCAR, SONIA; BERLINCK, ROBERTO G. S.; SARPONG, RICHMOND. Isolation, synthesis and bioactivity studies of phomactin terpenoids. NATURE CHEMISTRY, v. 10, n. 9, p. 938-945, SEP 2018. Web of Science Citations: 7.

THOMPSON, FABIANO; KRUGER, RICARDO; THOMPSON, CRISTIANE C.; BERLINCK, ROBERTO G. S.; COUTINHO, RICARDO; LANDELL, MELISSA F.; PAVAO, MAURO; MOURAO, PAULO A. S.; SALLES, ANA; NEGRI, NAIANE; LOPES, FABYANO A. C.; FREIRE, VITOR; MACEDO, ALEXANDRE J.; MARASCHIN, MARCELO; PEREZ, CARLOS D.; PEREIRA, RENATO C.; RADIS-BAPTISTA, GANDHI; REZENDE, RACHEL P.; VALENTI, WAGNER C.; ABREU, PAULO C.; FRANCINI-FO, RONALDO; ASP, NILS; SIEGLE, EDUARDO; REZENDE, CARLOS E.; SCHENKEL, ELOIR; LHULLIER, CINTIA; DIAS, JOAO; BROETTO, LEONARDO; GOMES, PAULA BRAGA; CORDEIRO, RALF TARCISO; DE ANDRADE MELO, LIANY FIGUEREDO; VASCONCELOS, ANA TEREZA; GADELHA, LUIZ; SOARES, ANDREIMAR; MEIRELLES, PEDRO; TSCHOEKE, DIOGO; GARCIA, GIZELE; VICENTE, ANA CAROLINA; VIEIRA, VERONICA; MIRANDA, MILENE; GREGORACCI, GUSTAVO; SANTOS CARTAXO, ADRIANA NASCIMENTO; COLONELLO FRATTINI, NINIVE AGUIAR; GEORGES, SIDDHARTHA; POLEJACK, ANDREI; CHIMETTO, LUCIANE; DE OLIVEIRA, LOUISI; LEOMIL, LUCIANA; REIS, LUCIANA; CALEGARIO, GABRIELA; MOREIRA, ANA PAULA; SOARES, ANA CAROLINA; COSTA, ANA CAROLINA; SILVA, BRUNO SERGIO; LIMA, ARTHUR WEISS; OTZUKI, KOKO; WALTER, JULINE MARTA; BAHIENSE, LAURA; MACHADO, ANDRE; SANTOS, EIDY; NOBREGA, MARIA SOARES; COUTINHO, FELIPE; VIDAL, LIVIA; MATTOSO, MARTA; THOMPSON, MATEUS; CAMPEAO, MARIANA; VARASTE, TOOBA; PITTA, GUSTAVO; PAIXAO, RAPHAEL; MATTSSON, HANNAH; VENAS, TAINA; HADELK, CAMILA; FREITAS, THAMYRES; LOPES, GRASIELA; PAZ, PEDRO; SILVEIRA, CYNTHIA; CAVALCANTI, GISELLE; FROES, ADRIANA MACHADO; FREITAS, LUCAS; VIZZOTTO, CARLA; PINTO, OTAVIO; VILEGAS, WAGNER; COSTA, TANIA MARCIA; DE CASTRO, LEANDRO MANTOVANI; AUGUSTO, ALESSANDRA DA SILVA; RORIG, LEONARDO; DERNER, ROBERTO BIANCHINI; HAJDU, EDUARDO; LEAL, CAMILA; NETWORK, BIOTECMAR. Marine Biotechnology in Brazil: Recent Developments and Its Potential for Innovation. FRONTIERS IN MARINE SCIENCE, v. 5, JUL 9 2018. Web of Science Citations: 2.

DA CRUZ, RICHTIER GONCALVES; FERREIRA DE SOUZA VIEIRA, THAIS MARIA; DE LIRA, SIMONE POSSEDENTE. Potential antioxidant of brazilian coffee from the region of Cerrado. FOOD SCIENCE AND TECHNOLOGY, v. 38, n. 3, p. 447-453, JUL-SEP 2018. Web of Science Citations: 4.

RICHTIER GONÇALVES DA CRUZ; THAIS MARIA FERREIRA DE SOUZA VIEIRA; SIMONE POSSEDENTE DE LIRA. Potential antioxidant of brazilian coffee from the region of Cerrado. FOOD SCIENCE AND TECHNOLOGY, v. 38, n. 3, p. -, Jul. 2018.

IOCA, LAURA P.; NICACIO, KAREN J.; BERLINCK, ROBERTO G. S. Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards. Journal of the Brazilian Chemical Society, v. 29, n. 5, p. 998-1031, MAY 2018. Web of Science Citations: 2.

CORREIA, ANA M. L.; LIRA, SIMONE P.; ASSIS, MARCO A.; RODRIGUES, ANDRE. Fungal Endophyte Communities in Begonia Species from the Brazilian Atlantic Rainforest. Current Microbiology, v. 75, n. 4, p. 441-449, APR 2018. Web of Science Citations: 1.

FROES, ADRIANA M.; FREITAS, THAMYRES C.; VIDAL, LIVIA; APPOLINARIO, LUCIANA R.; LEOMIL, LUCIANA; VENAS, TAINA; CAMPEAO, MARIANA E.; SILVA, CARLOS J. F.; MOREIRA, ANA PAULA B.; BERLINCK, ROBERTO G. S.; THOMPSON, FABIANO L.; THOMPSON, CRISTIANE C. Genomic Attributes of Novel Symbiont Pseudovibrio brasiliensis sp. nov. Isolated From the Sponge Arenosclera brasiliensis. FRONTIERS IN MARINE SCIENCE, v. 5, MAR 12 2018. Web of Science Citations: 0.

PARRA, LIZBETH L. L.; BERTONHA, ARIANE F.; SEVERO, IVAN R. M.; AGUIAR, ANNA C. C.; DE SOUZA, GUILHERME E.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; GRAZZIA, NATHALIA; COSTA, TABATA R.; MIGUEL, DANILO C.; GADELHA, FERNANDA R.; FERREIRA, ANTONIO G.; HAJDU, EDUARDO; ROMO, DANIEL; BERLINCK, ROBERTO G. S. Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis. Journal of Natural Products, v. 81, n. 1, p. 188-202, JAN 2018. Web of Science Citations: 3.

GRECCO, SIMONE S.; COSTA-SILVA, THAIS A.; JERZ, GEROLD; DE SOUSA, FERNANDA S.; LONDERO, VINICIUS S.; GALUPPO, MARIANA K.; LIMA, MARTA L.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G. Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages. Chemico-Biological Interactions, v. 277, p. 55-61, NOV 1 2017. Web of Science Citations: 8.

MARTINS, DANUBIA BATISTA; VIEIRA, MAIRA RAMOS; FADEL, VALMIR; CAMARGO SANTANA, VIVIANE APARECIDA; RODRIGUES GUERR, MIRIAN ELISA; LIMA, MARTA LOPES; TEMPONE, ANDRE G.; DOS SANTOS CABRERA, MARCIA PEREZ. Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 11, A, p. 2861-2871, NOV 2017. Web of Science Citations: 1.

VARELA, MARINA T.; LIMA, MARTA L.; GALUPPO, MARIANA K.; TEMPONE, ANDRE G.; DE OLIVEIRA, ALBERTO; LAGO, JOAO HENRIQUE G.; FERNANDES, JOAO PAULO S. New alkenyl derivative from Piper malacophyllum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum. CHEMICAL BIOLOGY & DRUG DESIGN, v. 90, n. 5, p. 1007-1011, NOV 2017. Web of Science Citations: 8.

ANDREOTE, FERNANDO DINI; PEREIRA E SILVA, MICHELE DE CASSIA. Microbial communities associated with plants: learning from nature to apply it in agriculture. Current Opinion in Microbiology, v. 37, p. 29-34, JUN 2017. Web of Science Citations: 26.

ALEXANDRE, TATIANA RODRIGUES; LIMA, MARTA LOPES; GALUPPO, MARIANA KOLOS; MESQUITA, JULIANA TONINI; DO NASCIMENTO, MATILIA ANA; DOS SANTOS, AUGUSTO LEONARDO; SARTORELLI, PATRICIA; PIMENTA, DANIEL CARVALHO; TEMPONE, ANDRE GUSTAVO. Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 23, n. 1 MAY 30 2017. Web of Science Citations: 4.

WULSTEN, IMKE E.; COSTA-SILVA, THAIS A.; MESQUITA, JULIANA T.; LIMA, MARTA L.; GALUPPO, MARIANA K.; TANIWAKI, NOEMI N.; BORBOREMA, SAMANTA E. T.; DA COSTA, FERNANDO B.; SCHMIDT, THOMAS J.; TEMPONE, ANDRE G. Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones. Molecules, v. 22, n. 5 MAY 2017. Web of Science Citations: 9.

DA COSTA-SILVA, THAIS ALVES; GALISTEO, JR., ANDRES JIMENEZ; LAULETTA LINDOSO, JOSE ANGELO; BARBOSA, LEANDRO R. S.; TEMPONE, ANDRE GUSTAVO. Nanoliposomal Buparvaquone Immunomodulates Leishmania infantum-Infected Macrophages and Is Highly Effective in a Murine Model. Antimicrobial Agents and Chemotherapy, v. 61, n. 4 APR 2017. Web of Science Citations: 8.

RAMIREZ, MARIA CAMILA A.; WILLIAMS, DAVID E.; GUBIANI, JULIANA R.; PARRA, LIZBETH L. L.; SANTOS, MARIO F. C.; FERREIRA, DAIANE D.; MESQUITA, JULIANA T.; TEMPONE, ANDRE G.; FERREIRA, ANTONIO G.; PADULA, VINICIUS; HAJDU, EDUARDO; ANDERSEN, RAYMOND J.; BERLINCK, ROBERTO G. S. Rearranged Terpenoids from the Marine Sponge Darwinella cf. oxeata and Its Predator, the Nudibranch Felimida grahami. Journal of Natural Products, v. 80, n. 3, SI, p. 720-725, MAR 2017. Web of Science Citations: 5.

NICACIO, KAREN J.; IOCA, LAURA P.; FROES, ADRIANA M.; LEOMIL, LUCIANA; APPOLINARIO, LUCIANA R.; THOMPSON, CHRISTIANE C.; THOMPSON, FABIANO L.; FERREIRA, ANTONIO G.; WILLIAMS, DAVID E.; ANDERSEN, RAYMOND J.; EUSTAQUIO, ALESSANDRA S.; BERLINCK, ROBERTO G. S. Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges. Journal of Natural Products, v. 80, n. 2, p. 235-240, FEB 2017. Web of Science Citations: 20.

Potential antioxidant of brazilian coffee from the region of Cerrado. FOOD SCIENCE AND TECHNOLOGY, n. ahead, p. -, 2017.

TATIANA RODRIGUES ALEXANDRE; MARTA LOPES LIMA; MARIANA KOLOS GALUPPO; JULIANA TONINI MESQUITA; MATILIA ANA DO NASCIMENTO; AUGUSTO LEONARDO DOS SANTOS; PATRICIA SARTORELLI; DANIEL CARVALHO PIMENTA; ANDRE GUSTAVO TEMPONE. Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 23, p. -, 2017.

NEWMISTER, SEAN A.; GOBER, CLAIRE M.; ROMMINGER, STELAMAR; YU, FENGAN; TRIPATHI, ASHOOTOSH; PARRA, LIZBETH LORENA L.; WILLIAMS, ROBERT M.; BERLINCK, ROBERTO G. S.; JOULLIE, MADELEINE M.; SHERMAN, DAVID H. OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30. Journal of the American Chemical Society, v. 138, n. 35, p. 11176-11184, SEP 7 2016. Web of Science Citations: 12.

MARTINS, LIGIA F.; MESQUITA, JULIANA T.; PINTO, ERIKA G.; COSTA-SILVA, THAIS A.; BORBOREMA, SAMANTA E. T.; GALISTEO JUNIOR, ANDRES J.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; AL SHUHAIB, ZAINAB; BENNETT, ELLIOT L.; BLACK, GREGORY P.; HARPER, PHILIP M.; EVANS, DANIEL M.; FITURI, HISHAM S.; LEYLAND, JOHN P.; MARTIN, CLAIRE; ROBERTS, TERENCE D.; THORNHILL, ANDREW J.; VALE, STEPHEN A.; HOWARD-JONES, ANDREW; THOMAS, DAFYDD A.; WILLIAMS, HARRI L.; OVERMAN, LARRY E.; BERLINCK, ROBERTO G. S.; MURPHY, PATRICK J.; TEMPONE, ANDRE G. Analogues of Marine Guanidine Alkaloids Are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania (L.) infantum Intracellular Amastigotes. Journal of Natural Products, v. 79, n. 9, p. 2202-2210, SEP 2016. Web of Science Citations: 15.

LAURA P. IÓCA; STELAMAR ROMMINGER; MARIO F. C. SANTOS; KARIN F. BANDEIRA; FABIANA T. RODRIGUES; MIRIAM H. KOSSUGA; KAREN J. NICACIO; EVERTON L. F. FERREIRA; RAQUEL P. MORAIS-URANO; MESSIAS S. PASSOS; LUCIANA K. KOHN; CLARICE W. ARNS; LARA D. SETTE; ROBERTO G. S. BERLINCK. A STRATEGY FOR THE RAPID IDENTIFICATION OF FUNGAL METABOLITES AND THE DISCOVERY OF THE ANTIVIRAL ACTIVITY OF PYRENOCINE A AND HARZIANOPYRIDONE. Química Nova, v. 39, n. 6, p. 720-731, Jul. 2016. Web of Science Citations: 1.

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