Evaluation of ovarian reserve, antibody anti-corpus luteum, cervicovaginal cytology, lower genital tract infections, metabolomics and ovulatory dysfunction in women with juvenile idiopathic arthritis

• Grant number: 14/14806-0
• Support Opportunities: Regular Research Grants
• Duration: November 01, 2014 - January 31, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Clovis Artur Almeida da Silva
• Grantee: Clovis Artur Almeida da Silva
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Claudia Goldenstein Schainberg ; Edmund Chada Baracat ; Eloisa Silva Dutra de Oliveira Bonfá ; Gustavo Arantes Rosa Maciel ; Rosa Maria Rodrigues Pereira

Abstract

Juvenile idiopathic arthritis (JIA) is a group of diseases characterized by arthritis of unknown origin with onset before 16 years of age, the most common chronic rheumatic disease in childhood . Treatment with drugs modifying the course of disease, particularly methotrexate (MTX) and biological agents is allowing better prognosis and raises issues related to gonadal function in young patients. Recently, it was observed that high cumulative doses of MTX reduced ovarian reserve in patients with systemic lupus erythematosus, juvenile onset , and the presence of anti-corpus luteum antibody were associated. The recent advance of metabolomics technology has also allowed the identification of several biomarkers related to chronic diseases, including seven classes of components : prostaglandins, steroid hormones, acylcarnitines, aminoacids, biogenic amines and hexoses phospho and sphingolipids. However, there is no study evaluating the interference of these metabolites on ovarian reserve in patients with JIA. Despite the higher prevalence of cervicovaginal abnormalities in patients with systemic lupus erythematosus, no study has evaluated these changes and the presence of lower genital tract infections in patients with JIA. Moreover, a considerable part of the population with JIA using anti -inflammatory non-steroidal drugs (NSAIDs) to control the disease. These drugs can induce ovulatory dysfunction in women, but no studies have evaluated this change in JIA patients on chronic NSAID use. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, V, GABRIELA R.; TOMIOKA, RENATO B.; QUEIROZ, LIGIA B.; KOZU, KATIA; AIKAWA, NADIA E.; SALLUM, ADRIANA M. E.; SERAFINI, PAULO; TACLA, MARICY; BARACAT, EDMUND C.; PEREIRA, ROSA M. R.; et al. Lower genital tract infections in young female juvenile idiopathic arthritis patients. ADVANCES IN RHEUMATOLOGY, v. 59, n. 1, NOV 15 2019. (15/03756-4, 14/14806-0)

BENITO LOURENÇO; KATIA T. KOZU; GABRIELA N. LEAL; MARCO F. SILVA; ELISABETH G.C. FERNANDES; CAMILA M.P. FRANÇA; FERNANDO H.C. SOUZA; CLOVIS A. SILVA. Contracepção para adolescentes com doenças reumáticas crônicas. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 57, n. 1, p. 73-81, 2017-02-00. (11/12471-2, 14/14806-0)

SILVA, CLOVIS ARTUR; AIKAWA, NADIA EMI; RODRIGUES PEREIRA, ROSA MARIA; ARRUDA CAMPOS, LUCIA MARIA. Management considerations for childhood-onset systemic lupus erythematosus patients and implications on therapy. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, v. 12, n. 3, p. 301-313, MAR 3 2016. (14/14806-0)

FERREIRA, GABRIELA R. V.; TOMIOKA, RENATO B.; AIKAWA, NADIA E.; LEON, ELAINE P.; MACIEL, GUSTAVO A. R.; SERAFINI, PAULO C.; BARACAT, EDMUND C.; GOLDENSTEIN-SCHAINBERG, CLAUDIA; PEREIRA, ROSA M. R.; BONFA, ELOISA; et al. Ovarian reserve in young juvenile idiopathic arthritis patients. MODERN RHEUMATOLOGY, v. 29, n. 3, p. 447-451, MAY 4 2019. (15/03756-4, 14/14806-0)

BRUNELLI, JULIANA BARBOSA; SCHMIDT, ANA RENATA; SALLUM, ADRIANA MALUF ELIAS; GOLDENSTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; SILVA, CLOVIS A.; AIKAWA, NADIA EMI. High rate of serious infection in juvenile idiopathic arthritis patients under biologic therapy in a real-life setting. MODERN RHEUMATOLOGY, v. 28, n. 2, p. 264-270, 2018. (14/14806-0, 15/03756-4)

TISEO, BRUNO CAMARGO; COCUZZA, MARCELLO; BONFA, ELOISA; SROUGI, MIGUEL; SILVA, CLOVIS A.. Male fertility potential alteration in rheumatic diseases: a systematic review. INTERNATIONAL BRAZ J UROL, v. 42, n. 1, p. 11-21, JAN-FEB 2016. (14/14806-0)

TISEO, B. C.; BONFA, E.; BORBA, E. F.; MUNHOZ, G. A.; WOOD, G. J. A.; SROUGI, M.; SILVA, C. A.; COCUZZA, M.. Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients. Lupus, v. 28, n. 1, p. 59-65, JAN 2019. (15/03756-4, 14/14806-0)

BRUNELLI, JULIANA BARBOSA; BONFIGLIOLI, KARINA ROSSI; SILVA, CLOVIS A.; KOZU, KATIA TOMIE; GOLDENSTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; AIKAWA, NADIA EMI. Rastreamento da infecção latente por tuberculose em pacientes com artrite idiopática juvenil previamente à terapia anti-TNF em um país de alto risco para tuberculose. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 57, n. 5, p. 392-396, SEP-OCT 2017. (14/14806-0)

LOURENCO, BENITO; KOZU, KATIA T.; LEAL, GABRIELA N.; SILVA, MARCO F.; FERNANDES, ELISABETH G. C.; FRANCA, CAMILA M. P.; SOUZA, FERNANDO H. C.; SILVA, CLOVIS A.. Contraception for adolescents with chronic rheumatic diseases. Revista Brasileira de Reumatologia, v. 57, n. 1, p. 73-81, JAN-FEB 2017. (14/14806-0, 11/12471-2)

PRISCILA ARAÚJO; MÁRCIO GUILHERME NUNES CARVALHO; MARLON VAN WEELDEN; BENITO LOURENÇO; LÍGIA BRUNI QUEIROZ; CLOVIS ARTUR SILVA. Uso indevido de drogas e função sexual em adolescentes com doenças crônicas. Revista Paulista de Pediatria, v. 34, n. 3, p. 323-329, 2016-09-00. (11/12471-2, 14/14806-0)

TOMIOKA, RENATO B.; FERREIRA, GABRIELA R. V.; AIKAWA, NADIA E.; MACIEL, GUSTAVO A. R.; SERAFINI, PAULO C.; SALLUM, ADRIANA M.; CAMPOS, LUCIA M. A.; GOLDESTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; SILVA, CLOVIS A.. Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients. CLINICAL RHEUMATOLOGY, v. 37, n. 10, p. 2869-2873, OCT 2018. (15/03756-4, 14/14806-0)