New functional aspects of eicosanoids

• Grant number: 14/07125-6
• Support Opportunities: Research Projects - Thematic Grants
• Start date: December 01, 2014
• End date: February 28, 2021
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Lúcia Helena Faccioli
• Grantee: Lúcia Helena Faccioli
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• Associated researchers: Carlos Arterio Sorgi ; Celio Lopes Silva ; Elaine Aparecida Del Bel Belluz Guimarães ; Eliane Candiani Arantes Braga ; Fabiani Gai Frantz ; Francisco Wanderley Garcia de Paula e Silva ; José Carlos Farias Alves Filho ; Luiz Alberto Beraldo de Moraes
• Associated research grant(s): 20/05207-6 - Prospective evaluation of lipid mediators production on the immune response against COVID-19: search for biomarkers and new therapeutic targets in the evolution of the disease, AP.R; 18/06230-1 - 6th Annual Meeting of the International Cytokine and Interferon Society, AR.EXT; 17/01765-1 - Cell Symposia: Cancer, Inflammation and Immunity, AR.EXT; 15/00658-1 - New functional aspects of eicosanoids, AP.EMU
• Associated scholarship(s): 18/25704-4 - Lipid analysis using ion mobility spectrometry (DMS) for determination of lipid profile in scorpions and snakes venom, BP.PD; 18/10929-0 - The role of CD14 receptor on the metabolic regulation of macrophages stimulated with the venom from Tityus serrulatus scorpion, BP.MS; 17/02314-3 - Investigation of cardiac changes that occur in poisoning by Tityus serrulatus scorpion venom, BP.DR; 16/22899-3 - Effect of the murine melanoma tumor microenvironment metabolites on macrophages lipid metabolism modulation., BP.IC; 16/16788-4 - Simultaneous identification and quantification of cytochrome-P450 pathway (CYP450)-derived eicosanoids using high performance liquid chromatography coupled to sequential mass spectrometry (HPLC-MS/MS), BP.PD

Abstract

In recent years new functions of EICs have been described, but much still needs to be researched on these lipids. This Thematic project aims to explore new aspects of EICs in six distinct and innovative subprojects. We will investigate the production and functions of EICs in five of them: (i) Investigation of the involvement of eicosanoids in chronic unpredictable stress-induced depression; (ii) Profile of macrophages, eicosanoid metabolism and tumor-associated activity; (iii) Relationship between activation of the inflammasome, production of lipid mediators, lung inflammation and death induced by scorpion venom; (iv) Involvement of aryl hydrocarbon receptor in the polarization of Treg, Th17 and Th22 cells and eicosanoids production in Histoplasma capsulatum infection; (v) Evaluation of the involvement of 5-lipoxygenase metabolites in Achromobacter xylosoxidans pulmonary infection. The last, (vi) Eicosanoid lipidomics from leukocytes of healthy individuals, aims to determine values of EICs production by leukocytes of healthy subjects for future comparison of production by patient's cells. This Thematic will be carried out by a multidisciplinary, multi-institutional and transnational team, with confirmed competency in different areas of the subproject, linked by a common topic, which is the study of new functional aspects of EICs. Moreover, we intend to establish a core reference for identification of EICs, by mass spectrometry. (AU)

Scientific publications

(47)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

ACUNHA, TANIZE; NARDINI, VIVIANI; FERRANTI PETI, ANA PAULA; BORGES PRADO, MORGANA KELLY; BERALDO MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. Targeted analysis of eicosanoids derived from cytochrome P450 pathway by high-resolution multiple-reaction monitoring mass spectrometry. Journal of Mass Spectrometry, v. 56, n. 7, JUL 2021. (16/16788-4, 15/00658-1, 14/07125-6, 18/25704-4)

ACUNHA, TANIZE; ROCHA, BRUNO ALVES; NARDINI, VIVIANI; BARBOSA JR, FERNANDO; FACCIOLI, LUCIA HELENA. Lipidomic profiling of the Brazilian yellow scorpion venom: new insights into inflammatory responses following Tityus serrulatus envenomation. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 86, n. 9, p. 13-pg., 2023-03-11. (15/00658-1, 21/03633-0, 18/24069-3, 14/07125-6, 22/07979-1, 18/25704-4)

PRADO, MORGANA K. B.; FONTANARI, CAROLINE; SOUZA, CAMILA O. S.; GARDINASSI, LUIZ G.; ZOCCAL, KARINA F.; DE PAULA-SILVA, FRANCISCO W. G.; PETI, ANA P. F.; SORGI, CARLOS A.; MEIRELLES, ALYNE F. G.; RAMOS, SIMONE G.; et al. IL-22 Promotes IFN-gamma-Mediated Immunity against Histoplasma capsulatum Infection. BIOMOLECULES, v. 10, n. 6, JUN 2020. (13/08216-2, 14/07125-6, 15/00658-1)

REIS, MOUZARLLEM B.; ELIAS-OLIVEIRA, JEFFERSON; PASTORE, MARCELLA R.; RAMOS, SIMONE G.; GARDINASSI, LUIZ G.; FACCIOLI, LUCIA H.. Interleukin-1 Receptor-Induced Nitric Oxide Production in the Pancreas Controls Hyperglycemia Caused by Scorpion Envenomation. TOXINS, v. 12, n. 3, MAR 2020. (17/02314-3, 14/07125-6)

DA COSTA, ADELIANE C.; DE RESENDE, DANILO P.; SANTOS, BRUNO DE P. O.; ZOCCAL, KARINA F.; FACCIOLI, LUCIA H.; KIPNIS, ANDRE; JUNQUEIRA-KIPNIS, ANA P.. Modulation of Macrophage Responses by CMX, a Fusion Protein Composed of Ag85c, MPT51, and HspX from Mycobacterium tuberculosis. FRONTIERS IN MICROBIOLOGY, v. 8, APR 12 2017. (14/07125-6)

DA SILVA-NETO, PEDRO, V; DO VALLE, VALERIA B.; FUZO, CARLOS A.; FERNANDES, TALITA M.; TORO, DIANA M.; FRAGA-SILVA, THAIS F. C.; BASILE, PATRICIA A.; DE CARVALHO, JONATAN C. S.; PIMENTEL, VINICIUS E.; PEREZ, MALENA M.; et al. Matrix Metalloproteinases on Severe COVID-19 Lung Disease Pathogenesis: Cooperative Actions of MMP-8/MMP-2 Axis on Immune Response through HLA-G Shedding and Oxidative Stress. BIOMOLECULES, v. 12, n. 5, p. 20-pg., 2022-05-01. (14/07125-6, 20/08534-8, 20/05270-0, 14/23946-0, 21/04590-3, 20/05207-6)

FRANCINE LORENCETTI-SILVA; MAYA FERNANDA MANFRIN ARNEZ; JOÃO PEDRO DE QUEIROZ THOMÉ; MARCIO SANTOS DE CARVALHO; FABRÍCIO KITAZONO DE CARVALHO; ALEXANDRA MUSSOLINO DE QUEIROZ; LÚCIA HELENA FACCIOLI; FRANCISCO WANDERLEY GARCIA PAULA-SILVA. Leukotriene B4 Loaded in Microspheres Inhibits Osteoclast Differentiation and Activation. Brazilian Dental Journal, v. 33, n. 5, p. 35-45, 2022-10-21. (14/07125-6)

GONCALVES, JULIANA DE LIMA; ALVES DUARTE, ANA CAROLINE; ALMEIDA-JUNIOR, LUCIANO APARECIDO; DE CARVALHO, FABRICIO KITAZONO; DE QUEIROZ, ALEXANDRA MUSSOLINO; MANFRIN ARNEZ, MAYA FERNANDA; FACCIOLI, LUCIA HELENA; GARCIA PAULA-SILVA, FRANCISCO WANDERLEY. Enamel biomineralization under the effects of indomethacin and celecoxib non-steroidal anti-inflammatory drugs. SCIENTIFIC REPORTS, v. 12, n. 1, p. 13-pg., 2022-09-22. (14/07125-6, 10/17611-4, 21/09272-0)

SOUZA, CAMILA OLIVEIRA SILVA; GARDINASSI, LUIZ GUSTAVO; RODRIGUES, VANDERLEI; FACCIOLI, LUCIA HELENA. Monocyte and Macrophage-Mediated Pathology and Protective Immunity During Schistosomiasis. FRONTIERS IN MICROBIOLOGY, v. 11, AUG 12 2020. (14/07125-6, 18/22667-0)

ACUNHA, TANIZE; NARDINI, VIVIANI; FACCIOLI, LUCIA HELENA. A lipidomics approach reveals new insights intoCrotalus durissus terrificusandBothrops moojenisnake venoms. ARCHIVES OF TOXICOLOGY, v. 95, n. 1, SEP 2020. (15/00658-1, 14/07125-6, 18/25704-4)

FUZO, CARLOS A.; FRAGA-SILVA, THAIS F. C.; MARUYAMA, SANDRA R.; BASTOS, VICTOR A. F.; ROGERIO, LUANA A.; TAKAMIYA, NAYORE T.; DA SILVA-NETO, PEDRO V.; PIMENTEL, VINICIUS E.; TORO, DIANA M.; PEREZ, MALENA M.; et al. The turning point of COVID-19 severity is associated with a unique circulating neutrophil gene signature. IMMUNOLOGY, v. 169, n. 3, p. 21-pg., 2023-03-08. (15/00658-1, 21/04590-3, 20/08534-8, 20/05207-6, 19/09881-6, 14/07125-6, 20/05270-0, 17/16328-6)

DE ARAUJO MOREIRA, MIRELLA DOS REIS; SALES-CAMPOS, HELIOSWILTON; FONTANARI, CAROLINE; GALVAO MEIRELES, ALYNE FAVERO; BORGES PRADO, MORGANA KELLY; ZOCCAL, KARINA FURLANI; SORGI, CARLOS ARTERIO; DA SILVA, CRISTIANE TEFE; GROPPO, MILTON; FACCIOLI, LUCIA HELENA. The ethanolic extract of Terminalia argentea Mart. & Zucc. bark reduces the inflammation through the modulation of cytokines and nitric oxide mediated by the downregulation of NF-κB. Journal of Ethnopharmacology, v. 261, p. 10-pg., 2020-10-28. (14/03332-7, 14/07125-6)

DOS REIS, MOUZARLLEM BARROS; FACCIOLI, LUCIA HELENA. CARDIAC DYSFUNCTION INDUCED BY SCORPION ENVENOMATION IS MEDIATED BY NLRP3-INDUCED ACUTE MYOCARDITIS. Toxicon, v. 168, p. 1-pg., 2019-10-05. (17/02314-3, 15/00658-1, 14/07125-6)

ZOCCAL, KARINA F.; GARDINASSI, LUIZ G.; BORDON, KARLA C. F.; ARANTES, ELIANE C.; MARLEAU, SYLVIE; ONG, HUY; FACCIOLI, LUCIA H.. EP80317 Restrains Inflammation and Mortality Caused by Scorpion Envenomation in Mice. FRONTIERS IN PHARMACOLOGY, v. 10, MAR 1 2019. (14/07125-6, 14/03332-7, 15/00658-1)

PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; PINHEIRO-JUNIOR, ERNESTO LOPES; ZOCCAL, KARINA FURLANI; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FERNANDA GOBBI; PEIGNEUR, STEVE; VRIENS, KIM; THEVISSEN, KARIN; ANGELO CAMMUE, BRUNO PHILIPPE; et al. Non-disulfide-bridged peptides from Tityus serrulatus venom: Evidence for proline-free ACE-inhibitors. Peptides, v. 82, p. 44-51, AUG 2016. (13/21342-7, 14/03332-7, 12/13590-8, 13/06380-0, 14/07125-6, 13/21329-0, 11/12317-3)

DOS SANTOS, RAFAELA SILVA; SORGI, CARLOS ARTERIO; FERRANTI PETI, ANA PAULA; VERAS, FLAVIO PROTASIO; FACCIOLI, LUCIA HELENA; GALDINO, GIOVANE. Involvement of Spinal Cannabinoid CB2 Receptors in Exercise-Induced Antinociception. Neuroscience, v. 418, p. 177-188, OCT 15 2019. (14/07125-6, 15/00658-1)

SOUZA, CAMILA O. S.; ESPINDOLA, MILENA S.; FONTANARI, CAROLINE; PRADO, MORGANA K. B.; FRANTZ, FABIANI G.; RODRIGUES, VANDERLEI; GARDINASSI, LUIZ G.; FACCIOLI, LUCIA H.. CD18 Regulates Monocyte Hematopoiesis and Promotes Resistance to Experimental Schistosomiasis. FRONTIERS IN IMMUNOLOGY, v. 9, AUG 31 2018. (14/07125-6, 15/00658-1)

ZOCCAL, KARINA F.; SORGI, CARLOS A.; HORI, JULIANA I.; PAULA-SILVA, FRANCISCO W. G.; ARANTES, ELIANE C.; SEREZANI, CARLOS H.; ZAMBONI, DARIO S.; FACCIOLI, LUCIA H.. Opposing roles of LTB4 and PGE(2) in regulating the inflammasome-dependent scorpion venom-induced mortality. NATURE COMMUNICATIONS, v. 7, FEB 2016. (14/07125-6, 11/51023-5, 14/03332-7, 14/04684-4)

FERRANTI PETI, ANA PAULA; LOCACHEVIC, GISELE APARECIDA; BORGES PRADO, MORGANA KELLY; BERALDO DE MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. High-resolution multiple reaction monitoring method for quantification of steroidal hormones in plasma. Journal of Mass Spectrometry, v. 53, n. 5, p. 423-431, MAY 2018. (14/07125-6, 16/16788-4, 15/00658-1)

REIS, MOUZARLLEM BARROS; ZOCCAL, KARINA FURLANI; GARDINASSI, LUIZ GUSTAVO; FACCIOLI, LUCIA HELENA. Scorpion envenomation and inflammation: Beyond neurotoxic effects. Toxicon, v. 167, p. 174-179, SEP 2019. (17/02314-3, 14/07125-6)

PEREIRA, PRISCILLA A. T.; ASSIS, PATRICIA A.; PRADO, MORGANA K. B.; RAMOS, SIMONE G.; ARONOFF, DAVID M.; DE PAULA-SILVA, FRANCISCO W. G.; SORGI, CARLOS A.; FACCIOLI, LUCIA H.. Prostaglandins D-2 and E-2 have opposite effects on alveolar macrophages infected with Histoplasma capsulatum. Journal of Lipid Research, v. 59, n. 2, p. 195-206, FEB 2018. (09/07169-5, 14/07125-6)

LOUREIRO, LUMA DA COSTA; LOUREIRO, LUANA DA COSTA; GABRIEL-JUNIOR, EDSON ALVES; ZAMBUZI, FABIANA ALBANI; FONTANARI, CAROLINE; SALES-CAMPOS, HELIOSWILTON; FRANTZ, FABIANI GAI; FACCIOLI, LUCIA HELENA; SORGI, CARLOS ARTERIO. Pulmonary surfactant phosphatidylcholines induce immunological adaptation of alveolar macrophages. Molecular Immunology, v. 122, p. 163-172, JUN 2020. (18/15066-0, 14/07125-6, 15/00658-1)

BERNARDI, DANIELA S.; BITENCOURT, CLAUDIA; DA SILVEIRA, DENISE S. C.; DA CRUZ, ESTAEL L. C. M.; PEREIRA-DA-SILVA, MARCELO A.; FACCIOLI, LUCIA HELENA; LOPEZ, RENATA F. V.. Effective transcutaneous immunization using a combination of iontophoresis and nanoparticles. Nanomedicine-Nanotechnology Biology and Medicine, v. 12, n. 8, p. 2439-2448, NOV 2016. (12/05177-3, 14/07125-6, 11/13307-1, 14/22451-7)

ELIAS-OLIVEIRA, JEFFERSON; BORGES PRADO, MORGANA KELLY; SILVA SOUZA, CAMILA OLIVEIRA; PASTORE, MARCELLA ROVERATO; RAMOS, SIMONE GUSMAO; COSTA DARINI, ANA LUCIA; GARDINASSI, LUIZ GUSTAVO; FACCIOLI, LUCIA HELENA. CD14 signaling mediates lung immunopathology and mice mortality induced by Achromobacter xylosoxidans. Inflammation Research, v. 71, n. 12, p. 12-pg., 2022-10-25. (14/07125-6)

LORENCETTI-SILVA, FRANCINE; SALES, LARISSA STHEFANI; LAMARQUE, GIULIANA DE CAMPOS CHAVES; CAIXETA, GIOVANA AMORIM; ARNEZ, MAYA FERNANDA MANFRIN; FACCIOLI, LUCIA HELENA; PAULA-SILVA, FRANCISCO WANDERLEY GARCIA. Effects of inflammation in dental pulp cell differentiation and reparative response. FRONTIERS IN DENTAL MEDICINE, v. 3, p. 8-pg., 2022-08-02. (14/07125-6, 19/00204-1)

PEREIRA, PRISCILLA A. T.; BITENCOURT, CLAUDIA S.; REIS, MOUZARLLEM B.; FRANTZ, FABIANI G.; SORGI, CARLOS A.; SOUZA, CAMILA O. S.; SILVA, CELIO L.; GARDINASSI, LUIZ G.; FACCIOLI, LUCIA H.. Immunomodulatory activity of hyaluronidase is associated with metabolic adaptations during acute inflammation. Inflammation Research, v. 69, n. 1, NOV 2019. (07/04741-4, 14/07125-6, 09/07169-5, 15/00658-1)

SORGI, CARLOS ARTERIO; FERRANTI PETI, ANA PAULA; PETTA, TANIA; GALVAO MEIRELLES, ALYNE FAVERO; FONTANARI, CAROLINE; BERALDO DE MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays. SCIENTIFIC DATA, v. 5, AUG 21 2018. (14/07125-6, 16/16788-4, 15/00658-1)

PETEAN, IGOR BASSI FERREIRA; SILVA-SOUSA, ALICE CORREA; DA SILVA, RAQUEL ASSED BEZERRA; LUCISANO, MARILIA PACIFICO; DA SILVA, LEA ASSED BEZERRA; DE CASTRO, GUILHERME PIEDADE ASSED; SOUSA-NETO, MANOEL DAMIAO; FACCIOLI, LUCIA HELENA; PAULA-SILVA, FRANCISCO WANDERLEY GARCIA. Systemic inhibition of 5-lipoxygenase by MK-886 exacerbates apical periodontitis bone loss in a mouse model. BMC ORAL HEALTH, v. 23, n. 1, p. 9-pg., 2023-01-10. (14/07125-6, 10/17611-4, 13/09595-7)

DE CARVALHO, JONATAN C. S.; DA SILVA-NETO, PEDRO V.; TORO, DIANA M.; FUZO, CARLOS A.; NARDINI, VIVIANI; PIMENTEL, VINICIUS E.; PEREZ, MALENA M.; FRAGA-SILVA, THAIS F. C.; OLIVEIRA, CAMILLA N. S.; DEGIOVANI, AUGUSTO M.; et al. The Interplay among Glucocorticoid Therapy, Platelet-Activating Factor and Endocannabinoid Release Influences the Inflammatory Response to COVID-19. Viruses-Basel, v. 15, n. 2, p. 22-pg., 2023-02-01. (15/00658-1, 21/04590-3, 20/08534-8, 20/05207-6, 14/07125-6, 22/07287-2, 20/05270-0)

DE MACEDO, LUANA HENRIQUE; SOUZA, CAMILA OLIVEIRA SILVA; GARDINASSI, LUIZ GUSTAVO; FACCIOLI, LUCIA HELENA. CD14 regulates the metabolomic profiles of distinct macrophage subsets under steady and activated states. Immunobiology, v. 227, n. 2, p. 10-pg., 2022-02-19. (14/07125-6, 18/10929-0, 15/00658-1, 18/22667-0)

SOUZA, CAMILA O. S.; ELIAS-OLIVEIRA, JEFFERSON; PASTORE, MARCELLA R. R.; FONTANARI, CAROLINE; RODRIGUES, VANESSA F. F.; RODRIGUEZ, VANDERLEI; GARDINASSI, LUIZ G. G.; FACCIOLI, LUCIA H.. CD18 controls the development and activation of monocyte-to-macrophage axis during chronic schistosomiasis. FRONTIERS IN IMMUNOLOGY, v. 13, p. 13-pg., 2022-10-03. (14/07125-6, 18/22667-0)

LOCACHEVIC, GISELE A.; PRADO, MORGANA K. B.; ZOCCAL, KARINA F.; PEREIRA, PRISCILLA A. T.; SORGI, CARLOS A.; BORTOLANZA, MARIZA; PETI, ANA PAULA F.; FOGACA, MANOELA V.; GUIMARAES, FRANCISCO S.; DEL BEL, ELAINE; et al. Paradoxical Effect of LTB4 on the Regulation of Stress-Induced Corticosterone Production. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 13, APR 16 2019. (14/07125-6, 15/00658-1)

TORO, DIANA MOTA V.; DA SILVA-NETO, PEDRO V.; DE CARVALHO, JONATAN C. S. A.; FUZO, CARLOS A. M.; PEREZ, MALENA M.; PIMENTEL, VINICIUS E.; FRAGA-SILVA, THAIS F. C.; OLIVEIRA, CAMILLA N. S. R.; CARUSO, GLAUCIA R.; VILELA, ADRIANA F. L.; et al. Plasma Sphingomyelin Disturbances: Unveiling Its Dual Role as a Crucial Immunopathological Factor and a Severity Prognostic Biomarker in COVID-19. CELLS, v. 12, n. 15, p. 23-pg., 2023-08-01. (20/08534-8, 15/00658-1, 20/05270-0, 20/05207-6, 21/04590-3, 14/07125-6)

REIS, MOUZARLLEM BARROS; RAMOS, SIMONE GUSMAO; ROCHA, LENALDO BRANCO; FACCIOLI, LUCIA HELENA. Mitochondrial swelling in cardiomyocytes: Insights from a murine model of Tityus serrulatus scorpion envenomation. Toxicon, v. 233, p. 4-pg., 2023-08-18. (14/07125-6, 17/02314-3)

ZOCCAL, KARINA F.; FERREIRA, GIOVANA Z.; PRADO, MORGANA K. B.; GARDINASSI, LUIZ G.; SAMPAIO, V, SUELY; FACCIOLI, LUCIA H.. LTB4 and PGE(2) modulate the release of MIP-1 alpha and IL-1 beta by cells stimulated with Bothrops snake venoms. Toxicon, v. 150, p. 289-296, AUG 2018. (14/07125-6, 14/03332-7)

CERNI, FELIPE AUGUSTO; PUCCA, MANUELA BERTO; ZOCCAL, KARINA FURLANI; FRANTZ, FABIANI GAI; FACCIOLI, LUCIA HELENA; ARANTES, ELIANE CANDIANI. Expanding biological activities of Ts19 Frag-II toxin: Insights into IL-17 production. Toxicon, v. 134, p. 18-25, AUG 2017. (14/07125-6, 13/21329-0, 14/03332-7, 13/21342-7)

REIS, MOUZARLLEM BARROS; TARTARI PEREIRA, PRISCILLA APARECIDA; CAETANO, GUILHERME FERREIRA; LEITE, MARCEL NANI; GALVAO, ALYNE FAVERO; GARCIA PAULA-SILVA, FRANCISCO WANDERLEY; CIPRIANI FRADE, MARCO ANDREY; FACCIOLI, LUCIA HELENA. Lipoxin A(4) encapsulated in PLGA microparticles accelerates wound healing of skin ulcers. PLoS One, v. 12, n. 7, JUL 28 2017. (14/07125-6)

PRADO, MORGANA K. B.; LOCACHEVIC, GISELE A.; ZOCCAL, KARINA F.; PAULA-SILVA, FRANCISCO W. G.; FONTANARI, CAROLINE; FERREIRA, JOSEANE C.; PEREIRA, PRISCILLA A. T.; GARDINASSI, LUIZ G.; RAMOS, SIMONE G.; SORGI, CARLOS A.; et al. Leukotriene B-4 is essential for lung host defence and alpha-defensin-1 production during Achromobacter xylosoxidans infection. SCIENTIFIC REPORTS, v. 7, DEC 15 2017. (14/07125-6)

ZOCCAL, KARINA F.; GARDINASSI, LUIZ G.; SORGI, CARLOS A.; MEIRELLES, ALYNE F. G.; BORDON, KARLA C. F.; GLEZER, ISAIAS; CUPO, PALMIRA; MATSUNO, ALESSANDRA K.; BOLLELA, VALDES R.; ARANTES, ELIANE C.; et al. CD36 Shunts Eicosanoid Metabolism to Repress CD14 Licensed Interleukin-1 beta Release and Inflammation. FRONTIERS IN IMMUNOLOGY, v. 9, APR 27 2018. (13/07937-8, 14/07125-6, 15/00658-1, 14/03332-7)

SORGI, CARLOS A.; ZARINI, SIMONA; MARTIN, SARAH A.; SANCHEZ, RAPHAEL L.; SCANDIUZZI, RODRIGO F.; GIJON, MIGUEL A.; GUIJAS, CARLOS; FLAMAND, NICOLAS; MURPHY, ROBERT C.; FACCIOLI, LUCIA H.. Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid. SCIENTIFIC REPORTS, v. 7, SEP 8 2017. (14/07125-6, 14/13127-1, 15/00658-1)

GALVAO, ALYNE FAVERO; PETTA, TANIA; FLAMAND, NICOLAS; BOLLELA, VALDES ROBERTO; SILVA, CELIO LOPES; JARDULI, LUCIANA RIBEIRO; RIBEIRO MALMEGRIM, KELEN CRISTINA; SIMOES, BELINDA PINTO; BERALDO DE MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. Plasma eicosanoid profiles determined by high-performance liquid chromatography coupled with tandem mass spectrometry in stimulated peripheral blood from healthy individuals and sickle cell anemia patients in treatment. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 408, n. 13, p. 3613-3623, MAY 2016. (14/07125-6)

SANTOS-LOBATO, BRUNO L.; GARDINASSI, LUIZ GUSTAVO; BORTOLANZA, MARIZA; PETI, ANA PAULA FERRANTI; PIMENTEL, ANGELA V.; FACCIOLI, LUCIA HELENA; DEL-BEL, ELAINE A.; TUMAS, VITOR. etabolic Profile in Plasma AND CSF of LEVODOPA-induced Dyskinesia in Parkinson's Disease: Focus on Neuroinflammatio. Molecular Neurobiology, v. 59, n. 2, DEC 2021. (14/07125-6, 12/17626-7)

DE ARAUJO MOREIRA, MIRELLA DOS REIS; SALES-CAMPOS, HELIOSWILTON; FONTANARI, CAROLINE; GALVAO MEIRELES, ALYNE FAVERO; BORGES PRADO, MORGANA KELLY; ZOCCAL, KARINA FURLANI; SORGI, CARLOS ARTERIO; DA SILVA, CRISTIANE TEFE; GROPPO, MILTON; FACCIOLI, LUCIA HELENA. The ethanolic extract of Terminalia argentea Mart. & Zucc. bark reduces the inflammation through the modulation of cytokines and nitric oxide mediated by the downregulation of NF-kappa B. Journal of Ethnopharmacology, v. 261, OCT 28 2020. (14/03332-7, 14/07125-6)

REIS, MOUZARLLEM B.; RODRIGUES, FERNANDA L.; LAUTHERBACH, NATALIA; KANASHIRO, ALEXANDRE; SORGI, CARLOS A.; MEIRELLES, ALYNE F. G.; SILVA, CARLOS A. A.; ZOCCAL, KARINA F.; SOUZA, CAMILA O. S.; RAMOS, SIMONE G.; et al. Interleukin-1 receptor-induced PGE(2) production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation. NATURE COMMUNICATIONS, v. 11, n. 1, OCT 28 2020. (15/21976-1, 14/07125-6, 17/02314-3, 15/00658-1)

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