Comparison of conventional and BontA treatments in patients with myogenic temporomandibular disorders and chronic pain

• Grant number: 14/15863-7
• Support Opportunities: Regular Research Grants
• Duration: January 01, 2015 - December 31, 2016
• Field of knowledge: Health Sciences - Dentistry - Dental Clinics
• Principal Investigator: Celia Marisa Rizzatti Barbosa
• Grantee: Celia Marisa Rizzatti Barbosa
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

The purpose of this blinded, randomized and controlled trial is to compare the effectiveness of BoNTA (treated groups) using three dosages (30U of BoNTA in masseter muscles and 10U of BoNTA in anterior temporal / 50U of BoNTA in muscles masseter and 20U of BoNTA in anterior temporal / 70U of BoNTA in masseter / 25 of BoNTA in anterior temporal) in chronic pain TMD, when compared to occlusal splint (positive control group) or 0.9% saline solution at the same site of BoNTA puction (negative control group). One hundred volunteers classified by RDC / TMD - GI muscle will participate and randomly divided into five groups (n = 20): positive control group will be treated with counseling and occlusal splint, negative control group will be treated with counseling and saline applications, and the treated groups that will receive counseling and BoNTA in different dosages. The dependent variables will be subjective measurement of pain intensity by Visual Analogue Scale (VAS), objective analysis of the pressure pain threshold by algometry, and electromyographic evaluation of masseter and anterior temporal muscles. It will be made before, during and after interventions (7, 14, 21, 28, 90, and 180 days after application of the treatments). Proper statistical tools will be used for data analysis, considering 5% significance are used. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CANALES, GIANCARLO DE LA TORRE; ALVAREZ-PINZON, NATALIA; MANUEL MUNOZ-LORA, VICTOR RICARDO; PERONI, LEONARDO VIEIRA; GOMES, AMANDA FARIAS; SANCHEZ-AYALA, ALFONSO; HAITER-NETO, FRANCISCO; MANFREDINI, DANIELE; RIZZATTI-BARBOSA, CELIA MARISA. Efficacy and Safety of Botulinum Toxin Type A on Persistent Myofascial Pain: A Randomized Clinical Trial. TOXINS, v. 12, n. 6, JUN 2020. (14/15863-7)

CANALES, GIANCARLO DE LA TORRE; CAMARA-SOUZA, MARIANA BARBOSA; POLUHA, RODRIGO LORENZI; GRILLO, CASSIA MARIA; RODRIGUES CONTI, PAULO CESAR; ROSARIO DE SOUSA, MARIA DA LUZ; MATHEUS RODRIGUES GARCIA, RENATA CUNHA; RIZZATTI-BARBOSA, CELIA MARISA. Botulinum toxin type A and acupuncture for masticatory myofascial pain: a randomized clinical trial. Journal of Applied Oral Science, v. 29, 2021. (14/15863-7, 17/21674-0, 17/23429-3)

MANUEL MUNOZ LORA, VICTOR RICARDO; CLEMENTE-NAPIMOGA, JULIANA TRINDADE; ABDALLA, HENRIQUE BALLASSINI; MACEDO, CRISTINA GOMES; CANALES, GIANCARLO DE LA TORRE; RIZZATTI BARBOSA, CELIA MARISA. Botulinum toxin type A reduces inflammatory hypernociception induced by arthritis in the temporomadibular joint of rats. Toxicon, v. 129, p. 52-57, APR 2017. (14/15863-7)

CANALES, GIANCARLO DE LA TORRE; POLUHA, RODRIGO LORENZI; ALVAREZ PINZON, NATALIA; DA SILVA, BRUNO RODRIGUES; ALMEIDA, ANDRE MARIZ; ERNBERG, MALIN; MANSO, ANA CRISTINA; BONJARDIM, LEONARDO RIGOLDI; RIZZATTI-BARBOSA, CELIA MARISA. Efficacy of Botulinum Toxin Type-A I in the Improvement of Mandibular Motion and Muscle Sensibility in Myofascial Pain TMD Subjects: A Randomized Controlled Trial. TOXINS, v. 14, n. 7, p. 9-pg., 2022-07-01. (14/15863-7)

CANALES, GIANCARLO DE LA TORRE; POLUHA, RODRIGO LORENZI; ALVAREZ PINZON, YEIDI NATALIA; RODRIGUES CONTI, PAULO CESAR; MANFREDINI, DANIELE; SANCHEZ-AYALA, ALFONSO; RIZZATTI-BARBOSA, CELIA MARISA. ffects of Botulinum Toxin Type A on the Psychosocial Features of Myofascial Pain TMD Subjects: A Randomized Controlled Tria. JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE, v. 35, n. 4, p. 288-296, FAL 2021. (14/15863-7)