The role of vitamin D on cardiometabolic and immuno-inflammatory profile of postmenopausal women

• Grant number: 14/19382-3
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2015
• End date: July 31, 2017
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Eliana Aguiar Petri Nahás
• Grantee: Eliana Aguiar Petri Nahás
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Gilberto Uemura ; Jorge Nahas Neto ; Maria Terezinha Serrão Peraçoli

Abstract

Deficiency of vitamin D (VD) and the increase in the prevalence of obesity are considered important public health issues. Recent evidence suggests the involvement of the VD in several chronic diseases: obesity, hypertension, diabetes, metabolic syndrome, and consequently the cardiovascular disease (CVD). The important role played by VD on bone mass is well defined, however extra-osseous effects of VD on cardiometabolic markers and immuno-inflammatory drugs are under current investigation. In recent years the associations between VD deficiency, inflammation and cardio-metabolic disease have been proposed. However the information on the association between VD and inflammatory markers in the general population is scarce. And there are few studies directed to postmenopausal women, an important risk group for CVD. If there is a relationship between serum values of VD and cardiometabolic and immuno-inflammatory profile, our hypothesis is that the isolated supplementation of VD could provide significant reduction in markers of cardiovascular risk. Clinical research is important to improve the quality of life of postmenopausal women and reduce health care costs. It is expected that with the study of association between isolated supplementation of vitamin D and indicators of cardiovascular disease in postmenopausal women can identify the effects of Vitamin D supplementation on cardiometabolic and immune-inflammatory profile of cardiovascular disease in postmenopausal women,affecting considerably the morbidity and the quality of life of patients followed at the Climacteric and Menopause Clinic of the Botucatu Medical School, UNESP. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BUELONI-DIAS, FLAVIA NEVES; ORSATTI, CLAUDIO LERA; CANGUSSU, LUCIANA MENDES; POLONI, PRISCILA FERREIRA; SPADOTO-DIAS, DANIEL; NAHAS-NETO, JORGE; NAHAS, ELIANA A. P.. Isolated vitamin D supplementation improves the immune-inflammatory biomarkers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, v. 25, n. 8, p. 897-903, AUG 2018. (14/19382-3)

ALMEIDA-FILHO, BENEDITO DE SOUSA; VESPOLI, HELOISA DE LUCA; PESSOA, EDUARDO CARVALHO; MACHADO, MURILO; NAHAS-NETO, JORGE; PETRI NAHAS, ELIANA AGUIAR. Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, v. 174, p. 284-289, NOV 2017. (14/19382-3)

SCHMITT, ENEIDA BOTEON; NAHAS-NETO, JORGE; BUELONI-DIAS, FLAVIA; POLONI, PRISCILA FERREIRA; ORSATTI, CLAUDIO LERA; PETRI NAHAS, ELIANA AGUIAR. Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women. MATURITAS, v. 107, p. 97-102, JAN 2018. (14/19382-3)

ORSATTI, CLAUDIO LERA; ORSATTI, FABIO LERA; BEZERRA, THAIZ GEOVANA; QUEVEDO, ANA; NAHAS, ELIANA AGUIAR PETRI. Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome. Gynecological Endocrinology, v. 38, n. 9, p. 6-pg., 2022-07-26. (14/19382-3)

ORSATTI, CLAUDIO LERA; ORSATTI, FABIO LERA; DE SOUZA, JOAO PEDRO ESTEVES ALVES; NAHAS, ELIANA AGUIAR PETRI. Impact of vitamin D supplementation on modulating heat-shock proteins in postmenopausal women: a randomized, double-blind, placebo-controlled study. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, v. 30, n. 7, p. 8-pg., 2023-07-01. (14/19382-3)

SCHMITT, ENEIDA B.; ORSATTI, CLAUDIO L.; CANGUSSU, LUCIANA; BUELONI-DIAS, FLAVIA N.; POLONI, PRISCILA F.; SPADOTO-DIAS, DANIEL; NAHAS, ELIANA A. P.. Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trial. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, v. 30, n. 1, p. 7-pg., 2023-01-01. (14/19382-3)

FERREIRA, P. P.; CANGUSSU, L.; BUELONI-DIAS, F. N.; ORSATTI, C. L.; SCHMITT, E. B.; NAHAS-NETO, J.; NAHAS, E. A. P.. Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women. CLIMACTERIC, v. 23, n. 1, MAY 2019. (14/19382-3)