Immunogenetic markers for gestational Diabetes mellitus

• Grant number: 14/18730-8
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2014
• End date: November 30, 2016
• Field of knowledge: Biological Sciences - Immunology - Immunogenetics
• Principal Investigator: Eduardo Antônio Donadi
• Grantee: Eduardo Antônio Donadi
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Celso Teixeira Mendes Junior ; Erick da Cruz Castelli

Abstract

It has been estimated that until 2030 more than 400 million people will develop diabetes. A variety of diabetes mellitus types has been described, including the type 1 multigenic (DM-1), of autoimmune origin or idiopathic, the monogenic, the gestational (GDM) and the type 2 (DM-2). The gestational diabetes mellitus is the most common disturb during pregnancy. The standard definition of GDM is the abnormal glucose metabolism diagnosed for the first time during pregnancy. Women with GDM history usually present postpartum diabetes, resistance to insulin, metabolic syndrome, hipertension and dislipidemy. The early detection of this metabolic condition may allow a previous intervention to prevent or even delay other types of diabetes. Some studies in women with GDM have pointed out the induction of genes involved in the immune response, particularly those associated with inflamation. In this context, our project aims to detect polymorphisms and haplotypes of the class I HLA genes (considering all segments - promotor, coding and 3'UTR) associated with susceptibility to GDM and to computationally evaluate the subjacent mechanisms to these associations. Also, this project aims to detect microRNAs diferentially expressed that might be markers for GDM, besides the construction of interaction nets of microRNAs and messenger RNAs of genes involved with GDM. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASTELLI, ERICK C.; GERASIMOU, PETROULA; PAZ, MICHELLE A.; RAMALHO, JAQUELINE; PORTO, IANE O. P.; LIMA, THALITTA H. A.; SOUZA, ANDREIA S.; VEIGA-CASTELLI, LUCIANA C.; COLLARES, CRISTHIANNA V. A.; DONADI, EDUARDO A.; et al. HLA-G variability and haplotypes detected by massively parallel sequencing procedures in the geographicaly distinct population samples of Brazil and Cyprus. Molecular Immunology, v. 83, p. 115-126, MAR 2017. (13/17084-2, 14/18730-8)

RAMALHO, JAQUELINE; VEIGA-CASTELLI, LUCIANA C.; DONADI, EDUARDO A.; MENDES-JUNIOR, CELSO T.; CASTELLI, ERICK C.. HLA-E regulatory and coding region variability and haplotypes in a Brazilian population sample. Molecular Immunology, v. 91, p. 173-184, NOV 2017. (13/17084-2, 14/18730-8)