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The role of AMH signaling on medaka sex differentiation and gametogenesis

Grant number: 14/50602-0
Support type:Regular Research Grants
Duration: December 01, 2014 - November 30, 2016
Field of knowledge:Biological Sciences - Morphology
Cooperation agreement: BAYLAT/StMBW - Bavarian Academic Center for Latin America and Bavarian State Ministry of Science and the Arts
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Rafael Henrique Nóbrega
Grantee:Rafael Henrique Nóbrega
Principal investigator abroad: Manfred Scharlt
Institution abroad: Universität Würzburg, Germany
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated research grant:12/00423-6 - Paracrine and molecular regulation of the spermatogonial stem cell niche in zebrafish (Danio rerio) and the use of common carp (Cyprinus carpio) as a model to delay spermatogonial differentiation during puberty, AP.R

Abstract

Amh signaling is an important effector in the decision whether the bipotencial gonad anlage will become a testis or ovary. Studies with medaka hotei, where Amh type II receptor (Amhr2) is mutated showed an overproliferation of germ cells and a male-to-female sex reversal. Our hypothesis is that Amh regulates germ cell number, which may nfluence the sex differentiation decision in medaka. Moreover, Amh might have a role in adult gametogenesis. Therefore, we aimed to evaluate Amh signaling during sex differentiation and gametogenesis. For that transgenic lines overexpressing amhr2 or lacking amh/amhr2 will be generated in medaka. Genetic screening for Y chromosome contrasted with gonad histology will be performed to evaluate sex reversal. Moreover, number of germ cells, proliferation and steroid release will be conducted in each transgenic line to unravel the role of Amh signaling in medaka gametogenesis. All these data will provide evidences to better understand the role of Amh as an important effector in the control of germ cell number, which might influences the sex differentiation decision and gametogenesis in medaka. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Articles published in other media outlets (28 total):
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Descubren genes relacionados con la diferenciación sexual en un pez amazónico gigante 
Descubren genes relacionados con la diferenciación sexual en un pez amazónico gigante 
Descubren genes relacionados con la diferenciación sexual en un pez amazónico gigante 
Descubren genes relacionados con la diferenciación sexual en un pez amazónico gigante 
Descubren genes relacionados con la diferenciación sexual en un pez amazónico gigante 
Descubren genes relacionados con la diferenciación sexual en un pez amazónico gigante 
Researchers Identify Genes Linked To Sex Differentiation In Giant Amazon Fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers ID genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Researchers identify genes linked to sex differentiation in giant Amazon fish 
Identificados genes ligados à diferenciação sexual em pirarucus 
Unesp de Botucatu identifica genes ligados à diferenciação sexual em pirarucus 
Identificados genes ligados à diferenciação sexual em pirarucus 
Identificados genes ligados à diferenciação sexual em pirarucus 
Pirarucu – Identificados genes ligados à diferenciação sexual da espécie 
Diferenciação sexual em pirarucus é encontrada em genes 
Ciência: identificados genes ligados à diferenciação sexual em pirarucus 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DU, KANG; WUERTZ, SVEN; ADOLFI, MATEUS; KNEITZ, SUSANNE; STOECK, MATTHIAS; OLIVEIRA, MARCOS; NOBREGA, RAFAEL; ORMANNS, JENNY; KLOAS, WERNER; FERON, ROMAIN; KLOPP, CHRISTOPHE; PARRINELLO, HUGUES; JOURNOT, LAURENT; HE, SHUNPING; POSTLETHWAIT, JOHN; MEYER, AXEL; GUIGUEN, YANN; SCHARTL, MANFRED. The genome of the arapaima (Arapaima gigas) provides insights into gigantism, fast growth and chromosomal sex determination. SCIENTIFIC REPORTS, v. 9, MAR 28 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.