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Immobilization of metal nanoparticules in ultrathin films aiming biosensing


This project aims to immobilization of gold metal nanoparticles into nanostructured films obtained by Langmuir-Blodgett (LB) and layer by layer techniques (LbL) for detection of several analytes by electrochemical techniques. The sensor units are composed using ultrathin films of metal nanoparticles with the enzyme deposited onto solid substrates. The flexibility of controlling the thickness of the films offered by these techniques can be exploited to achieve low response time of the sensor units. These units will be immersed in liquid systems and the acquisition and characterization of results will be carried out by electrochemical measurements. Mixed films of nanoparticles and GOx as well as their interaction with analytes, will be studied with spectroscopic techniques such as absorption in the UV-Vis, FTIR and Raman and electrochemical (cyclic voltammetry and amperometry). The films will also be characterized by surface plasmon resonance (SPR) allows to determine its thickness and investigate molecular interactions between the material and the analyte. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIYAZAKI, CELINA MASSUMI; SHIMIZU, FLAVIO MAKOTO; MEJIA-SALAZAR, J. R.; OLIVEIRA, JR., OSVALDO N.; FERREIRA, MARYSTELA. Surface plasmon resonance biosensor for enzymatic detection of small analytes. Nanotechnology, v. 28, n. 14, . (13/14262-7, 16/12311-9, 14/15093-7, 12/15543-7, 14/17519-1)
TAVARES MASCAGNI, DANIELA BRANCO; MIYAZAKI, CELINA MASSUMI; DA CRUZ, NILSON CRISTINO; DE MORAES, MARLI LEITE; RIUL, JR., ANTONIO; FERREIRA, MARYSTELA. Layer-by-layer assembly of functionalized reduced graphene oxide for direct electrochemistry and glucose detection. Materials Science & Engineering C-Materials for Biological Applications, v. 68, p. 739-745, . (14/15093-7, 14/17519-1)
GRACA, JULIANA SANTOS; MIYAZAKI, CELINA MASSUMI; SHIMIZU, FLAVIO MAKOTO; VOLPATI, DIOGO; MEJIA-SALAZAR, J. R.; OLIVEIRA, JR., OSVALDO N.; FERREIRA, MARYSTELA. On the importance of controlling film architecture in detecting prostate specific antigen. Applied Surface Science, v. 434, p. 1175-1182, . (13/14262-7, 14/17519-1, 14/15093-7, 13/23288-0, 12/15543-7, 16/12311-9)
MIYAZAKI, CELINA MASSUMI; PEREIRA, TAMYRIS PASCHOAL; TAVARES MASCAGNI, DANIELA BRANCO; DE MORAES, MARLI LEITE; FERREIRA, MARYSTELA. Monoamine oxidase B layer-by-layer film fabrication and characterization toward dopamine detection. Materials Science & Engineering C-Materials for Biological Applications, v. 58, p. 310-315, . (14/17519-1, 14/15093-7)
SILVA, DAIANE P. B.; MIYAZAKI, CELINA M.; MASCAGNI, DANIELA B. T.; FERREIRA, MARYSTELA. Layer-by-Layer Films of Gold Nanoparticles and Carbon Nanotubes for Improved Amperometric Detection of Cholesterol. Journal of Nanoscience and Nanotechnology, v. 19, n. 9, p. 5483-5488, . (14/17519-1)

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