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Study of viruses transmitted by rodents and arthropods: diagnosis and cross-protection


Among the viruses affecting tropical countries, those transmitted by rodents (robovirus, rodent-borne virus) and arthropods (arbovirus, arthropod-borne virus) have great importance in public health and in veterinary because most of them are zoonoses. Several of them are emergent viruses, representing threats to public health worldwide. Arboviruses and roboviruses causing diseases in humans in Brazil belong mainly to four families: Flaviviridae, Togaviridae, Bunyaviridae, and Arenaviridae. Considering the importance in public health of some of these viruses, and the possibility of emergence of others, it is of great interest the study of several aspects of these viruses. Therefore, the aim of this project is to study different aspects related to arboviruses and roboviruses such diagnosis and crossprotection. In diagnosis, we will evaluate the usefulness of a DNA microarray platform for the detection of arboviruses and roboviruses circulating in an endemic area for malaria; we will develop a real-time RT-PCR for type specific detection of dengue virus (DENV) and a biosensor for detection of DENV NS1 protein in saliva. The cross-protecion induced by member of the genus Flavivirus against Rocio virus and that observed for the four DENV serotypes will be also studied. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AMARILLA, ALBERTO ANASTACIO; FUMAGALLI, MARCILIO JORGE; FIGUEIREDO, MARIO LUIS; LIMA-JUNIOR, DJALMA S.; SANTOS-JUNIOR, NILTON NASCIMENTO; ALFONSO, HELDA LIZ; LIPPI, VERONICA; TRABUCO, AMANDA CRISTINA; LAURETTI, FLAVIO; MULLER, VANESSA DANIELLE; et al. Ilheus and Saint Louis encephalitis viruses elicit cross-protection against a lethal Rocio virus challenge in mice. PLoS One, v. 13, n. 6, . (14/02438-6, 14/15548-4, 12/08778-8)
ROJAS, ALEJANDRA; SOARES, ADRIANA MOREIRA; MENDOZA, LAURA PATRICIA; ACOSTA, MARIA EUGENIA; ARIA, LAURA; PAEZ, MALVINA; HEREBIA, LILIAN; VALLEJOS, MARIA ASUNCION; DE GUILLEN, YVALENA; AQUINO, VICTOR HUGO. Revisiting the dengue epidemic of 2011 in Paraguay: molecular epidemiology of dengue virus in the Asuncion metropolitan area. BMC INFECTIOUS DISEASES, v. 21, n. 1, . (14/15548-4)
FIGUEIREDO, G. G.; CORONEL, O. A.; TRABUCO, A. C.; BAZAN, D. E.; RUSSO, R. R.; ALVARENGA, N. L.; AQUINO, V. H.. Steroidal saponins from the roots of Solanum sisymbriifolium Lam. (Solanaceae) have inhibitory activity against dengue virus and yellow fever virus. Brazilian Journal of Medical and Biological Research, v. 54, n. 7, . (14/15548-4)
AMARILLA, ALBERTO A.; SANTOS-JUNIOR, NILTON NASCIMENTO; FIGUEIREDO, MARIO LUIS; MESQUITA LUIZ, JOAO PAULO; FUMAGALLI, MARCILIO JORGE; COLON, DAVID F.; LIPPI, VERONICA; ALFONSO, HELDA LIZ; LIMA-JUNIOR, DJALMA S.; TRABUCO, AMANDA C.; et al. CCR2 Plays a Protective Role in Rocio Virus-Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain. Journal of Infectious Diseases, v. 219, n. 12, p. 2015-2025, . (12/11169-3, 12/08778-8, 14/15548-4, 14/02438-6)

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