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Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects

Grant number: 14/19286-4
Support type:Research Projects - Thematic Grants
Duration: February 01, 2015 - January 31, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Emmanuel de Almeida Burdmann
Grantee:Emmanuel de Almeida Burdmann
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Dirce Maria Trevisan Zanetta ; Leila Antonangelo ; Luis Yu ; Ubiratan de Paula Santos
Assoc. researchers: Ana Valéria de Melo Mendes ; Andrew Simon Levey ; Antonio Abel Portela Neto ; Dionei Ramos ; Elerson Carlos Costalonga ; Etienne Maria Vasconcellos de Macedo ; Fernanda Oliveira Coelho ; Fernando de Assis Ferreira Melo ; Flávia Barros de Azevedo ; George Barberio Coura Filho ; Gilberto de Castro Junior ; Graziela Ramos Barbosa de Souza ; Hiury Silva Andrade ; Lesley Ann Inker ; Lia Junqueira Marçal ; Lucas Braga Mota ; Marceli Rocha Leite ; Marcella Martins Frediani ; Marcelo Tatit Sapienza ; Maria Del Pilar Estevez Diz ; Regis Tironi ; Renato Antunes Caires ; Verônica Torres da Costa e Silva ; William Carlos Nahas
Associated grant(s):18/50006-9 - Brazil-U.S. kidney injury study: a university exchange plan to develop a common protocol for studyng acute kidney injury and chronic kidney disease incidence and prevalence among agricultural workers in Florida, US, and São Paulo, Brazil, AP.R SPRINT
Associated scholarship(s):19/26820-0 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/26624-7 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/26626-0 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
+ associated scholarships 20/00246-3 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/21082-1 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/14404-2 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/12701-0 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
17/25417-2 - Assessment of glomerular filtration rate in cancer patients, BE.PQ
19/08089-7 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/06111-5 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/06336-7 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/06626-5 - Individuals at high risk for developing acute renal injury in relevant clinical settings: prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/03099-4 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/06440-9 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
19/03098-8 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/23927-6 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/22807-7 - Individuals at high risk for developing acute renal injury in relevant clinical settings: prospective study on epidemiological, diagnostic and prognostic aspects, BP.IC
18/22773-5 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/22806-0 - Individuals at high risk for developing acute renal injury in relevant clinical settings: prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/22769-8 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/17524-6 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/17526-9 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/17664-2 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/18576-0 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/18788-7 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/16317-7 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/16906-2 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/13319-9 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/12649-5 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/12650-3 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/13315-3 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/07676-3 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/04637-7 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/07990-0 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/08667-8 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
18/02685-4 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
17/07718-5 - Efficacy of acute tubular injury biomarkers, associated or not to acute kidney injury diagnosis, in morbidity and mortality evaluation of patients doing major abdominal non-vascular surgeries, BP.DR
17/18482-2 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
17/19943-3 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
17/14710-0 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
17/06332-6 - Predictive potential of urinary biomarkers for early diagnosis of acute kidney injury in relevant clinically situations, BP.DD
16/19319-5 - Comparing RIFLE, AKIN and KDIGO diagnostic criteria for acute renal injury incidence in patients undergoing major non vascular abdominal surgeries, BP.IC
15/11594-4 - Comparing incidence of major abdominal nonvascular surgery: associated AKI defined by the diagnoses criteria RIFLE, AKIN and KDIGO, BP.IC
15/06753-6 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
15/06095-9 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT
15/03458-3 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, BP.TT - associated scholarships

Abstract

Acute kidney injury (AKI) is a disease with growing incidence and prevalence, causing high in-hospital and late mortality, increased hospital length of stay, and late development of chronic kidney disease (CKD). It is presumed that this pattern occurs globally, although epidemiological data from developing countries are scarce. In fact, AKI epidemiology has a particular bimodal characteristic in developing countries. In large cities, AKI patients present characteristics similar to those found in developed countries: elderly critically ill patients, with sepsis and multiple organs failure, usually found in intensive care units (ICU). In contrast, in rural areas and small cities, AKI affects young, previously healthy patients, and its etiology is associated to dehydration, infectious diseases, poisonous animal accidents or natural medicines. Recently, three new definitions for AKI were proposed (RIFLE, AKIN and KDIGO), all based in small and abrupt serum creatinine increases or urinary output decrease. However, serum creatinine elevation frequently occurs lately after renal injury occurrence, jeopardizing the institution of preventive maneuvers. Thus, there is an intense search for biomarkers able to perform an early and sensitive detection of kidney injury, as occurs similarly with cardiac troponin. In the same way, the association of these biomarkers and patients' prognosis has been assessed. The early detection of kidney injury and the accurate measurement of the kidney function are particularly important in patients or situations of high risk for AKI. The current research projects collection aims to fulfill important gaps in the knowledge of AKI in high-risk patients (ICU, Clinical Emergency Room, trauma, cancer, major non-cardiac surgeries, cisplatin use, and dehydration associated to exhausting work). They include a comparison of the three new diagnostic criteria prospectively performed, an analysis of kidney injury biomarkers efficacy for early AKI diagnostic and its role in patients' prognosis, a study on the mechanism of renal function changes in dehydration conditions associated to extenuating work (sugarcane harvesting) and an analysis of formulas used for kidney function assessment in cancer patients. We will be able to estimate AKI incidence and/or prevalence in socioeconomic vulnerable populations in our environment, including critically ill patients from Northern Brazil and sugarcane harvesting workers. The results will constitute an important tool for planning resource allocation and developing of AKI prevention campaigns in our reality, and will constitute the major prospective AKI registry ever obtained in Brazil. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA MELO, FERNANDO DE ASSIS; MACEDO, ETIENNE; FONSECA BEZERRA, ANA CAROLINE; LOPES DE MELO, WALEDYA ARAUJO; MEHTA, RAVINDRA L.; BURDMANN, EMMANUEL DE ALMEIDA; TREVISAN ZANETTA, DIRCE MARIA. A systematic review and meta-analysis of acute kidney injury in the intensive care units of developed and developing countries. PLoS One, v. 15, n. 1 JAN 17 2020. Web of Science Citations: 0.
SPADA, TANIA C.; SILVA, JOSE M. R. D.; FRANCISCO, LUCILA S.; MARCAL, LIA J.; ANTONANGELO, LEILA; ZANETTA, DIRCE M. T.; YU, LUIS; BURDMANN, EMMANUEL A. High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals. PLoS One, v. 13, n. 11 NOV 6 2018. Web of Science Citations: 3.
LEITE, MARCELI ROCHA; TREVISAN ZANETTA, DIRCE MARIA; ANTONANGELO, LEILA; MARCAL, LIA JUNQUEIRA; RAMOS, DIONEI; BURDMANN, EMMANUEL ALMEIDA; SANTOS, UBIRATAN PAULA. Burnt sugarcane harvesting work: effects on pulmonary and systemic inflammatory markers. INHALATION TOXICOLOGY, v. 30, n. 6, p. 205-212, 2018. Web of Science Citations: 0.
BURDMANN, EMMANUEL A.; JHA, VIVEKANAND. Acute kidney injury due to tropical infectious diseases and animal venoms: a tale of 2 continents. Kidney International, v. 91, n. 5, p. 1033-1046, MAY 2017. Web of Science Citations: 10.

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