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Genome-Wide Association Study and target resequencing in racing Quarter Horses

Abstract

Different selection objectives within the Quarter Horse breed led to the formation of groups with distinct skills, including the racing line. With a smaller population size in Brazil, but of great economic representativeness, the racing line show a better performance in short-distance races than any other line or breed, and are the fastest horses and one of the fastest animals in the world. The Quarter Horse can reach a speed of up to 88 km/h and can sprint the quarter mile (approximately 402 m) from a standing position in less than 21 seconds. Although the athletic performance of horses is probably influenced by a large number of genes, as in humans, few genetic variants have so far been related to this trait and this was done exclusively in Thoroughbreds. In view of that the effects of DNA polymorphisms on characteristics are intrinsic parameters of each line or breed in a given environment and considering the lack of information regarding the potential of use of marker-assisted selection in horses, especially in the Quarter Horse, breed of great importance in the world and also in Brazil, the objectives of the present study will be: 1) conduct comprehensive genome-wide association study (GWAS) with performance characteristic in Quarter Horses of the racing line using equines high-density SNP genotyping arrays; 2) sequencing genomic regions of interest, significantly associated at GWAS, in order to prospect for genetic polymorphisms direct responsible (causal)or in strong linkage disequilibrium with racing performance. For this, genotypic and phenotypic information from 356 Quarter Horses of the racing line, of both sexes and registered in breed association, will be used. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CURI, R. A.; PEREIRA, G. L.; ALVAREZ, M. V. N.; BALDASSINI, W. A.; MACHADO NETO, O. R.; CHARDULO, L. A. L. Exome analysis and functional classification of identified variants in racing Quarter Horses. ANIMAL GENETICS, v. 51, n. 5 JUL 2020. Web of Science Citations: 0.
MACIEL, S. V. S. A.; DE QUEIROZ, V. H. O.; DE OLIVEIRA, C. A. A.; DE GODOI, F. N.; PEREIRA, G. L.; CURI, R. A.; COSTA, R. B.; DE CAMARGO, G. M. F. Genetic heterogeneity of white markings in Quarter Horses. LIVESTOCK SCIENCE, v. 232, FEB 2020. Web of Science Citations: 0.
PEREIRA, GUILHERME L.; MALHEIROS, JESSICA M.; OSPINA, ALEJANDRA M. T.; CHARDULO, LUIS ARTUR L.; CURI, ROGERIO A. Exome sequencing in genomic regions related to racing performance of Quarter Horses. JOURNAL OF APPLIED GENETICS, v. 60, n. 1, p. 79-86, FEB 2019. Web of Science Citations: 1.
MARCHIORI, CINTIA MARIA; PEREIRA, GUILHERME L.; MAIORANO, AMANDA M.; ROGATTO, GABRIEL M.; ASSONI, AMANDA D.; SILVA, JOSINEUDSON AUGUSTO I. I. V.; CHARDULO, LUIS ARTUR L.; CURI, ROGERIO A. Linkage disequilibrium and population structure characterization in the cutting and racing lines of Quarter Horses bred in Brazil. LIVESTOCK SCIENCE, v. 219, p. 45-51, JAN 2019. Web of Science Citations: 4.
DE MATTEIS, RAFAEL; PEREIRA, GUILHERME L.; CASAROTTO, LETICIA T.; TAVERNARO, ANNA JULIA S.; SILVA, V, JOSINEUDSON AUGUSTO I. I.; CHARDULO, LUIS ARTUR L.; CURI, ROGERIO A. Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses. Journal of Equine Veterinary Science, v. 71, p. 75-83, DEC 2018. Web of Science Citations: 0.
PEREIRA, G. L.; CHARDULO, L. A.; SILVA, J. A. I. I. V.; FARIA, R.; CURI, R. A. Genomic regions associated with performance in racing line of Quarter Horses. LIVESTOCK SCIENCE, v. 211, p. 42-51, MAY 2018. Web of Science Citations: 3.
PEREIRA, GUILHERME L.; CHUD, TATIANE C. S.; BERNARDES, PRISCILA A.; VENTURINI, GUILHERME C.; CHARDULO, LUIS A. L.; CURI, ROGERIO A. Genotype Imputation and Accuracy Evaluation in Racing Quarter Horses Genotyped Using Different Commercial SNP Panels. Journal of Equine Veterinary Science, v. 58, p. 89-96, NOV 2017. Web of Science Citations: 5.
FONSECA, MAYARA GONCALVES; FERRAZ, GUILHERME DE CAMARGO; LAGE, JESSICA; PEREIRA, GUILHERME LUIS; CURI, ROGERIO ABDALLAH. A Genome-Wide Association Study Reveals Differences in the Genetic Mechanism of Control of the Two Gait Patterns of the Brazilian Mangalarga Marchador Breed. Journal of Equine Veterinary Science, v. 53, p. 64-67, JUN 2017. Web of Science Citations: 7.

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