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Study of natural compounds with antifungal activity to elucidate the action mechanism


Trichophyton rubrum (T. rubrum) is the main etiological agent of dermatophytosis in the world. Despite the increased incidence of fungal infections, there are few drugs on the market and their targets are limited because of cell similarities shared between fungi and mammalian. The search for new antifungals of natural origin with new targets is increasing due to an increase in the frequency of infectious diseases, as well as multiple drug resistance (MDR). The objective of this project is to evaluate the antifungal activity against T.rubrum of some natural products: trans chalcone, licochalcone, apigenin, itaconic acid, rosmarinic acid, caffeic acid (the active product of propolis), and purified glycoalkaloids of Solanum lycocarpum. Thereafter, we have the prospect to elucidate the mechanisms of action of compounds that showed potential biological activity using molecular (gene expression by microarray, real time PCR or array) and cellular assays (morphologic changes in membrane damage, quantification of ergosterol and protoplast regeneration). (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MICHELOTTO CANTELLI, BRUNA ALINE; BITENCOURT, TAMIRES APARECIDA; KOMOTO, TATIANA TAKAHASI; BELEBONI, RENE OLIVEIRA; MARINS, MOZART; FACHIN, ANA LUCIA. Caffeic acid and licochalcone A interfere with the glyoxylate cycle of Trichophyton rubrum. BIOMEDICINE & PHARMACOTHERAPY, v. 96, p. 1389-1394, DEC 2017. Web of Science Citations: 4.
FRANCO, MATHEUS ELOY; BITENCOURT, TAMIRES APARECIDA; MARINS, MOZART; FACHIN, ANA LUCIA. In silico characterization of tandem repeats in Trichophyton rubrum and related dermatophytes provides new insights into their role in pathogenesis. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, JUN 11 2017. Web of Science Citations: 0.
BITENCOURT, TAMIRES APARECIDA; MACEDO, CLAUDIA; FRANCO, MATHEUS ELOY; ASSIS, AMANDA FREIRE; KOMOTO, TATIANA TAKAHASI; STEHLING, ELIANA GUEDES; BELEBONI, RENE OLIVEIRA; MALAVAZI, IRAN; MARINS, MOZART; FACHIN, ANA LUCIA. Transcription profile of Trichophyton rubrum conidia grown on keratin reveals the induction of an adhesin-like protein gene with a tandem repeat pattern. BMC Genomics, v. 17, MAR 18 2016. Web of Science Citations: 10.

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