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An approach of the paradigms related to perioperative fluid therapy in small animals


Proper choice of the type of fluid and of the amount of fluid to be administered is seminal for maintaining cell homeostasis. This research proposal aims to approach these 2 paradigms of perioperative fluid therapy:1) What type of fluid ? Choice of wrong fluid may cause a greater incidence of perioperative complications. Phase 1 of the proposal aims to compare the synthetic colloid Tetrastarch with Lactated Ringer's as volume replacement fluids in dogs submitted to acute normovolemic hemodilution, which is a strategy for preserving autologous blood during major surgical procedures.2) How much fluid?In addition to the choice of the right fluid, the amount of fluid to be administered is a paradigm that has been receiving a great deal of attention in veterinary medicine. Excessive volumes of perioperative fluids result in a greater risk of tissue edema and/or suture dehiscence. On the other hand, administration of inadequate amounts of fluids may compromise tissue perfusion and increase the risk of renal complications. Phase 1 of this research proposal aims to establish the guidelines for determining the adequate amount of fluids in order to optimize the cardiac output (global tissue perfusion). This objective will be achieved by determining the receiver operating characteristics (ROC) curve and of the cut off values for fluid responsiveness (defined as an increase > 15% in cardiac output in response to a fluid challenge of 20 mL/kg of Lactated Ringer's) of dynamic preload indices in mechanically ventilated dogs undergoing orthopedic surgery. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CELEITA-RODRIGUEZ, NATHALIA; TEIXEIRA-NETO, FRANCISCO J.; GAROFALO, NATACHE A.; DALMAGRO, TABATA L.; GIROTTO, CAROLINA H.; OLIVEIRA, GUILLERMO C. V.; SANTOS, IVAN F. C. Comparison of the diagnostic accuracy of dynamic and static preload indexes to predict fluid responsiveness in mechanically ventilated, isoflurane anesthetized dogs. VETERINARY ANAESTHESIA AND ANALGESIA, v. 46, n. 3, p. 276-288, MAY 2019. Web of Science Citations: 0.
DINIZ, MIRIELY S.; TEIXEIRA-NETO, FRANCISCO J.; GONCALVES, DANIELE S.; CELEITA-RODRIGUEZ, NATHALIA; GIROTTO, CAROLINA H.; FONSECA, MARIANA W.; TAKAHIRA, REGINA K. Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE, v. 32, n. 6, p. 1927-1933, NOV-DEC 2018. Web of Science Citations: 1.
DINIZ, M. S.; TEIXEIRA-NETO, F. J.; CELEITA-RODRIGUEZ, N.; GIROTTO, C. H.; FONSECA, M. W.; OLIVEIRA-GARCIA, A. C.; LOPEZ-CASTANEDA, B. Effects of 6% Tetrastarch and Lactated Ringer's Solution on Extravascular Lung Water and Markers of Acute Renal Injury in Hemorrhaged, Isoflurane-Anesthetized Healthy Dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE, v. 32, n. 2, p. 712-721, MAR-APR 2018. Web of Science Citations: 3.

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