Evaluation of prognostic value of monocarboxilate transporters (MCT) in patients with breast cancer

• Grant number: 14/17693-1
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2015
• End date: March 31, 2016
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Beatriz da Costa Aguiar Alves Reis
• Grantee: Beatriz da Costa Aguiar Alves Reis
• Host Institution: Faculdade de Medicina do ABC (FMABC). Organização Social de Saúde. Fundação do ABC. Santo André , SP, Brazil
• Associated researchers: Fernando Luiz Affonso Fonseca

Abstract

Breast cancer is the leading cause of cancer mortality among women and these patients are under the risk of developing metastases. The heterogeneous nature of these metastases makes it difficult not only the definition of healing, as well as the risk factors for its development. Currently, some prognostic markers already assist clinical practice, and the most used are hormone receptors (ER and PR), Her2, Ki-67 antigen and Carbohydrate Antigen 15-3 and carcinoembryonic (CEA and CA 15-3). It is known that tumor cells are highly glycolytic, produce lactate and thrive in excess in hypoxic conditions, resulting in acidosis, a reduction in extracellular pH. One of the most important mechanisms involved in the regulation of intracellular pH is concurrent lactate and proton transport mediated by a family of proteins known as monocarboxylate transporter, MCT. Currently, a list of metabolic targets for anticancer therapies includes the MCT1 and MCT4, members of the MCT family regulated by CD147. This project aims to study the expression of MCT1, MCT4 and CD147 by qPCR in tumor samples and in the mononuclear fraction of the peripheral blood of patients with breast cancer during treatment to evaluate their potential prognostic value. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIRA, D.; TEODORO, T. R.; DA SILVA PINHAL, M. A.; AFFONSO FONSECA, F. L.; DE SOUSA GEHRKE, F.; AZZALIS, L. A.; DE CAMPOS JUNQUEIRA, V. B.; DA COSTA AGUIAR ALVES, B.. Profile of hMSH2 expression in breast tumors and lymph nodes: a preliminary study. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, v. 19, n. 17, p. 3229-3233, SEP 2015. (14/17693-1)

LUZ, MARIA CLAUDIA DE B.; PEREZ, MATHEUS M.; AZZALIS, LIGIA A.; SOUSA, LUIZ VINICIUS DE A.; ADAMI, FERNANDO; FONSECA, FERNANDO L. A.; ALVES, BEATRIZ DA C. A.. Evaluation of MCT1, MCT4 and CD147 Genes in Peripheral Blood Cells of Breast Cancer Patients and Their Potential Use as Diagnostic and Prognostic Markers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 18, n. 4, APR 2017. (14/17693-1)