Myocardial salvage after rescue angioplasty: evaluation by magnetic resonance

• Grant number: 14/11957-7
• Support Opportunities: Regular Research Grants
• Duration: May 01, 2015 - December 31, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Antonio Carlos de Camargo Carvalho
• Grantee: Antonio Carlos de Camargo Carvalho
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Adriano Henrique Pereira Barbosa ; Adriano Mendes Caixeta ; Alfredo Augusto Eyer Rodrigues ; Gilberto Szarf ; Luiz Fernando Ybarra Martins de Oliveira

Abstract

Atherosclerotic disease is responsible for one third of all deaths annually and is a major cause of comorbidities. While atherosclerosis is by itself a benign disease, it often leads to complications such as acute myocardial infarction with ST-segment elevation. Rescue angioplasty is indicated if thrombolytic therapy fails. However, the benefits in reducing mortality and the amount of myocardium effectively saved are not well established. The development of new tools, including cardiac magnetic resonance imaging to identify myocardial area at risk and infarcted increased diagnostic accuracy. However, unlike the context of primary angioplasty, little is known about the relationship between coronary epicardial and microvascular flow after rescue angioplasty and myocardial area saved. The objective of this study is to evaluate whether a relationship exists between these flows and the myocardial area saved identified by MRI. At the end of this research, we hope to contribute to a better understanding of coronary flow and its relation to the amount of heart muscle saved after rescue angioplasty. This is important information that can help understand which cases benefit most from rescue angioplasty. (AU)