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Francesca Giuntini | Liverpool John Moores University - Inglaterra

Abstract

Bottom-up fabrication of nanostructures by supramolecular assembly is an efficient and inexpensive route for the manufacture of a variety of smart materials. Peptide- and carbohydrates low molecular weight organic gelators (LMWOG) can self-assemble to form biocompatible materials with versatile chemical properties, displaying great potential for biomedical applications. The dipeptide diphenylalanine (FF) is a thoroughly studied LMWOG consisting of two covalently linked phenylalanine units. Chemical species containing the FF unit can self-assemble under different Processing conditions into a variety of structures (e.g.: nanotubes, nanofibres, etc.), and adopt characteristic spatial arrangement to form non-covalent hydrogels with unique viscoelastic properties. Thanks to this behaviour and to their low toxicity, FF-based self-assembled materials found numerous applications in the fields of biosensing, imaging, biomineralisation, and regenerative medicine… (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GERBELLI, BARBARA B.; VASSILIADES, SANDRA V.; ROJAS, JOSE E. U.; PELIN, JULIANE N. B. D.; MANCINI, RODRIGO S. N.; PEREIRA, WALLACE S. G.; AGUILAR, ANDREA M.; VENANZI, MARIANO; CAVALIERI, FRANCESCA; GIUNTINI, FRANCESCA; ALVES, WENDEL A. Hierarchical Self-Assembly of Peptides and its Applications in Bionanotechnology. MACROMOLECULAR CHEMISTRY AND PHYSICS, v. 220, n. 14, SI JUL 2019. Web of Science Citations: 1.
ROJAS, JOSE EDUARDO U.; GERBELLI, BARBARA B.; RIBEIRO, ANDERSON O.; NANTES-CARDOSO, ISELI L.; GIUNTINI, FRANCESCA; ALVES, WENDEL A. Silk fibroin hydrogels for potential applications in photodynamic therapy. Biopolymers, v. 110, n. 2 FEB 2019. Web of Science Citations: 1.
SOUZA, MARCIA I.; PRIETO, TATIANA; RODRIGUES, TIAGO; FERREIRA, FABIO F.; NASCIMENTO, FRANCISCO B.; RIBEIRO, ANDERSON O.; SILVA, EMERSON R.; GIUNTINI, FRANCESCA; ALVES, WENDEL A. Conjugation with L, L-diphenylalanine Self-Assemblies Enhances In Vitro Antitumor Activity of Phthalocyanine Photosensitizer. SCIENTIFIC REPORTS, v. 7, OCT 13 2017. Web of Science Citations: 3.

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