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Different Resistance-Training Regimens Evoked a Similar Increase in Myostatin Inhibitors Expression


The aim of the present study was to investigate the effect of different resistance-training regi- mens (S or P) on the expression of genes related to the MSTN signaling pathway in physically- active men. 29 male subjects with at least 2 years of experience in strength training were assigned to either a strength-training group (S; n = 11) or a power-training group (P; n = 11). The control group (C; n = 7) was composed of healthy physi- cally-active males. The S and the P groups per- formed high- and low-intensity squats, respectively, 3 times per week, for 8 weeks. Muscle biopsies from the vastus lateralis muscle were collected before and after the training period. No change was observed in MSTN, ACTIIB, GASP-1 and FOXO-3A gene expression after the training period. A similar increase in the gene expression of the inhibitory proteins of the MSTN signaling pathway, FLST and FL-3 (~5.5 fold induction, p < 0.01), was detected after the training period. SMAD-7 gene expression was similarly aug- mented after both training protocols (S, ~2.5 fold induction; P, ~2.8 fold induction; p < 0.05). In conclusion, the resistance-training regimens (S and P) activated the expression of inhibitors of the MSTN signaling pathway in a similar manner. (AU)

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