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Evaluating the effect of crotoxin-nanostructured silica SBA-15 complex in chronic pain: immunomodulatory, antinociceptive and antiinflammatory aspects

Grant number: 15/01254-1
Support type:Regular Research Grants
Duration: June 01, 2015 - November 30, 2017
Field of knowledge:Biological Sciences - Pharmacology - General Pharmacology
Principal Investigator:Gisele Picolo
Grantee:Gisele Picolo
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Chronic pain, when compared with other diseases, is one of the most disabling and one type of pain that generates higher costs to healthcare services, becoming a public health problem. This condition may have an inflammatory origin or can be developed due to peripheral nerve injury, and it is often associated with other disorders such as multiple sclerosis (an example of an autoimmune disorder origin). Chronic pain is characterized by sensory alterations (nociception) and other symptoms such as lethargy, depression and anxiety, which features a classic response of systemic disease, suggesting an underlying immune activity. Despite the improvements in chronic pain-related research, its treatment still presents serious difficulties, since, even with the administration of pharmacological treatment there is no complete reversal of the pain condition. In addition, there are constant reports of patients who suffer with undesirable adverse effects. Therefore, studies related to the development of new treatments for this pathology are necessary. It is known that crotoxin, despite the toxic effect, presents at low doses immunomodulatory, anti-inflammatory, antitumor and antinociceptive effects, which makes it a potential drug for the treatment of chronic pain. It is also known that the nanostructured silica SBA-15, when used as an adjuvant, can reduces the toxicity and promotes and increase in the immune response to different compounds. Thus, the aim of this study is to evaluate whether crotoxin, when coupled to silica SBA-15, has its toxic effect decreased and its analgesic effect increased, also evaluating its interference on the immune and inflammatory responses in models of Partial Sciatic Nerve Ligation (PSNL) and Experimental Autoimmune Encephalomyelitis (EAE). (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Novel formulation permits use of toxin extracted from rattlesnake venom to treat chronic pain 
Articles published in other media outlets (84 total):
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LabNetwork: Nova formulação permite usar toxina do veneno da cascavel para tratar dor crônica (23/Apr/2020)
Planeta online: Toxina de veneno de cascavel consegue tratar dor crônica (23/Apr/2020)
Revista Pará: Nova formulação permite usar toxina do veneno da cascavel para tratar dor crônica (23/Apr/2020)
Central das Notícias: Toxina de veneno de cascavel consegue tratar dor crônica (23/Apr/2020)
Fatos do Iguaçu online: Nova formulação permite usar toxina do veneno da cascavel para tratar dor crônica (23/Apr/2020)
Espaço Ecológico no Ar: Nova formulação permite usar toxina do veneno da cascavel para tratar dor crônica (23/Apr/2020)
Agrosoft: NOVA FORMULAÇÃO PERMITE USAR TOXINA DO VENENO DA CASCAVEL PARA TRATAR DOR CRÔNICA (22/Apr/2020)
Blog A Crítica: Nova formulação permite usar toxina do veneno da cascavel para tratar dor crônica (22/Apr/2020)
Diário da Região (São José do Rio Preto, SP) online: Nova formulação permite usar toxina do veneno de cascavel para tratar dor crônica (22/Apr/2020)
Portal da Enfermagem: Nova formulação permite usar toxina do veneno da cascavel para tratar dor crônica (22/Apr/2020)
JC Notícias (São Paulo, SP): Nova formulação permite usar toxina do veneno da cascavel para tratar dor crônica (22/Apr/2020)
Atemporal: Nova formulação permite usar toxina do veneno da cascavel para tratar dor crônica (22/Apr/2020)
Innovaspain (Espanha): Veneno de serpiente de cascabel para combatir el dolor crónico (11/Mar/2020)
News Break (EUA): Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (11/Mar/2020)
Pregon Agropecuario (Argentina): Una innovación hace posible aplicar el veneno de la serpiente de cascabel para tratar el dolor crónico (10/Mar/2020)
NCYT Amazings (Espanha): Una innovación hace posible aplicar el veneno de la serpiente de cascabel para tratar el dolor crónico (09/Mar/2020)
Catalunya Vanguardista (Espanha): Veneno de serpiente cascabel para tratar el dolor crónico (09/Mar/2020)
Herencia Genetica y Enfermedad (Argentina): Nueva formulación de Crotoxina para tratar el dolor crónico (24/Feb/2020)
AuroBlog: We Just Got Closer to Producing Painkillers From Rattlesnake Venom (24/Feb/2020)
International Business Times (Singapura): Snakes or life savers? New painkillers from Rattlesnake venom may provide relief to millions (23/Feb/2020)
ScienceAlert (Austrália): We Just Got Closer to Producing Painkillers From Rattlesnake Venom (22/Feb/2020)
Buffalo X Press: Brazilian Researchers Prove Crotoxin’s Therapeutic Effects Can Cure Chronic Pain (19/Feb/2020)
Daniel Aleart (Argentina): Nueva formulación de Crotoxina para tratar el dolor crónico (19/Feb/2020)
Polit (Rússia): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (18/Feb/2020)
Newstes (Rússia): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (18/Feb/2020)
Polit News (Rússia): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (18/Feb/2020)
SerTox (Argentina): Logran mejor efecto analgésico de la crotoxina al encapsularla en sílice nanoestructurada (18/Feb/2020)
Vechnayamolodost (Rússia): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (18/Feb/2020)
SerTox (Argentina): Better analgesic effect of crotoxin by encapsulating it in nanostructured silica, study (18/Feb/2020)
UGPressa (Rússia): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (18/Feb/2020)
Science Bulletin: Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (18/Feb/2020)
European Pharmaceutical Review: Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (17/Feb/2020)
Phys.Org (Reino Unido): Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (17/Feb/2020)
PressBoltNews (Índia): Health and medical Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (17/Feb/2020)
Bioquick News (EUA): Novel Formulation Permits Use of Toxin from Rattlesnake Venom to Treat Chronic Pain (17/Feb/2020)
Small Tech News: Rattlesnake venom complex or can become a new effective painkiller (17/Feb/2020)
Archyworldys: Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (17/Feb/2020)
IntraMed (Argentina): Estudio en animales con veneno de serpiente de cascabel | Nueva formulación de Crotoxina para tratar el dolor crónico (17/Feb/2020)
Technologie Média: Un nouvel analgésique venant du serpent à sonnette (17/Feb/2020)
FarsNews Agency (Irã): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (17/Feb/2020)
RCTopNews: Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (16/Feb/2020)
News Medical (Austrália): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (16/Feb/2020)
cnBeta (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
The WB Mirror: Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
FBI Reform (EUA): Eurasia Review: Using Toxin From Rattlesnake Venom To Treat Chronic Pain (15/Feb/2020)
QQ.com (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Bizsiziz: Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Lab Manager (Canadá): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Xoer (Austrália): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Tech Sina (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Bio1000 (China): 新的配方允许使用响尾蛇毒液中的毒素治疗慢性疼痛 (15/Feb/2020)
Vijayawada Now (Índia): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Medindia (Índia): Toxin from Rattlesnake Venom to Treat Chronic Pain (15/Feb/2020)
Kejik.com (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
WNDU 16 (EUA): Toxin From Rattlesnake Venom Formulated to Treat Chronic Pain (15/Feb/2020)
KE jūn I zhāiyào: Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Blog WONGCW (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Trap Town (Índia): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Zaker (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Xiang Fang News (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
HEA - Health Essence of Asia Group (Taiwan): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Alien Gossip (Índia): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Obor News: Using Toxin From Rattlesnake Venom To Treat Chronic Pain (15/Feb/2020)
Caiyisou (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
SOHU.com (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
System Daquan (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Niuzhan (China): Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain (15/Feb/2020)
Pharma Jobs: Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
New Atlas (Austrália): Rattlesnake venom compound points to promising new painkiller (14/Feb/2020)
Eurasia Review (Espanha): Using Toxin From Rattlesnake Venom To Treat Chronic Pain (14/Feb/2020)
Tech Deeps: Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
Science Codex: Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
Health Medicine Network (EUA): Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
Long Room (EUA): Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
RCTopNews: Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
SciTech Daily (EUA): Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
7thSpace: Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
Bioengineer (Reino Unido): Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
Nanotechnology Now (EUA): Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
HNewspaper: Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
Scienstack: Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
Scienmag Science Magazine (Reino Unido): Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)
Daily Tend (Paquistão): Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain (14/Feb/2020)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANT'ANNA, MORENA BRAZIL; RIBEIRO LOPES, FLAVIA SOUZA; KIMURA, LOUISE FAGGIONATO; GIARDINI, ALINE CAROLINA; SANT'ANNA, OSVALDO AUGUSTO; PICOLO, GISELE. Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice. TOXINS, v. 11, n. 12 DEC 2019. Web of Science Citations: 1.
ZAMBELLI, VANESSA O.; PICOLO, GISELE; FERNANDES, CARLOS A. H.; FONTES, MARCOS R. M.; CURY, YARA. Secreted Phospholipases A(2) from Animal Venoms in Pain and Analgesia. TOXINS, v. 9, n. 12 DEC 2017. Web of Science Citations: 10.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.