Photodynamic therapy in trigeminal neuralgia

• Grant number: 14/24533-0
• Support Opportunities: Regular Research Grants
• Duration: August 01, 2015 - July 31, 2017
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Marucia Chacur
• Grantee: Marucia Chacur
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Trigeminal neuralgia (NT) is a common cause of facial pain. It has a significant impact on quality of life and socioeconomic functioning of the patient. The International Association for the Study of Pain (IASP) defines NT as a painful unilateral disorder characterized by episodes of pain like an electric shock that begin and end by abrupt way. Among several models of neuropathy using nerve lesion body, the trigeminal nerve has also been an important target. Since the trigeminal nerve is largely responsible for conducting the sensory information arising from the face and neck. In rats, infraorbital nerve, of the maxillary division, is composed almost by sensory fibers and is responsible for supplying the set of whiskers. The chronic constriction injury of the infraorbital nerve (CCI-NIo) which results in a model of chronic pain that can be applied to the study of orofacial neuropathic pain was described by VOS et al. (1994), and subsequently used in other studies, becoming a well established model for the study of NT. The multifactorial etiology of orofacial pain makes diagnosis difficult and impairs the proper choice of pharmacological therapy. Among the main non-pharmacological techniques for the treatment of neuropathies, we highlight the low-level laser (LLLT). In this study we propose a treatment using LLLT, as control of painful symptoms and repair the NIo. For this, we use techniques such as immunoblottig and thermography besides behavioral and electrophysiological testing. And also study the proteins related to the microenvironment of the injury that probably works in the repair of nervous tissue. With that, we will try to better understand the mechanisms involved in laser therapy. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, J. T.; EVANGELISTA, B. G.; VENEGA, R. A. G.; OLIVEIRA, M. E.; CHACUR, M.. EARLY AND LATE BEHAVIORAL CHANGES IN SCIATIC NERVE INJURY MAY BE MODULATED BY NERVE GROWTH FACTOR AND SUBSTANCE P IN RATS: A CHRONIC CONSTRICTION INJURY LONG-TERM EVALUATION. JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, v. 31, n. 2, p. 309-319, APR-JUN 2017. (14/24533-0, 16/14675-8, 12/24408-6)

GIARDINI, ALINE CAROLINA; DOS SANTOS, FABIO MARTINEZ; DA SILVA, JOYCE TEIXEIRA; DE OLIVEIRA, MARA EVANY; MARTINS, DANIEL OLIVEIRA; CHACUR, MARUCIA. Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats. PAIN RESEARCH & MANAGEMENT, 2017. (14/24533-0, 12/24408-6, 10/20026-6, 12/05840-4, 11/22268-0)

CORREIA ROCHA, IGOR RAFAEL; CIENA, ADRIANO POLICAN; ROSA, ALYNE SANTANA; MARTINS, DANIEL OLIVEIRA; CHACUR, MARUCIA. Photobiostimulation reverses allodynia and peripheral nerve damage in streptozotocin-induced type 1 diabetes. Lasers in Medical Science, v. 32, n. 3, p. 495-501, APR 2017. (14/24533-0)

MARTINS, DANIEL OLIVEIRA; DOS SANTOS, FABIO MARTINEZ; CIENA, ADRIANO POLICAN; WATANABE, II-SEI; DE BRITTO, LUIZ ROBERTO G.; DIAS LEMOS, JOSE BENEDITO; CHACUR, MARUCIA. Neuropeptide expression and morphometric differences in crushed alveolar inferior nerve of rats: Effects of photobiomodulation. Lasers in Medical Science, v. 32, n. 4, p. 833-840, MAY 2017. (14/24533-0, 10/20026-6, 12/05840-4)

ROSA, A. S.; FREITAS, M. F.; ROCHA, I. R. C.; CHACUR, M.. Gabapentin decreases microglial cells and reverses bilateral hyperalgesia and allodynia in rats with chronic myositis. European Journal of Pharmacology, v. 799, p. 111-117, MAR 15 2017. (14/24533-0)