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Cross-talk between lipid membrane-photooxidation and toxin/peptides interaction through domain formation

Grant number: 15/07500-4
Support type:Research Grants - Visiting Researcher Grant - International
Duration: October 01, 2015 - June 30, 2016
Field of knowledge:Biological Sciences - Biophysics
Principal Investigator:Rosangela Itri
Grantee:Rosangela Itri
Visiting researcher: André Schroder
Visiting researcher institution: Institut Charles Sadron (ICS), France
Home Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:12/50680-5 - Photosensitization in life sciences, AP.TEM

Abstract

RaftOxiLip is a research project devoted to the elucidation of the fundamental mechanisms by which photo-induced oxidation processes change domain formation in lipid membranes self-assembled from lipid mixtures. At the crossroads of Physics, Chemistry and Biology, RaftOxiLip will address, from a Physical and Biochemical perspective, two key challenges: i) to develop and consolidate methods for imaging under an optical microscope the production and the density of singlet oxygen, a photo-induced oxidizing species in order to ii) to identify and control the organization changes induced by photo-induced oxidation on plasma and model multicomponent lipid membranes. As an outcome, RaftOxiLip is expected not only to bring new insight into the understanding of the modifications of lipid membrane behavior associated with lipid oxidation, but also to open new research pathways to devise strategies for the design of controlled phase separation in lipid membranes and tissue destruction therapy based on oxidative stresses. Moreover, the contributions from the visiting scientist that have a long collaboration history with the guest group, is also expected to significantly impact the technical pedagogical and environment available in the guest laboratory for pursuing efforts towards the understanding of the FAPESP Thematic Grant program 2012/50680-5 of the host laboratory: "Photo-sensitisation in Life Sciences". RaftOxiLip is twin to PepOxiLip, a project presented by professor Carlos Marques, seeking concomitantly support from FAPESP, for a visit of the group of professor Maurício Baptista, also a member of the Thematic Grant program "Photo-sensitisation in Life Sciences". (AU)