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MHC class I chain-related gene A polymorphisms and linkage disequilibrium with HLAB and HLA-C alleles in ocular toxoplasmosis


This study investigated whether polymorphisms of the MICA gene are associated withthe development of eye lesions related to infection by Toxoplasma gondii in a group ofimmunocompetent patients from southeastern Brazil. The study enrolled 297 patientswith serological diagnosis of toxoplasmosis, classified into two distinct groups afterconducting fundoscopic exams according to the presence of ocular scars/lesions (n =148) or absence of ocular scars/lesions (n = 149) due to toxoplasmosis. The group ofpatients with scars/lesions was further subdivided into two groups according to the typeof the ocular manifestation observed: primary (n = 120) or recurrent manifestations (n =28). Genotyping of the MICA and HLA alleles was performed by the polymerase chainreaction-sequence specific oligonucleotide technique (PCR-SSO; One Lambda®) andthe MICA-129 polymorphism (rs1051792) was identified by nested polymerase chainreaction (PCR-RFLP). Significant associations involving MICA polymorphisms were notfound. Although the MICA*002~HLA-B*35 haplotype was associated with increasedrisk of developing ocular toxoplasmosis (p-value = 0.04; OR = 2.20; 95% CI = 1.05-4.60), and the MICA*008~HLA-C*07 haplotype was associated with protection againstthe development of manifestations of ocular toxoplasmosis (p-value = 0.009; OR: 0.44;95% CI: 0.22-0.76), these associations lost statistical significance after adjusting formultiple comparisons. MICA polymorphisms do not appear to influence thedevelopment of ocular lesions in patients diagnosed with toxoplasmosis in this studypopulation. For a better understanding of the influence of MICA~HLA haplotypes asrisk factors for ocular toxoplasmosis we suggest that further studies should beconducted, in particular involving families. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AYO, CHRISTIANE MARIA; DA SILVEIRA CAMARGO, ANA VITORIA; FREDERICO, FABIO BATISTA; SIQUEIRA, RUBENS CAMARGO; PREVIATO, MARIANA; ANTUNES MURATA, FERNANDO HENRIQUE; SILVEIRA-CARVALHO, APARECIDA PERPETUO; BARBOSA, AMANDA PIRES; BRANDAO DE MATTOS, CINARA DE CASSIA; DE MATTOS, LUIZ CARLOS. MHC Class I Chain-Related Gene A Polymorphisms and Linkage Disequilibrium with HLA-B and HLA-C Alleles in Ocular Toxoplasmosis. PLoS One, v. 10, n. 12, . (13/15879-8, 13/25650-8, 13/06580-9, 13/10050-5, 09/17540-2, 15/13723-6)

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