The role of microRNAs in the progression of androgen independent prostate cancer

• Grant number: 15/03582-6
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2015
• End date: August 31, 2017
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Sabrina Thalita dos Reis Faria
• Grantee: Sabrina Thalita dos Reis Faria
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Alberto Azoubel Antunes ; Alexandre Iscaife ; Denis Reis Morais ; José Pontes Junior ; Kátia Ramos Moreira Leite ; Nayara Izabel Viana ; Nelson Gaspar Dip Júnior

Abstract

The proposed study is to analyze the expression profile of microRNAs miR-221, miR-222, miR-23b and miR27b in tissue samples from patients with prostate cancer (CaP) hormone-sensitive and hormone-resistant and also assess the roles of microRNAs and their antagomirs in CaP cell lines LNCaP and PC-3 that will suffer or no exposure to the hormone, and to evaluate the role of these microRNAs in an in vivo model of CaP established with these same lines. (AU)