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Development and implementation of visual evaluation methods: clinical applications and animal models

Grant number: 14/26818-2
Support type:Research Projects - Thematic Grants
Duration: September 01, 2015 - August 31, 2021
Field of knowledge:Humanities - Psychology - Physiological Psychology
Principal researcher:Dora Selma Fix Ventura
Grantee:Dora Selma Fix Ventura
Home Institution: Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
Marcelo Fernandes da Costa
Assoc. researchers: Alvaro Rendon Fuentes ; Anderson Raiol Rodrigues ; Balazs Vince Nagy ; Bruno Duarte Gomes ; Christina Joselevitch ; Daniela Maria Oliveira Bonci ; Einat Hauzman ; Elaine Cristina Zachi ; Francisco Max Damico ; Givago da Silva Souza ; Jan Kremers ; Luiz Carlos de Lima Silveira ; Michel Roux ; Michele Pierotti ; Mirella Gualtieri ; Mirella Telles Salgueiro Barboni ; Russell David Hamer
Associated grant(s):18/07192-6 - FASEB Science Research Conference on Retinal Neurobiology, AR.EXT
16/08976-5 - Multi-User Equipment approved in grant 15/26818-2: computerized stereology system with motorized microscope, AP.EMU
14/06457-5 - Scientific instrumentation in vision research studies at the Vision Laboratory of IPUSP, AV.EXT
Associated scholarship(s):19/18487-0 - The use of psychophysical and electrophysiological visual tests in the identification of biomarkers of the Alzheimers Diseases (AD) progression, BP.DR
19/12973-0 - Assessment of infant vision using an automated video-based eye tracking solution, BP.DR
19/14606-4 - Studies on anomalous trichromacy in humans and non-human primates using a computerized test of color discrimination and genetic analysis of opsin genes., BP.PD
+ associated scholarships 18/05513-0 - Molecular biology training, BP.TT
18/05227-7 - Visual and cognitive and motor development in babies exposed to Zika virus, BP.TT
16/24631-8 - Implications of Zika virus exposure during gestation for the development of visual function, BP.MS
16/14793-0 - Relationship between gestational Zika virus infection (ZIKV) and alterations in visual acuity and color perception in infants up to three years old, BP.MS
16/21573-7 - Visual Evaluarion of newborn babies intra utero infected by Zika virus, BP.MS
16/22007-5 - Optimization of the visual functional ability in patients with macular diseases using visual training programs, BE.PQ
15/22227-2 - Electrophysiological and psychophysical evaluation of visual functions: a comparative study in Alzheimer's disease, glaucomatous neuropathy and age-related macular degeneration, BP.PD
14/25743-9 - Expression of opsins and melanopsins in snakes' retinas: molecular genetics and immunohistochemistry, BP.PD
13/05942-4 - Visual and cognitive assessment of children in the first three years of life that were affected by bilateral congenital cataracts, BP.PD - associated scholarships

Abstract

The assessment of human visual functions is accomplished today with non-invasive psychophysical and electrophysiological methods, made available by recent computational advances which help the display of visual stimuli, the experimental programming, online data analysis, etc. In order to understand the mechanisms responsible for visual losses, still not well understood, human studies using modern psychophysical and electrophysiological techniques are needed, as well as studies in animal models in which direct access to the retina and higher centers is possible. The present project proposes the development of clinical testing protocols and/or new methodologies for the study of the visual system in humans and animals, in conditions of health and disease, with the objectives of understanding pathological mechanisms and of providing tools for early diagnosis and for follow up. The project will investigate the visual system through perceptual tests and psychophysical scaling methods; through pseudo-random electrophysiological responses; through visual functions such as color vision, contrast sensitivity, Vernier acuity, visual perimetry and others; through visual neuropsychology, involving memory and attention to visual stimuli. The performance in several of these tests will be evaluated under different conditions ambient illumination, to test the new illumination resources available in the market, based on LED technology. We will also evaluate the effects of direct current transcrianial stimulation in these functions with the objectives of understanding underlying neural mechanisms and of proposing clinical applications. The color vision experiments will be combined with the genetic determination of visual pigment types for each individual tested in humans and in monkeys, and these molecular techniques will be extended to several questions posed by the evolution of color vision in vertebrates. Pupillometry will be used to evaluate the functions of the recently discovered melanopsin pigment, which is responsible for the pupil light reflex, for circadian rhythms, and several other functions, such as seasonal depression. In animal models patch clamp experiments will be conducted aiming at the understanding of basic visual mechanisms and electro-retinography studies will be run to evaluate retinal mechanisms underlying visual perception and to test therapeutic drugs. The project involves basic and clinical research groups from various institutions: the Vision Lab from the Institute of Psychology at the University of São Paulo, (proponent), the Biological Science Center, the Tropical Medicine Nucleus and the Primate School, from the Federal University of Pará (Brazilian collaborators) and the University of Erlangen, in Germany, and the CNRS in France (overseas collaborators). The project proposes study and work missions among the different research groups with the objective of making available to both national groups the new methods of visual system investigation. (AU)

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Scientific publications (30)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HENRIQUES, LEONARDO DUTRA; HAUZMAN, EINAT; OLIVEIRA BONCI, DANIELA MARIA; CHANG, BELINDA S. W.; PEREIRA CARNEIRO MUNIZ, JOSE AUGUSTO; SOUZA, GIVAGO DA SILVA; DE LIMA SILVEIRA, LUIZ CARLOS; GALVAO, OLAVO DE FARIA; KILPP GOULART, PAULO RONEY; VENTURA, DORA FIX. Uniform trichromacy in Alouatta caraya and Alouatta seniculus: behavioural and genetic colour vision evaluation. Frontiers in Zoology, v. 18, n. 1 JUL 8 2021. Web of Science Citations: 0.
SALGUEIRO BARBONI, MIRELLA TELLES; PASSOS LIBER, ANDRE MAURICIO; JOACHIMSTHALER, ANNEKA; SAOUDI, AMEL; GOYENVALLE, AURELIE; RENDON, ALVARO; ROGER, JEROME E.; VENTURA, DORA FIX; KREMERS, JAN; VAILLEND, CYRILLE. Altered visual processing in the mdx52 mouse model of Duchenne muscular dystrophy. Neurobiology of Disease, v. 152, MAY 2021. Web of Science Citations: 0.
GAZETA, ROSA ESTELA; BERTOZZI, ANA PAULA ANTUNES PASCALICCHIO; DEZENA, RITA DE CASSIA DE AGUIRRE BERNARDES; SILVA, ANDREA CRISTINA BOTELHO; FAJARDO, THAMIRYS COSMO GILLO; CATALAN, DANIEL T.; RIZZO, MARIA DE FATIMA VALENTE; MORON, ANTONIO FERNANDES; SORIANO-ARANDES, ANTONI; CLEMENTE, NURIA SANCHEZ; QUINTELLA, TANIA; VENTURA, DORA FIX; DAMICO, FRANCISCO MAX; FRANCA, VALTENICE DE CASSIA RODRIGUES DE MATOS; DE ALMEIDA, JULIANA PAULA GOMES; ZARA, ANA LAURA DE SENE AMANCIO; PIRES, LUCAS CASTRO; JUNDIAI, COHORT ZIKA VIRUS; PASSOS, SAULO DUARTE. Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus. Viruses-Basel, v. 13, n. 3 MAR 2021. Web of Science Citations: 0.
VIDAL, KALLENE SUMMER; AHER, AVINASH J.; VENTURA, DORA FIX; KREMERS, JAN. The spatial distribution of ERGs reflecting luminance and L-/M-cone-opponent signals. DOCUMENTA OPHTHALMOLOGICA, v. 142, n. 3 JAN 2021. Web of Science Citations: 1.
MANTOVANI, VIVIANI; HAUZMAN, EINAT; CORREDOR, VITOR H.; GOULART, PAULO R. K.; GALVAO, OLAVO; TALEBI, MAURICIO; PESSOA, DANIEL M. A.; SOARES, JULIANA G. M.; FIORANI, MARIO; GATTASS, RICARDO; VENTURA FIX, DORA; BONCI, DANIELA M. O. Genetic variability of the sws1 cone opsin gene among New World monkeys. AMERICAN JOURNAL OF PRIMATOLOGY, v. 82, n. 12 DEC 2020. Web of Science Citations: 0.
SILVA SOUSA, BRUNA RAFAELA; MEDEIROS GONCALVES LOUREIRO, TEREZINHA; KILPP GOULART, PAULO RONEY; TENTES CORTES, MARIA IZABEL; COSTA, MARCELO FERNANDES; OLIVEIRA BONCI, DANIELA MARIA; PORTNOI BARAN, LUIZ CLAUDIO; HAUZMAN, EINAT; VENTURA, DORA FIX; MIQUILINI, LETICIA; SOUZA, GIVAGO SILVA. Specificity of the chromatic noise influence on the luminance contrast discrimination to the color vision phenotype. SCIENTIFIC REPORTS, v. 10, n. 1 OCT 21 2020. Web of Science Citations: 0.
FEITOSA-SANTANA, CLAUDIA; COSTA, MARCELO FERNANDES; FERRAZ, HENRIQUE BALLALAI; ANDRADE, LUIZ AUGUSTO F.; MOURA, ANA LAURA; AMARO JR, EDSON; HAMER, RUSSELL D.; VENTURA, DORA FIX. Visual losses in early-onset and late-onset Parkinson's disease. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, v. 37, n. 5, p. A285-A293, MAY 1 2020. Web of Science Citations: 0.
LIMA, DIEGO DA SILVA; PORTNOI BARAN, LUIZ CLAUDIO; HAMER, RUSSELL DAVID; DA COSTA, MARCELO FERNANDES; VIDAL, KALLENE SUMMER; DAMICO, FRANCISCO MAX; SALGUEIRO BARBONI, MIRELLA TELLES; RODRIGUES DE MATOS FRANCA, VALTENICE DE CASSIA; GOMES MARTINS, CRISTIANE MARIA; TABARES, HEYDI SEGUNDO; DIAS, SARAH LEONARDO; SILVA, LEONARDO APARECIDO; DECLEVA, DIEGO; ZATZ, MAYANA; ANTUNES PASCALICCHIO BERTOZZI, ANA PAULA; GAZETA, ROSA ESTELA; PASSOS, SAULO DUARTE; VENTURA, DORA FIX. Longitudinal visual acuity development in ZIKV-exposed children. JOURNAL OF AAPOS, v. 24, n. 1 FEB 2020. Web of Science Citations: 0.
SALGUEIRO BARBONI, MIRELLA TELLES; VAILLEND, CYRILLE; JOACHIMSTHALER, ANNEKA; PASSOS LIBER, ANDRE MAURICIO; KHABOU, HANEN; ROUX, MICHEL J.; VACCA, OPHELIE; VIGNAUD, LUCILE; DALKARA, DENIZ; GUILLONNEAU, XAVIER; VENTURA, DORA FIX; RENDON, ALVARO; KREMERS, JAN. Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 61, n. 2 FEB 2020. Web of Science Citations: 0.
LACERDA, ELIZA MARIA DA COSTA BRITO; SOUZA, GIVAGO DA SILVA; CORTES, MARIA IZABEL TENTES; RODRIGUES, ANDERSON RAIOL; PINHEIRO, MARIA CONCEICAO NASCIMENTO; SILVEIRA, LUIZ CARLOS DE LIMA; VENTURA, DORA FIX. Comparison of Visual Functions of Two Amazonian Populations: Possible Consequences of Different Mercury Exposure. FRONTIERS IN NEUROSCIENCE, v. 13, JAN 21 2020. Web of Science Citations: 0.
MARCELO FERNANDES COSTA. Health belief model for coronavirus infection risk determinants. Revista de Saúde Pública, v. 54, p. -, 2020. Web of Science Citations: 0.
GROTZNER, SONIA REGINA; DE FARIAS ROCHA, FERNANDO ALLAN; CORREDOR, VITOR HENRIQUE; PASSOS LIBER, ANDRE MAURICIO; HAMASSAKI, DANIA EMI; OLIVEIRA BONCI, DANIELA MARIA; VENTURA, DORA FIX. Distribution of rods and cones in the red-eared turtle retina (Trachemys scripta elegans). JOURNAL OF COMPARATIVE NEUROLOGY, v. 528, n. 9 DEC 2019. Web of Science Citations: 0.
HAUZMAN, EINAT; KALAVA, VENKATASUSHMA; OLIVEIRA BONCI, DANIELA MARIA; VENTURA, DORA FIX. Characterization of the melanopsin gene (Opn4x) of diurnal and nocturnal snakes. BMC Evolutionary Biology, v. 19, n. 1 AUG 28 2019. Web of Science Citations: 0.
HENRIQUES, LEONARDO DUTRA; OLIVEIRA, J. C. P.; BONCI, D. M. O.; LEAO, R. C.; SOUZA, G. S.; SILVEIRA, L. C. L.; GALVAO, O. F.; GOULART, P. R. K.; VENTURA, D. F. Behavioral and genetic color vision evaluation of an albino male capuchin monkey (Sapajusapella). JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVI, v. 205, n. 4, p. 529-536, AUG 2019. Web of Science Citations: 0.
DUQUE-CHICA, GLORIA L.; GRACITELLI, CAROLINA P. B.; MOURA, ANA L. A.; NAGY, BALAZS V.; VIDAL, KALLENE S.; DE MELO, GERALDINE; PARANHOS, JR., AUGUSTO; CAHALI, MICHEL B.; VENTURA, DORA F. Contributions of the Melanopsin-Expressing Ganglion Cells, Cones, and Rods to the Pupillary Light Response in Obstructive Sleep Apnea. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 60, n. 8, p. 3002-3012, JUL 2019. Web of Science Citations: 0.
BITTENCOURT, GUIDO BARBIERI; HAUZMAN, EINAT; OLIVEIRA BONCI, DANIELA MARIA; VENTURA, DORA FIX. Photoreceptors morphology and genetics of the visual pigments of Bothrops jararaca and Crotalus durissus terrificus (Serpentes, Viperidae). VISION RESEARCH, v. 158, p. 72-77, MAY 2019. Web of Science Citations: 1.
SALGUEIRO BARBONI, MIRELLA TELLES; HAUZMAN, EINAT; NAGY, BALAZS VINCE; GOMES MARTINS, CRISTIANE MARIA; AHER, AVINASH J.; TSAI, I, TINA; OLIVERIA BONCI, DANIELA MARIA; VENTURA, DORA FIX; KREMERS, JAN. Electrodiagnosis of dichromacy. VISION RESEARCH, v. 158, p. 135-145, MAY 2019. Web of Science Citations: 0.
CORREDOR, VITOR H.; DA SILVA, FLAVIO T.; BARAN, LUIZ C. P.; VENTURA, DORA F.; JOSELEVITCH, CHRISTINA. Distribution and density of mixed-input ON bipolar cells of the goldfish (Carassius auratus) during growth. JOURNAL OF COMPARATIVE NEUROLOGY, v. 527, n. 5, p. 903-915, APR 1 2019. Web of Science Citations: 0.
AKIBA, HENRIQUE T.; COSTA, MARCELO F.; GOMES, JULY S.; ODA, EDUARDO; SIMURRO, PAULA B.; DIAS, ALVARO M. Neural Correlates of Preference: A Transmodal Validation Study. FRONTIERS IN HUMAN NEUROSCIENCE, v. 13, MAR 18 2019. Web of Science Citations: 0.
VIEIRA DA SILVA MARTINS, ISABELLE CHRISTINE; SOUZA, GIVAGO DA SILVA; BRASIL, ALODIA; HERCULANO, ANDERSON MANOEL; DA COSTA BRITO LACERDA, ELIZA MARIA; RODRIGUES, ANDERSON RAIOL; MARQUES ROSA, ALEXANDRE ANTONIO; VENTURA, DORA FIX; DE OLIVEIRA CASTRO, ANTONIO JOSE; DE LIMA SILVEIRAZ, LUIZ CARLOS. Psychophysical Evaluation of Visual Functions of Ex-Alcoholic Subjects After Prolonged Abstinence. FRONTIERS IN NEUROSCIENCE, v. 13, MAR 6 2019. Web of Science Citations: 0.
COSTA, MARCELO FERNANDES; RODRIGUES MATOS FRANCA, VALTENICE DE CASSIA; SALGUEIRO BARBONI, MIRELLA TELES; VENTURA, DORA FIX. Maturation of Binocular, Monocular Grating Acuity and of the Visual Interocular Difference in the First 2 Years of Life. CLINICAL EEG AND NEUROSCIENCE, v. 49, n. 3, p. 159-170, MAY 2018. Web of Science Citations: 0.
FEITOSA-SANTANA, CLAUDIA; SOUZA, GIVAGO DA SILVA; PUPO SIRIUS, ESAII VENTURA; RODRIGUES, ANDERSON RAIOL; TENTES CORTES, MARIA IZABEL; DE LIMA SILVEIRA, LUIZ CARLOS; VENTURA, DORA FIX. Color vision impairment with low-level methylmercury exposure of an Amazonian population - Brazil. NeuroToxicology, v. 66, p. 179-184, MAY 2018. Web of Science Citations: 2.
AHER, AVINASH J.; MARTINS, CRISTIANE M. G.; BARBONI, MIRELLA T. S.; NAGY, BALAZS V.; HAUZMAN, EINAT; BONCI, DANIELA M. O.; VENTURA, DORA F.; KREMERS, JAN. Electroretinographical determination of human color vision type. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, v. 35, n. 4, p. B92-B99, APR 1 2018. Web of Science Citations: 1.
HUCHZERMEYER, CORD; MARTINS, CRISTIANE M. G.; NAGY, BALAZS; BARBONI, MIRELLA T. S.; VENTURA, DORA F.; COSTA, MARCELO F.; KREMERS, JAN. Photoreceptor-specific light adaptation of critical flicker frequency in trichromat and dichromat observers. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, v. 35, n. 4, p. B106-B113, APR 1 2018. Web of Science Citations: 2.
SALGUEIRO BARBONI, MIRELLA TELLES; SZEPESSY, ZSUZSANNA; VENTURA, DORA FIX; NEMETH, JANOS. Individual Test Point Fluctuations of Macular Sensitivity in Healthy Eyes and Eyes With Age-Related Macular Degeneration Measured With Microperimetry. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, v. 7, n. 2 MAR 2018. Web of Science Citations: 2.
SALGUEIRO BARBONI, MIRELLA TELLES; BUENO, CLARISSA; NAGY, BALAZS VINCE; MAIA, PATRICIA LOBO; MOREIRA VIDAL, KALLENE SUMMER; ALVES, ROSANA CARDOSO; REITER, RUSSEL J.; DO AMARAL, FERNANDA GASPAR; CIPOLLA-NETO, JOSE; VENTURA, DORA FIX. Melanopsin System Dysfunction in Smith-Magenis Syndrome Patients. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 59, n. 1, p. 362-369, JAN 2018. Web of Science Citations: 6.
HAUZMAN, E.; BONCI, D. M. O.; SUAREZ-VILLOTA, E. Y.; NEITZ, M.; VENTURA, D. F. Daily activity patterns influence retinal morphology, signatures of selection, and spectral tuning of opsin genes in colubrid snakes. BMC Evolutionary Biology, v. 17, DEC 11 2017. Web of Science Citations: 6.
SALGUEIRO BARBONI, MIRELLA TELLES; NAGY, BALAZS VINCE; GOMES MARTINS, CRISTIANE MARIA; OLIVERIA BONCI, DANIELA MARIA; HAUZMAN, EINAT; AHER, AVINASH; TSAI, TINA I.; KREMERS, JAN; VENTURA, DORA FIX. L-/M-cone opponency in visual evoked potentials of human cortex. JOURNAL OF VISION, v. 17, n. 9 AUG 2017. Web of Science Citations: 4.
FRANCISCO MAX DAMICO; FÁBIO GASPARIN; GABRIELA LOURENÇON IOSHIMOTO; THAIS ZAMUDIO IGAMI; ARMANDO DA SILVA CUNHA JR.; SILVIA LIGORIO FIALHO; ANDRE MAURICIO LIBER; LUCY HWA-YUE YOUNG; DORA FIX VENTURA. Intravitreal injection of polysorbate 80: a functional and morphological study. Rev. Col. Bras. Cir., v. 44, n. 6, p. -, Dez. 2017.
SALGUEIRO BARBONI, MIRELLA TELLES; GOMES MARTINS, CRISTIANE MARIA; NAGY, BALAZS VINCE; TSAI, TINA; DAMICO, FRANCISCO MAX; DA COSTA, MARCELO FERNANDES; PAVANELLO, RITA DE CASSIA M.; VILACA LOURENCO, NAILA CRISTINA; PEREIRADE CERQUEIRA, ANTONIA MARIA; ZATZ, MAYANA; KREMERS, JAN; VENTURA, DORA FIX. Dystrophin Is Required for Proper Functioning of Luminance and Red-Green Cone Opponent Mechanisms in the Human Retina. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 8, p. 3581-3587, JUL 2016. Web of Science Citations: 1.

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