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Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation

Grant number: 14/50265-3
Support type:BIOTA-FAPESP Program - Thematic Grants
Duration: July 01, 2015 - April 30, 2020
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Norberto Peporine Lopes
Grantee:Norberto Peporine Lopes
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated grant(s):17/50381-1 - Synthesis scale up and metabolic studies of natural and synthetic bioactive compounds, AP.R
Associated scholarship(s):17/22001-0 - Synthesis and evaluation of new heterocyclic compounds as potential antitrypanosomal agents, BP.PD
18/06125-3 - Metabolism and distribution of natural and synthetic xenobiotics: from the understanding of the reactional processes to the generation of tissue images, BP.TT
17/19330-1 - In vitro metabolism of steroidal alkaloids from Solanum paniculatum l. (Solanaceae), BP.MS
+ associated scholarships 17/04819-5 - Computational chemistry in studies of the reactivity of oxazolines: combining theory and experiment, BP.IC
17/08385-0 - Reactivity and thermochemical parameters for lactones: application in mass spectrometry studies, BP.IC
16/06366-5 - Natural and synthetic xenobiotics bioavailability on in vitro models, BP.PD
16/13292-8 - Analysis of nitrogen content in antropic influenced areas in Amazon and Atlantic Forest using a metabolomic tools, BP.PD
16/07787-4 - Development of a computational toolbox for the analysis of chiral molecular systems using vibrational circular dichroism, BP.PD
15/24815-9 - Characterization of high and medium polarity compounds from different Lychnophora species in order to elucidate a new species, BP.IC - associated scholarships

Abstract

Brazil currently holds the largest biodiversity but the national herbal market is based in exotic plants trades. One of the bottlenecks regarding products development from native biodiversity is the lack of clinical and preclinical studies of natural prod (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Bacteria may help frogs attract mates 
In stingless bee species, queens control worker reproduction without castration 

Scientific publications (62)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ORENHA, RENATO P.; GALEMBECK, SERGIO E. How does the pH influences the Ru-NO coordination compounds?. International Journal of Quantum Chemistry, v. 119, n. 20 OCT 15 2019. Web of Science Citations: 0.
PILON, ALAN CESAR; GU, HAIWEI; RAFTERY, DANIEL; BOLZANI, VANDERLAN DA SILVA; LOPES, NORBERTO PEPORINE; CASTRO-GAMBOA, IAN; CARNEVALE NETO, FAUSTO. Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates. Analytical Chemistry, v. 91, n. 16, p. 10413-10423, AUG 20 2019. Web of Science Citations: 0.
DE MELLO, MURILO B. M.; DE OLIVEIRA, ANTONIO A. F.; DE OLIVEIRA, CAROLINE L.; ULTRAMARI, MARIAH A.; GAETA, FERNANDO H. S.; MASCARELLO, ALESSANDRA; GUIMARAES, CRISTIANO R. W.; DE FREITAS, MILLER N.; CUNHA, CARLOS E.; LOURENCO, TIAGO C.; FERREIRA, FERNANDEZ P.; LOPES, JOAO L. C.; CLOSOSKI, GIULIANO C. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity. Journal of the Brazilian Chemical Society, v. 30, n. 7, p. 1415-1424, JUL 2019. Web of Science Citations: 0.
GOZALO-MARCILLA, M.; LUNA, S. P. L.; MOREIRA DA SILVA, R.; CROSIGNANI, N.; LOPES, N. P.; TAYLOR, P. M.; PELLIGAND, L. Characterisation of the in vivo interactions between detomidine and methadone in horses: Pharmacokinetic and pharmacodynamic modelling. EQUINE VETERINARY JOURNAL, v. 51, n. 4, p. 517-529, JUL 2019. Web of Science Citations: 1.
SOUZA, AMAURI ALVES; VESSECCHI, RICARDO; CASTRO-GAMBOA, IAN; FURLAN, MAYSA. Combined use of tandem mass spectrometry and computational chemistry to study 2H-chromenes from Piper aduncum. Journal of Mass Spectrometry, v. 54, n. 7, p. 634-642, JUL 2019. Web of Science Citations: 0.
MAURO, M.; DE GRANDIS, R. A.; CAMPOS, M. L.; BAUERMEISTER, A.; PECCININI, R. G.; PAVAN, F. R.; LOPES, N. P.; DE MORAES, V, N. Acid diterpenes from Copaiba oleoresin (Copaifera langsdorffii): Chemical and plasma stability and intestinal permeability using Caco-2 cells. Journal of Ethnopharmacology, v. 235, p. 183-189, MAY 10 2019. Web of Science Citations: 0.
FUMAGALLI, FERNANDO; GIL DE MELO, SHAIANI MARIA; RIBEIRO, CAMILA MARINGOLO; SOLCIA, MARIANA CRISTINA; PAVAN, FERNANDO ROGERIO; EMERY, FLAVIO DA SILVA. Exploiting the furo [2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters, v. 29, n. 8, p. 974-977, APR 15 2019. Web of Science Citations: 0.
FALCON, TIAGO; PINHEIRO, DANIEL G.; FERREIRA-CALIMAN, MARIA JULIANA; TURATTI, IZABEL C. C.; PINTO DE ABREU, FABIANO C.; GALASCHI-TEIXEIRA, JULIANA S.; MARTINS, JULIANA R.; ELIAS-NETO, MOYSES; SOARES, MICHELLE P. M.; LAURE, MARCELA B.; FIGUEIREDO, VERA L. C.; LOPES, NORBERTO PEPORINE; SIMOES, ZILA L. P.; GAROFALO, CARLOS A.; BITONDI, MARCIA M. G. Exploring integument transcriptomes, cuticle ultrastructure, and cuticular hydrocarbons profiles in eusocial and solitary bee species displaying heterochronic adult cuticle maturation. PLoS One, v. 14, n. 3 MAR 14 2019. Web of Science Citations: 0.
BRUNETTI, ANDRES E.; LYRA, MARIANA L.; MELO, WEILAN G. P.; ANDRADE, LAURA E.; PALACIOS-RODRIGUEZ, PABLO; PRADO, BARBARA M.; HADDAD, CELIO F. B.; PUPO, MONICA T.; LOPES, NORBERTO P. Symbiotic skin bacteria as a source for sex-specific scents in frogs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 116, n. 6, p. 2124-2129, FEB 5 2019. Web of Science Citations: 0.
TEODORO, T. Q.; KOENIS, M. A. J.; RUGER, R.; GALEMBECK, S. E.; BUMA, W. J.; NICU, V. P.; VISSCHER, L. Use of Density Functional Based Tight Binding Methods in Vibrational Circular Dichroism. Journal of Physical Chemistry A, v. 122, n. 49, p. 9435-9445, DEC 13 2018. Web of Science Citations: 0.
TEODORO, T. Q.; KOENIS, M. A. J.; GALEMBECK, S. E.; NICU, V. P.; BUMA, W. J.; VISSCHER, L. Frequency Range Selection Method for Vibrational Spectra. Journal of Physical Chemistry Letters, v. 9, n. 23, p. 6878-6882, DEC 6 2018. Web of Science Citations: 0.
GIMENES, LUISA POSSAMAI; AMARAL, JULIANO GERALDO; MONGE, MARCELO; SEMIR, JOAO; CALLEGARI LOPES, JOAO LUIS; LOPES, NORBERTO PEPORINE; BAUERMEISTER, ANELIZE. Phytochemical and chemotaxonomy investigation of polar crude extract from Eremanthus incanus (Asteraceae, Vernonieae). Biochemical Systematics and Ecology, v. 81, p. 105-108, DEC 2018. Web of Science Citations: 0.
MENEGATTI, CARLA; DA PAIXAO MELO, WEILAN GOMES; CARRAO, DANIEL BLASCKE; MORAES DE OLIVEIRA, ANDERSON RODRIGO; DO NASCIMENTO, FABIO SANTOS; LOPES, NORBERTO PEPORINE; PUPO, MONICA TALLARICO. Paenibacillus polymyxa Associated with the Stingless Bee Melipona scutellaris Produces Antimicrobial Compounds against Entomopathogens. Journal of Chemical Ecology, v. 44, n. 12, p. 1158-1169, DEC 2018. Web of Science Citations: 2.
MOREIRA, DUARDA ANTUNES; PILON, ALAN CESAR; ANDRADE, LAURA ELENA; LOPES, NORBERTO PEPORINE. New Perspectives on Chlorogenic Acid Accumulation in Harvested Leaf Tissue: Impact on Traditional Medicine Preparations. ACS OMEGA, v. 3, n. 12, p. 18380-18386, DEC 2018. Web of Science Citations: 0.
ELIAS, LARISSA G.; SILVA, DENISE B.; SILVA, RICARDO; PENG, YAN-QIONG; YANG, DA-RONG; LOPES, NORBERTO P.; PEREIRA, RODRIGO A. S. A comparative venomic fingerprinting approach reveals that galling and non-galling fig wasp species have different venom profiles. PLoS One, v. 13, n. 11 NOV 8 2018. Web of Science Citations: 1.
MOREIRA, FERNANDA DE LIMA; MOREIRA, MARCELA DE LIMA; PILON, ALAN CESAR; LOPES, NORBERTO PEPORINE. . Planta Medica, v. 84, n. 15, p. 1141-1148, OCT 2018. Web of Science Citations: 1.
DEMARQUE, DANIEL P.; CALLEJON, DANIEL R.; DE OLIVEIRA, GIBSON G.; SILVA, DENISE B.; CAROLLO, CARLOS A.; LOPES, NORBERTO P. The role of tannins as antiulcer agents: a fluorescence-imaging based study. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 4, p. 425-432, JUL-AUG 2018. Web of Science Citations: 3.
DIAS, HERBERT J.; PATROCINIO, ANDRESSA B.; PAGOTTI, MARIANA C.; FUKUI, MURILO J.; RODRIGUES, VANDERLEI; MAGALHAES, LIZANDRA G.; CROTTI, ANTONIO E. M. Schistosomicidal Activity of Dihydrobenzofuran Neolignans. CHEMISTRY & BIODIVERSITY, v. 15, n. 7 JUL 2018. Web of Science Citations: 3.
FREIRE FRANCO, MARCIA SILVANA; DE PAULA, MURILO HELDER; GLOWACKA, PAULINA CECYLIA; FUMAGALLI, FERNANDO; CLOSOSKI, GIULIANO CESAR; EMERY, FLAVIO DA SILVA. Palladium-catalyzed C-H alkenylation of quinoxaline N-oxide enabled by a mono-N-protected amino acid. Tetrahedron Letters, v. 59, n. 26, p. 2562-2566, JUN 27 2018. Web of Science Citations: 1.
ORENHA, RENATO P.; VESSECCHI, RICARDO; GALEMBECK, SERGIO E. The influence of the negative hyperconjugation is relevant for the analysis of the pi-pi{*} conjugation with the mono-substitution and di-substitution of H2C= by O= and/or HN= in trans-buta-1,3-diene?. STRUCTURAL CHEMISTRY, v. 29, n. 3, p. 847-857, JUN 2018. Web of Science Citations: 3.
ORENHA, RENATO PEREIRA; TFOUNI, ELIA; GALEMBECK, SERGIO EMANUEL. How does the total charge and isomerism influence the Ru-NO ammine complexes?. Physical Chemistry Chemical Physics, v. 20, n. 19, p. 13348-13356, MAY 21 2018. Web of Science Citations: 1.
BRUNETTI, ANDRES E.; MARANI, MARIELA M.; SOLDI, RAFAEL A.; MENDONCA, JACQUELINE NAKAU; FAIVOVICH, JULIAN; CABRERA, GABRIELA M.; LOPES, NORBERTO P. Cleavage of Peptides from Amphibian Skin Revealed by Combining Analysis of Gland Secretion and in Situ MALDI Imaging Mass Spectrometry. ACS OMEGA, v. 3, n. 5, p. 5426-5434, MAY 2018. Web of Science Citations: 2.
DA SILVA, RODRIGO M.; GUARATINI, THAIS; JIMENEZ, PAULA C.; FENICAL, WILLIAM; COSTA-LOTUFO, LETICIA V.; VESSECCHI, RICARDO; LOPES, NORBERTO P. Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone. Journal of the Brazilian Chemical Society, v. 29, n. 5, p. 1162-1166, MAY 2018. Web of Science Citations: 0.
PINTO, MERI EMILI F.; NAJAS, JHENNY Z. G.; MAGALHAES, LUMA G.; BOBEY, ANTONIO F.; MENDONCA, JACQUELINE N.; LOPES, NORBERTO P.; LEME, FLAVIA M.; TEIXEIRA, SIMONE P.; TROVO, MARCELO; ANDRICOPULO, ADRIANO D.; KOEHBACH, JOHANNES; GRUBER, CHRISTIAN W.; CILLI, EDUARDO MAFFUD; BOLZANI, VANDERLAN S. Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria. Journal of Natural Products, v. 81, n. 5, p. 1203-1208, MAY 2018. Web of Science Citations: 3.
DA SILVA, RICARDO R.; WANG, MINGXUN; NOTHIAS, LOUIS-FELIX; VAN DER HOOFT, JUSTIN J. J.; CARABALLO-RODRIGUEZ, ANDRES MAURICIO; FOX, EVAN; BALUNAS, MARCY J.; KLASSEN, JONATHAN L.; LOPES, NORBERTO PEPORINE; DORRESTEIN, PIETER C. Propagating annotations of molecular networks using in silico fragmentation. PLOS COMPUTATIONAL BIOLOGY, v. 14, n. 4 APR 2018. Web of Science Citations: 20.
BRUNETTI, A. E.; CARNEVALE NETO, F.; VERA, M. C.; TABOADA, C.; PAVARINI, D. P.; BAUERMEISTER, A.; LOPES, N. P. An integrative omics perspective for the analysis of chemical signals in ecological interactions. CHEMICAL SOCIETY REVIEWS, v. 47, n. 5, p. 1574-1591, MAR 7 2018. Web of Science Citations: 12.
DEMARQUE, DANIEL P.; DA SILVA, RUI M. P.; SANTOS, LEANDRO F.; LEOPOLDINO, ANDREIA M.; ESPREAFICO, ENILZA M.; LOPES, NORBERTO P. Cytotoxicity of Structurally Diverse Anthranoids and Correlation with Mechanism of Action and Side Effects. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, v. 21, p. 347-353, 2018. Web of Science Citations: 0.
SILVA, DANIEL GEDDER; EMERY, FLAVIO DA SILVA. Strategies towards expansion of chemical space of natural product-based compounds to enable drug discovery. Brazilian Journal of Pharmaceutical Sciences, v. 54, n. SI 2018. Web of Science Citations: 0.
GOBBO-NETO, LEONARDO; BAUERMEISTER, ANELIZE; SAKAMOTO, HUMBERTO T.; GOUVEA, DAYANA R.; LOPES, JOAO LUIS C.; LOPES, NORBERTO P. Spatial and Temporal Variations in Secondary Metabolites Content of the Brazilian Arnica Leaves (Lychnophora ericoides Mart., Asteraceae). Journal of the Brazilian Chemical Society, v. 28, n. 12, p. 2382-2390, DEC 2017. Web of Science Citations: 4.
GALEMBECK, SERGIO E.; CARAMORI, GIOVANNI F.; MISTURINI, ALECHANIA; GARCIA, LEONE C.; ORENHA, RENATO P. Metal-Ligand Bonding Situation in Ruthenophanes Containing Multibridged Cyclophanes. Organometallics, v. 36, n. 18, p. 3465-3470, SEP 25 2017. Web of Science Citations: 6.
LANCHOTI FIORI, GIOVANA MARIA; D'AGATE, SALVATORE; ROCHA, ADRIANA; SOARES PEREIRA, ANA MARIA; DELLA PASQUA, O.; LOPES, NORBERTO PEPORINE. Development and validation of a quantification method for cucurbitacins E and I in rat plasma: Application to population pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis, v. 144, n. SI, p. 99-105, SEP 10 2017. Web of Science Citations: 2.
GUARATINI, T.; FEITOSA, L. G. P.; SILVA, D. B.; LOPES, N. P.; LOPES, J. L. C.; VESSECCHI, R. Gas-phase dissociation study of erythrinian alkaloids by electrospray ionization mass spectrometry and computational methods. Journal of Mass Spectrometry, v. 52, n. 9, p. 571-579, SEP 2017. Web of Science Citations: 4.
BRAIDA, BENOIT; GALEMBECK, SERGIO E.; HIBERTY, PHILIPPE C. Ozone and Other 1,3-Dipoles: Toward a Quantitative Measure of Diradical Character. JOURNAL OF CHEMICAL THEORY AND COMPUTATION, v. 13, n. 7, p. 3228-3235, JUL 2017. Web of Science Citations: 7.
NUNES, TULIO M.; OLDROYD, BENJAMIN P.; ELIAS, LARISSA G.; MATEUS, SIDNEI; TURATTI, IZABEL C.; LOPES, NORBERTO P. Evolution of queen cuticular hydrocarbons and worker reproduction in stingless bees. NATURE ECOLOGY & EVOLUTION, v. 1, n. 7 JUL 2017. Web of Science Citations: 7.
VESSECCHI, RICARDO; BORGES, LETICIA DA SILVA; EMERY, FLAVIO DA SILVA; LOPES, NORBERTO PEPORINE. Understanding the fragmentation mechanisms of methoxy-, mesyl-, and tosyl-lapachol derivatives by computational chemistry and mass spectrometry analysis. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, v. 418, n. SI, p. 92-100, JUL 2017. Web of Science Citations: 2.
DE LIMA BATISTA, ANA P.; DE OLIVEIRA-FILHO, ANTONIO G. S.; GALEMBECK, SERGIO E. CO2 Sequestration by Triazolylidene-Derived N-Heterocyclic Olefins: A Computational Study. CHEMISTRYSELECT, v. 2, n. 17, p. 4648-4654, JUN 12 2017. Web of Science Citations: 5.
DE LIMA BATISTA, ANA P.; DE OLIVEIRA-FILHO, ANTONIO G. S.; GALEMBECK, SERGIO E. Photophysical properties and the NO photorelease mechanism of a ruthenium nitrosyl model complex investigated using the CASSCF-in-DFT embedding approach. Physical Chemistry Chemical Physics, v. 19, n. 21, p. 13860-13867, JUN 7 2017. Web of Science Citations: 7.
ORENHA, RENATO P.; ROCHA, MARCUS V. J.; POATER, JORDI; GALEMBECK, SERGIO E.; BICKELHAUPT, F. MATTHIAS. Nature of the Ru-NO Coordination Bond: Kohn-Sham Molecular Orbital and Energy Decomposition Analysis. CHEMISTRYOPEN, v. 6, n. 3, p. 410-416, JUN 2017. Web of Science Citations: 6.
DE OLIVEIRA, GIBSON GOMES; CARNEVALE NETO, FAUSTO; DEMARQUE, DANIEL PECORARO; DE SOUSA PEREIRA-JUNIOR, JOSE ANTONIO; SAMPAIO PEIXOTO FILHO, ROMULO CESAR; DE MELO, SEBASTIAO JOSE; GUEDES DA SILVA ALMEIDA, JACKSON ROBERTO; CALLEGARI LOPES, JOAO LUIZ; LOPES, NORBERTO PEPORINE. Dereplication of Flavonoid Glycoconjugates from Adenocalymma imperatoris-maximilianii by Untargeted Tandem Mass Spectrometry-Based Molecular Networking. Planta Medica, v. 83, n. 7, p. 636-646, MAY 2017. Web of Science Citations: 3.
HABENSCHUS, MAISA DANIELA; MOREIRA, FERNANDA DE LIMA; LOPES, NORBERTO PEPORINE; DE OLIVEIRA, ANDERSON R. M. In Vitro Inhibition of Human CYP450s 1A2, 2C9, 3A4/5, 2D6 and 2E1 by Grandisin. Planta Medica, v. 83, n. 8, p. 727-736, MAY 2017. Web of Science Citations: 4.
SILVA, DENISE BRENTAN; ASCHENBRENNER, ANNA-KATHARINA; LOPES, NORBERTO PEPORINE; SPRING, OTMAR. Direct Analyses of Secondary Metabolites by Mass Spectrometry Imaging (MSI) from Sunflower (Helianthus annuus L.) Trichomes. Molecules, v. 22, n. 5 MAY 2017. Web of Science Citations: 4.
CREVELIN, EDUARDO J.; POSSATO, BRUNA; LOPES, JOAO L. C.; LOPES, NORBERTO P.; CROTTI, ANTONIO E. M. Precursor Ion Scan Mode-Based Strategy for Fast Screening of Polyether lonophores by Copper-Induced Gas-Phase Radical Fragmentation Reactions. Analytical Chemistry, v. 89, n. 7, p. 3929-3936, APR 4 2017. Web of Science Citations: 3.
TABOADA, CARLOS; BRUNETTI, ANDRES E.; PEDRON, FEDERICO N.; NETO, FAUSTO CARNEVALE; ESTRIN, DARIO A.; BARI, SARA E.; CHEMES, LUCA B.; LOPES, NORBERTO PEPORINE; LAGORIO, MARIA G.; FAIVOVICH, JULIAN. Naturally occurring fluorescence in frogs. Proceedings of the National Academy of Sciences of the United States of America, v. 114, n. 14, p. 3672-3677, APR 4 2017. Web of Science Citations: 22.
MOREIRA, FERNANDA L.; MARQUES, LUCAS M. M.; LOPES, NORBERTO P.; DE OLIVEIRA, ANDERSON R. M. In vitro metabolism studies of natural products are crucial in the early development of medicines. PHYTOCHEMISTRY REVIEWS, v. 16, n. 2, p. 355-373, APR 2017. Web of Science Citations: 2.
PERES, RAPHAEL S.; SANTOS, GABRIELA B.; CECILIO, NERRY T.; JABOR, VALQURIA A. P.; NIEHUES, MICHAEL; TORRES, BRUNA G. S.; BUQUI, GABRIELA; SILVA, CARLOS H. T. P.; DALLA COSTA, TERESA; LOPES, NORBERTO P.; NONATO, MARIA C.; RAMALHO, FERNANDO S.; LOUZADA-JUNIOR, PAULO; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; EMERY, FLAVIO S.; ALVES-FILHO, JOSE C. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. ARTHRITIS RESEARCH & THERAPY, v. 19, MAR 7 2017. Web of Science Citations: 5.
DE LIMA BATISTA, ANA PAULA; DE OLIVEIRA-FILHO, ANTONIO G. S.; GALEMBECK, SERGIO EMANUEL. Computationally Designed 1,2,4-Triazolylidene-Derived N-Heterocyclic Olefins for CO2 Capture, Activation, and Storage. ACS OMEGA, v. 2, n. 1, p. 299-307, JAN 2017. Web of Science Citations: 7.
MARCELA T. NAKAMURA; ELIANA H. ENDO; JOÃO PAULO B. DE SOUSA; DANIEL R. CALLEJON; TÂNIA UEDA-NAKAMURA; BENEDITO P. DIAS FILHO; OSVALDO DE FREITAS; CELSO V. NAKAMURA; NORBERTO P. LOPES. Copaiba Oil and Its Constituent Copalic Acid as Chemotherapeutic Agents against Dermatophytes. Journal of the Brazilian Chemical Society, v. 28, n. 8, p. 1377-1383, Ago. 2017. Web of Science Citations: 1.
FUMAGALLI, FERNANDO; EMERY, FLAVIO DA SILVA. Charting the Chemical Reactivity Space of 2,3-Substituted Furo[2,3-b]pyridines Synthesized via the Heterocyclization of Pyridine-N-oxide Derivatives. Journal of Organic Chemistry, v. 81, n. 21, p. 10339-10347, NOV 4 2016. Web of Science Citations: 10.
ORENHA, RENATO P.; GREGORIO, LETICIA R. SAN; GALEMBECK, SERGIO E. Computational study of the interaction between NO, NO+, and NO- with H2O. Journal of Molecular Modeling, v. 22, n. 11 NOV 2016. Web of Science Citations: 2.
BAUERMEISTER, ANELIZE; AGUIAR, FERNANDO ARMANI; MAURIZ MARQUES, LUCAS MACIEL; MALTA, JR., JOSE DOS SANTOS; BARROS, FABIO; CALLEJON, DANIEL ROBERTO; MORAES DE OLIVEIRA, ANDERSON RODRIGO; LOPES, NORBERTO PEPORINE. In Vitro Metabolism Evaluation of the Ergot Alkaloid Dihydroergotamine: Application of Microsomal and Biomimetic Oxidative Model. Planta Medica, v. 82, n. 15, p. 1368-1373, OCT 2016. Web of Science Citations: 3.
DA SILVA SIQUEIRA, EMERSON MICHELL; FELIX-SILVA, JULIANA; LIMA DE ARAUJO, LORENA MARIA; FERNANDES, JULIA MORAIS; CABRAL, BARBARA; DOS SANTOS GOMES, JACYRA ANTUNES; ROQUE, ALAN DE ARAUJO; TOMAZ, JOSE CARLOS; LOPES, NORBERTO PEPORINE; FERNANDES-PEDROSA, MATHEUS DE FREITAS; GIORDANI, RAQUEL BRANDT; ZUCOLOTTO, SILVANA MARIA. Spondias tuberosa (Anacardiaceae) leaves: profiling phenolic compounds by HPLC-DAD and LC-MS/MS and in vivo anti-inflammatory activity. BIOMEDICAL CHROMATOGRAPHY, v. 30, n. 10, p. 1656-1665, OCT 2016. Web of Science Citations: 8.
MOREIRA, FERNANDA DE LIMA; HABENSCHUS, MAISA D.; BARTH, THIAGO; MARQUES, LUCAS M. M.; PILON, ALAN CESAR; BOLZANI, VANDERLAN DA SILVA; VESSECCHI, RICARDO; LOPES, NORBERTO P.; DE OLIVEIRA, ANDERSON R. M. Metabolic profile and safety of piperlongumine. SCIENTIFIC REPORTS, v. 6, SEP 29 2016. Web of Science Citations: 9.
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MURIE, VALTER E.; MARQUES, LUCAS M. M.; SOUZA, GLORIA E. P.; OLIVEIRA, ANDERSON R. M.; LOPES, NORBERTO P.; CLOSOSKI, GIULIANO C. Acetaminophen Prodrug: Microwave-Assisted Synthesis and in vitro Metabolism Evaluation by Mass Spectrometry. Journal of the Brazilian Chemical Society, v. 27, n. 6, p. 1121-1128, JUN 2016. Web of Science Citations: 2.
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LACHI-SILVA, LARISSA; SY, SHERWIN K. B.; VOELKNER, ALEXANDER; BARRETO DE SOUSA, JOAO PAULO; LOPES, JOAO LUIS C.; SILVA, DENISE B.; LOPES, NORBERTO P.; KIMURA, ELZA; DERENDORF, HARTMUT; DINIZ, ANDREA. Simultaneous Characterization of Intravenous and Oral Pharmacokinetics of Lychnopholide in Rats by Transit Compartment Model. Planta Medica, v. 81, n. 12-13, p. 1121-1127, AUG 2015. Web of Science Citations: 5.
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