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Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation

Grant number: 14/50265-3
Support Opportunities:BIOTA-FAPESP Program - Thematic Grants
Duration: July 01, 2015 - June 30, 2020
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Norberto Peporine Lopes
Grantee:Norberto Peporine Lopes
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated grant(s):17/50381-1 - Synthesis scale up and metabolic studies of natural and synthetic bioactive compounds, AP.R SPRINT
Associated scholarship(s):19/22357-4 - Metabolomic analysis of micromolecular biodiversity of the Atlantic Forest, BP.DR
17/22001-0 - Synthesis and evaluation of new heterocyclic compounds as potential antitrypanosomal agents, BP.PD
18/06125-3 - Metabolism and distribution of natural and synthetic xenobiotics: from the understanding of the reactional processes to the generation of tissue images, BP.TT
+ associated scholarships 17/19330-1 - In vitro metabolism of steroidal alkaloids from Solanum paniculatum l. (Solanaceae), BP.MS
17/04819-5 - Computational chemistry in studies of the reactivity of oxazolines: combining theory and experiment, BP.IC
17/08385-0 - Reactivity and thermochemical parameters for lactones: application in mass spectrometry studies, BP.IC
16/06366-5 - Natural and synthetic xenobiotics bioavailability on in vitro models, BP.PD
16/13292-8 - Analysis of nitrogen content in antropic influenced areas in Amazon and Atlantic Forest using a metabolomic tools, BP.PD
16/07787-4 - Development of a computational toolbox for the analysis of chiral molecular systems using vibrational circular dichroism, BP.PD
15/24815-9 - Characterization of high and medium polarity compounds from different Lychnophora species in order to elucidate a new species, BP.IC - associated scholarships

Abstract

Brazil currently holds the largest biodiversity but the national herbal market is based in exotic plants trades. One of the bottlenecks regarding products development from native biodiversity is the lack of clinical and preclinical studies of natural prod (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
El lenguaje químico de los insectos 
Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (80)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BUQUI, GABRIELA AMARAL; GOUVEA, DAYANA RUBIO; SY, SHERWIN K. B.; VOELKNER, ALEXANDER; SINGH, RAVI S. P.; DA SILVA, DENISE BRENTAN; KIMURA, ELZA; DERENDORF, HARTMUT; LOPES, NORBERTO PEPORINE; DINIZ, ANDREA. Pharmacokinetic Evaluation of Avicularin Using a Model-Based Development Approach. Planta Medica, v. 81, n. 5, p. 373-381, . (14/50265-3)
CREVELIN, EDUARDO J.; POSSATO, BRUNA; LOPES, JOAO L. C.; LOPES, NORBERTO P.; CROTTI, ANTONIO E. M.. Precursor Ion Scan Mode-Based Strategy for Fast Screening of Polyether lonophores by Copper-Induced Gas-Phase Radical Fragmentation Reactions. Analytical Chemistry, v. 89, n. 7, p. 3929-3936, . (14/50265-3, 13/20094-0)
MAURIZ MARQUES, LUCAS MACIEL; AGUIAR, FERNANDO ARMANI; DA SILVA, DENISE BRENTAN; CALLEJON, DANIEL ROBERTO; MORAES DE OLIVEIRA, ANDERSON RODRIGO; LOPES, NORBERTO PEPORINE; CALLEGARI LOPES, JOAO LUIS; GUARATINI, THAIS. Microsomal metabolism of erythraline: an anxiolitic spiroalkaloid. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 25, n. 5, p. 529-532, . (14/20302-4, 11/13281-2, 12/18031-7, 09/51812-0, 14/50265-3)
DE LIMA BATISTA, ANA PAULA; DE OLIVEIRA-FILHO, ANTONIO G. S.; GALEMBECK, SERGIO EMANUEL. Computationally Designed 1,2,4-Triazolylidene-Derived N-Heterocyclic Olefins for CO2 Capture, Activation, and Storage. ACS OMEGA, v. 2, n. 1, p. 299-307, . (14/50265-3, 15/22203-6, 08/02677-0, 15/11714-0)
PERES, RAPHAEL S.; SANTOS, GABRIELA B.; CECILIO, NERRY T.; JABOR, VALQURIA A. P.; NIEHUES, MICHAEL; TORRES, BRUNA G. S.; BUQUI, GABRIELA; SILVA, CARLOS H. T. P.; DALLA COSTA, TERESA; LOPES, NORBERTO P.; et al. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. ARTHRITIS RESEARCH & THERAPY, v. 19, . (12/20990-2, 12/25075-0, 13/08216-2, 14/50265-3, 09/54014-7)
MURIE, VALTER E.; MARQUES, LUCAS M. M.; SOUZA, GLORIA E. P.; OLIVEIRA, ANDERSON R. M.; LOPES, NORBERTO P.; CLOSOSKI, GIULIANO C.. Acetaminophen Prodrug: Microwave-Assisted Synthesis and in vitro Metabolism Evaluation by Mass Spectrometry. Journal of the Brazilian Chemical Society, v. 27, n. 6, p. 1121-1128, . (15/12811-9, 13/17658-9, 14/50265-3)
TRENTIN, DANIELLE S.; SILVA, DENISE B.; FRASSON, AMANDA P.; RZHEPISHEVSKA, OLENA; DA SILVA, MARCIA V.; PULCINI, ELINOR DE L.; JAMES, GARTH; SOARES, GABRIEL V.; TASCA, TIANA; RAMSTEDT, MADELEINE; et al. Natural Green Coating Inhibits Adhesion of Clinically Important Bacteria. SCIENTIFIC REPORTS, v. 5, . (09/54098-6, 12/18031-7, 14/50265-3)
GUARATINI, T.; FEITOSA, L. G. P.; SILVA, D. B.; LOPES, N. P.; LOPES, J. L. C.; VESSECCHI, R.. Gas-phase dissociation study of erythrinian alkaloids by electrospray ionization mass spectrometry and computational methods. Journal of Mass Spectrometry, v. 52, n. 9, p. 571-579, . (14/50265-3, 14/23604-1, 11/13281-2)
GALEMBECK, SERGIO E.; CARAMORI, GIOVANNI F.; MISTURINI, ALECHANIA; GARCIA, LEONE C.; ORENHA, RENATO P.. Metal-Ligand Bonding Situation in Ruthenophanes Containing Multibridged Cyclophanes. Organometallics, v. 36, n. 18, p. 3465-3470, . (08/02677-0, 14/50265-3, 15/15176-2, 11/20351-7)
DEMARQUE, DANIEL P.; CALLEJON, DANIEL R.; DE OLIVEIRA, GIBSON G.; SILVA, DENISE B.; CAROLLO, CARLOS A.; LOPES, NORBERTO P.. The role of tannins as antiulcer agents: a fluorescence-imaging based study. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 4, p. 425-432, . (14/50265-3, 14/18052-0)
NUNES, TULIO M.; OLDROYD, BENJAMIN P.; ELIAS, LARISSA G.; MATEUS, SIDNEI; TURATTI, IZABEL C.; LOPES, NORBERTO P.. Evolution of queen cuticular hydrocarbons and worker reproduction in stingless bees. NATURE ECOLOGY & EVOLUTION, v. 1, n. 7, . (13/09263-4, 14/50265-3, 13/01918-1)
DA SILVA, RODRIGO M.; GUARATINI, THAIS; JIMENEZ, PAULA C.; FENICAL, WILLIAM; COSTA-LOTUFO, LETICIA V.; VESSECCHI, RICARDO; LOPES, NORBERTO P.. Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone. Journal of the Brazilian Chemical Society, v. 29, n. 5, p. 1162-1166, . (14/50265-3)
MAURO, M.; DE GRANDIS, R. A.; CAMPOS, M. L.; BAUERMEISTER, A.; PECCININI, R. G.; PAVAN, F. R.; LOPES, N. P.; DE MORAES, V, N.. Acid diterpenes from Copaiba oleoresin (Copaifera langsdorffii): Chemical and plasma stability and intestinal permeability using Caco-2 cells. Journal of Ethnopharmacology, v. 235, p. 183-189, . (14/50265-3)
SILVA, DANIEL GEDDER; EMERY, FLAVIO DA SILVA. Strategies towards expansion of chemical space of natural product-based compounds to enable drug discovery. Brazilian Journal of Pharmaceutical Sciences, v. 54, n. SI, . (17/21146-4, 17/22001-0, 14/50265-3)
LANCHOTI FIORI, GIOVANA MARIA; D'AGATE, SALVATORE; ROCHA, ADRIANA; SOARES PEREIRA, ANA MARIA; DELLA PASQUA, O.; LOPES, NORBERTO PEPORINE. Development and validation of a quantification method for cucurbitacins E and I in rat plasma: Application to population pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis, v. 144, n. SI, p. 99-105, . (14/50265-3, 12/14408-9)
DE LIMA BATISTA, ANA P.; DE OLIVEIRA-FILHO, ANTONIO G. S.; GALEMBECK, SERGIO E.. Photophysical properties and the NO photorelease mechanism of a ruthenium nitrosyl model complex investigated using the CASSCF-in-DFT embedding approach. Physical Chemistry Chemical Physics, v. 19, n. 21, p. 13860-13867, . (14/50265-3, 15/22203-6, 08/02677-0, 15/11714-0)
DE LIMA BATISTA, ANA P.; DE OLIVEIRA-FILHO, ANTONIO G. S.; GALEMBECK, SERGIO E.. CO2 Sequestration by Triazolylidene-Derived N-Heterocyclic Olefins: A Computational Study. CHEMISTRYSELECT, v. 2, n. 17, p. 4648-4654, . (14/50265-3, 15/22203-6, 08/02677-0, 15/11714-0)
ORENHA, RENATO P.; ROCHA, MARCUS V. J.; POATER, JORDI; GALEMBECK, SERGIO E.; BICKELHAUPT, F. MATTHIAS. Nature of the Ru-NO Coordination Bond: Kohn-Sham Molecular Orbital and Energy Decomposition Analysis. CHEMISTRYOPEN, v. 6, n. 3, p. 410-416, . (08/02677-0, 14/50265-3, 15/15176-2, 11/20351-7)
GOBBO-NETO, LEONARDO; BAUERMEISTER, ANELIZE; SAKAMOTO, HUMBERTO T.; GOUVEA, DAYANA R.; LOPES, JOAO LUIS C.; LOPES, NORBERTO P.. Spatial and Temporal Variations in Secondary Metabolites Content of the Brazilian Arnica Leaves (Lychnophora ericoides Mart., Asteraceae). Journal of the Brazilian Chemical Society, v. 28, n. 12, p. 2382-2390, . (14/20302-4, 14/50265-3)
VESSECCHI, RICARDO; BORGES, LETICIA DA SILVA; EMERY, FLAVIO DA SILVA; LOPES, NORBERTO PEPORINE. Understanding the fragmentation mechanisms of methoxy-, mesyl-, and tosyl-lapachol derivatives by computational chemistry and mass spectrometry analysis. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, v. 418, n. SI, p. 92-100, . (14/50265-3, 14/23604-1)
BRAIDA, BENOIT; GALEMBECK, SERGIO E.; HIBERTY, PHILIPPE C.. Ozone and Other 1,3-Dipoles: Toward a Quantitative Measure of Diradical Character. JOURNAL OF CHEMICAL THEORY AND COMPUTATION, v. 13, n. 7, p. 3228-3235, . (14/50265-3, 08/02677-0)
MOREIRA, FERNANDA L.; MARQUES, LUCAS M. M.; LOPES, NORBERTO P.; DE OLIVEIRA, ANDERSON R. M.. In vitro metabolism studies of natural products are crucial in the early development of medicines. PHYTOCHEMISTRY REVIEWS, v. 16, n. 2, p. 355-373, . (14/50265-3, 13/04188-4, 13/16496-5, 16/07597-0)
DE OLIVEIRA, GIBSON GOMES; CARNEVALE NETO, FAUSTO; DEMARQUE, DANIEL PECORARO; DE SOUSA PEREIRA-JUNIOR, JOSE ANTONIO; SAMPAIO PEIXOTO FILHO, ROMULO CESAR; DE MELO, SEBASTIAO JOSE; GUEDES DA SILVA ALMEIDA, JACKSON ROBERTO; CALLEGARI LOPES, JOAO LUIZ; LOPES, NORBERTO PEPORINE. Dereplication of Flavonoid Glycoconjugates from Adenocalymma imperatoris-maximilianii by Untargeted Tandem Mass Spectrometry-Based Molecular Networking. Planta Medica, v. 83, n. 7, p. 636-646, . (14/50265-3, 14/12343-2)
PINA, EDIEIDIA S.; SILVA, DENISE B.; TEIXEIRA, SIMONE P.; COPPEDE, JULIANA S.; FURLAN, MAYSA; FRANCA, SUZELEI C.; LOPES, NORBERTO P.; PEREIRA, ANA MARIA S.; LOPES, ADRIANA A.. Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging. SCIENTIFIC REPORTS, v. 6, . (09/54098-6, 12/18031-7, 10/18132-2, 13/07349-9, 15/26066-3, 14/50265-3)
VELASCO-ALZATE, KAREN Y.; BAUERMEISTER, ANELIZE; TANGERINA, MARCELO M. P.; LOTUFO, TITO M. C.; FERREIRA, MARCELO J. P.; JIMENEZ, PAULA C.; PADILLA, GABRIEL; LOPES, NORBERTO P.; COSTA-LOTUFO, LETICIA V.. Marine Bacteria from Rocas Atoll as a Rich Source of Pharmacologically Active Compounds. MARINE DRUGS, v. 17, n. 12, . (14/50265-3, 15/17177-6)
BUENO, PAULA C. P.; LOPES, NORBERTO P.. Metabolomics to Characterize Adaptive and Signaling Responses in Legume Crops under Abiotic Stresses. ACS OMEGA, v. 5, n. 4, p. 1752-1763, . (14/50265-3, 17/19702-6, 19/08477-7)
NETO, FAUSTO CARNEVALE; GUARATINI, THAIS; COLEPICOLO, PIO; GATES, PAUL J.; LOPES, NORBERTO PEPORINE. Characteristic product ions of acetylene carotenoids by electrospray and nanospray ionization tandem mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 34, n. 16, . (14/50265-3, 14/12343-2)
DEMARQUE, DANIEL P.; DA SILVA, RUI M. P.; SANTOS, LEANDRO F.; LEOPOLDINO, ANDREIA M.; ESPREAFICO, ENILZA M.; LOPES, NORBERTO P.. Cytotoxicity of Structurally Diverse Anthranoids and Correlation with Mechanism of Action and Side Effects. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, v. 21, p. 347-353, . (14/50265-3, 14/18052-0)
TEODORO, T. Q.; KOENIS, M. A. J.; GALEMBECK, S. E.; NICU, V. P.; BUMA, W. J.; VISSCHER, L.. Frequency Range Selection Method for Vibrational Spectra. Journal of Physical Chemistry Letters, v. 9, n. 23, p. 6878-6882, . (16/07787-4, 14/50265-3, 16/23165-3, 08/02677-0)
GIMENES, LUISA POSSAMAI; AMARAL, JULIANO GERALDO; MONGE, MARCELO; SEMIR, JOAO; CALLEGARI LOPES, JOAO LUIS; LOPES, NORBERTO PEPORINE; BAUERMEISTER, ANELIZE. Phytochemical and chemotaxonomy investigation of polar crude extract from Eremanthus incanus (Asteraceae, Vernonieae). Biochemical Systematics and Ecology, v. 81, p. 105-108, . (14/50265-3)
DA SILVA, RICARDO R.; WANG, MINGXUN; NOTHIAS, LOUIS-FELIX; VAN DER HOOFT, JUSTIN J. J.; CARABALLO-RODRIGUEZ, ANDRES MAURICIO; FOX, EVAN; BALUNAS, MARCY J.; KLASSEN, JONATHAN L.; LOPES, NORBERTO PEPORINE; DORRESTEIN, PIETER C.. Propagating annotations of molecular networks using in silico fragmentation. PLOS COMPUTATIONAL BIOLOGY, v. 14, n. 4, . (15/03348-3, 14/50265-3, 14/01884-2)
PILON, ALAN CESAR; GU, HAIWEI; RAFTERY, DANIEL; BOLZANI, VANDERLAN DA SILVA; LOPES, NORBERTO PEPORINE; CASTRO-GAMBOA, IAN; CARNEVALE NETO, FAUSTO. Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates. Analytical Chemistry, v. 91, n. 16, p. 10413-10423, . (14/12343-2, 03/02176-7, 16/13292-8, 14/50265-3, 10/17935-4, 10/07564-9)
ORENHA, RENATO P.; GALEMBECK, SERGIO E.. How does the pH influences the Ru-NO coordination compounds?. International Journal of Quantum Chemistry, v. 119, n. 20, . (14/50265-3, 15/15176-2, 11/20351-7, 08/02677-0)
CLOSOSKI, GIULIANO C.; SOLDI, RAFAEL A.; DA SILVA, RODRIGO M.; GUARATINI, THAIS; LOPES, JOSE N. C.; PEREIRA, PAMELA R. R.; LOPES, JOAO L. C.; DOS SANTOS, THIAGO; MARTINS, RONALDO B.; COSTA, CRISTINA S.; et al. Tenofovir Disoproxil Fumarate: New Chemical Developments and Encouraging in vitro Biological Results for SARS-CoV-2. Journal of the Brazilian Chemical Society, v. 31, n. 8, p. 1552-1556, . (14/50265-3, 18/14150-8, 14/02438-6)
BRUNETTI, ANDRES E.; LYRA, MARIANA L.; MELO, WEILAN G. P.; ANDRADE, LAURA E.; PALACIOS-RODRIGUEZ, PABLO; PRADO, BARBARA M.; HADDAD, CELIO F. B.; PUPO, MONICA T.; LOPES, NORBERTO P.. Symbiotic skin bacteria as a source for sex-specific scents in frogs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 116, n. 6, p. 2124-2129, . (17/26162-8, 15/01001-6, 13/50954-0, 13/50741-7, 14/20915-6, 14/50265-3, 17/23725-1)
GOZALO-MARCILLA, MIGUEL; DA SILVA, RODRIGO MOREIRA; LOUREIRO LUNA, STELIO PACCA; DE OLIVEIRA, ALICE RODRIGUES; FONSECA, MARIANA WERNECK; LOPES, NORBERTO PEPORINE; TAYLOR, POLLY M.; PELLIGAND, LUDOVIC. A possible solution to model nonlinearity in elimination and distributional clearances with alpha(2)-adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, v. 42, n. 6, p. 738-744, . (14/50265-3, 10/08967-0, 17/01425-6, 14/00474-5)
DEMARQUE, DANIEL P.; CALLEJON, DANIEL R.; PINTO, LARISSA G.; GOUVEA, DAYANA R.; DE MORAES, NATALIA V.; LOPES, JOAO L. C.; LOPES, JOSE N. C.; LOPES, NORBERTO P.; GUARATINI, THAIS. Pharmacokinetic disposition of erythraline in rats after intravenous administration. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 29, n. 6, p. 773-777, . (14/50265-3, 14/18052-0)
NETO, FAUSTO CARNEVALE; ANDREO, MARCIO ADRIANO; RAFTERY, DANIEL; CALLEGARI LOPES, JOAO LUIS; LOPES, NORBERTO PEPORINE; CASTRO-GAMBOA, IAN; DE NORONHA SALES MAIA, BEATRIZ HELENA LAMEIRO; COSTA, EMMANOEL VILACA; VESSECCHI, RICARDO. Characterization of aporphine alkaloids by electrospray ionization tandem mass spectrometry and density functional theory calculations. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 34, n. 3, SI, . (14/12343-2, 03/02176-7, 09/08281-3, 14/23604-1, 14/50265-3, 10/07564-9)
SOUZA, AMAURI ALVES; VESSECCHI, RICARDO; CASTRO-GAMBOA, IAN; FURLAN, MAYSA. Combined use of tandem mass spectrometry and computational chemistry to study 2H-chromenes from Piper aduncum. Journal of Mass Spectrometry, v. 54, n. 7, p. 634-642, . (13/07600-3, 17/15014-8, 14/22239-8, 14/50265-3, 14/23604-1)
FUMAGALLI, FERNANDO; GIL DE MELO, SHAIANI MARIA; RIBEIRO, CAMILA MARINGOLO; SOLCIA, MARIANA CRISTINA; PAVAN, FERNANDO ROGERIO; EMERY, FLAVIO DA SILVA. Exploiting the furo [2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters, v. 29, n. 8, p. 974-977, . (14/50265-3, 17/21146-4, 15/06588-5, 18/00163-0)
LANCHOTI FIORI, GIOVANA MARIA; DEMARQUE, DANIEL PECORARO; SOARES PEREIRA, ANA MARIA; KLEIN, VERA L. G.; LOPES, NORBERTO PEPORINE. Cucurbitane Triterpene Glycosides from the Roots of Wilbrandia hibiscoides. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 31, n. 5, . (12/14408-9, 14/50265-3, 14/18052-0)
DA SILVA, RODRIGO MOREIRA; CARRAO, DANIEL BLASCKE; HABENSCHUS, MAISA DANIELA; JIMENEZ, PAULA CHRISTINE; LOPS, NORBERTO PEPORINE; FENICAL, WILLIAM; COSTA-LOTUFO, LETICIA VERA; MORAES DE OLIVEIRA, ANDERSON RODRIGO. Prediction of seriniquinone-drug interactions by in vitro inhibition of human cytochrome P450 enzymes. TOXICOLOGY IN VITRO, v. 65, . (14/50265-3, 14/50945-4, 16/15680-5, 16/06366-5, 18/07534-4)
FERNANDES, EDUARDO FELIPE ALVES; DE OLIVEIRA, ANDERSON R. M.; BARROS, VALERIA PRISCILA; GUARATINI, THAIS; LOPES, NORBERTO PEPORINE. Biomimetic Metabolism of Kaurenoic Acid Validated by Microsomal Reactions. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 30, n. 4, . (14/50265-3, 13/17658-9)
ORENHA, RENATO PEREIRA; TFOUNI, ELIA; GALEMBECK, SERGIO EMANUEL. How does the total charge and isomerism influence the Ru-NO ammine complexes?. Physical Chemistry Chemical Physics, v. 20, n. 19, p. 13348-13356, . (15/15176-2, 08/02677-0, 14/50265-3, 06/53266-4, 11/20351-7)
FONSECA, MONIQUE T.; MORETTI, EDUARDO H.; MARQUES, LUCAS M. M.; MACHADO, BIANCA F.; BRITO, CAMILA F.; GUEDES, JADY T.; KOMEGAE, EVILIN N.; VIEIRA, THAYNA S.; FESTUCCIA, WILLIAM T.; LOPES, NORBERTO P.; et al. A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation. Science Signaling, v. 14, n. 679, . (16/23540-9, 18/03418-0, 17/17403-1, 17/13350-0, 15/19530-5, 16/04921-1, 20/09399-7, 14/50265-3, 14/03719-9, 18/00849-0)
MENEGATTI, CARLA; DA PAIXAO MELO, WEILAN GOMES; CARRAO, DANIEL BLASCKE; MORAES DE OLIVEIRA, ANDERSON RODRIGO; DO NASCIMENTO, FABIO SANTOS; LOPES, NORBERTO PEPORINE; PUPO, MONICA TALLARICO. Paenibacillus polymyxa Associated with the Stingless Bee Melipona scutellaris Produces Antimicrobial Compounds against Entomopathogens. Journal of Chemical Ecology, v. 44, n. 12, p. 1158-1169, . (09/54098-6, 15/01001-6, 13/50954-0, 14/17620-4, 14/50265-3)
GAZOLLA, MATHEUS COUTINHO; MAURIZ MARQUES, LUCAS MACIEL; GAMA E SILVA, MARIANA; MOURA FONTES ARAUJO, MARIA TAIS; MENDES, ROSEMAIRY LUCIANE; GUEDES DA SILVA ALMEIDA, JACKSON ROBERTO; VESSECCHI, RICARDO; LOPES, NORBERTO PEPORINE. Characterization of 3-aminospirostane alkaloids from roots of Solanum paniculatum L. with hepatoprotective activity. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, . (14/50265-3, 17/19330-1, 14/23604-1)
MAURO, MARIANA; DA SILVA, RODRIGO MOREIRA; DE CAMPOS, MICHEL LEANDRO; BAUERMEISTER, ANELIZE; LOPES, NORBERTO PEPORINE; DE MORAES, NATALIA VALADARES. In vitro metabolism of copalic and kaurenoic acids in rat and human liver microsomes. Química Nova, v. 44, n. 6, p. 700-708, . (14/50265-3)
ALAN C. PILON; DENISE M. SELEGATO; RICHARD P. FERNANDES; PAULA C. P. BUENO; DANIELLE R. PINHO; FAUSTO CARNEVALE NETO; RAFAEL T. FREIRE; IAN CASTRO-GAMBOA; VANDERLAN S. BOLZANI; NORBERTO P. LOPES. METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS. Química Nova, v. 43, n. 3, p. 329-354, . (17/19702-6, 14/50265-3, 19/15889-0, 13/07600-3, 17/17850-8, 16/13292-8, 14/50926-0, 14/05935-0, 15/50488-5, 19/08477-7)
BRUNETTI, A. E.; CARNEVALE NETO, F.; VERA, M. C.; TABOADA, C.; PAVARINI, D. P.; BAUERMEISTER, A.; LOPES, N. P.. An integrative omics perspective for the analysis of chemical signals in ecological interactions. CHEMICAL SOCIETY REVIEWS, v. 47, n. 5, p. 1574-1591, . (14/12343-2, 14/20915-6, 14/50265-3, 13/50741-7)
SILVA-JUNIOR, EDUARDO A.; PALUDO, CAMILA R.; AMARAL, JULIANO G.; GALLON, MARILIA E.; GOBBO-NETO, LEONARDO; NASCIMENTO, FABIO S.; LOPES, NORBERTO P.. Chemical Diversity in a Stingless Bee-Plant Symbiosis. ACS OMEGA, v. 4, n. 12, p. 15208-15214, . (14/50265-3, 15/05453-9)
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