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Characterization of genetic and epigenetic alterations in specific genes in HPV-positive and HPV-negative tumors of patients with head and neck squamous cell carcinoma

Grant number: 15/01286-0
Support type:Regular Research Grants
Duration: November 01, 2015 - April 30, 2018
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:André Lopes Carvalho
Grantee:André Lopes Carvalho
Home Institution: Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil
Assoc. researchers:Ana Carolina de Carvalho Peters ; Cristovam Scapulatempo Neto ; Lidia Maria Rebolho Batista Arantes ; Matias Eliseo Melendez

Abstract

Head and Neck Squamous Cell Carcinoma (HNSCC) is associated with high rates of incidence, morbidity and mortality. Currently, the therapy for these patients depends on the determination of tumor stage, however, patients with tumors of the same stage and location can evolve differently. Infection with human papilloma virus (HPV) has been described as an etiologic factor in the development of a subset of these patients, especially in tumors of the oropharynx with differences in clinical presentation, response profiles and treatment outcome.The possibility of identifying molecular markers that may influence the clinical management of these patients is of paramount importance. The presence of hypermethylation in the promoter region of specific genes is associated with repression of gene expression and has been deemed of significance with potential as a molecular marker in several tumors, including HNSCC. In addition, recent studies that performed the whole-exome sequencing of HNSCC samples identified genetic mutations in key genes related to progression of these tumors.Thus, assessment of the molecular profile of HNSCC through different approaches and techniques allows the identification of signaling pathways altered by different mechanisms, whose most representative genes may serve as candidates for diagnostic and prognostic markers as well as therapeutic targets. In view of this, this study aims to assess genetic and epigenetic alterations in specific genes in tumors induced by HPV (HPV-positive) and tumors induced by carcinogens (HPV-negative) of HNSCC patients, enabling the identification of markers that can be used in the clinical practice for a better stratification of the different subgroups of these tumors and consequently, a better determination of the prognosis and delineation of the best treatment design, contributing to the quality of life and better survival rates. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE JESUS, LAIS MACHADO; DOS REIS, MARIANA BISARRO; CARVALHO, RAIANY SANTOS; SCAPULATEMPO NETO, CRISTOVAM; DE ALMEIDA, GISELE CARAVINA; LAUS, ANA CAROLINA; MARCZYNSKI, GABRIELLA TAQUES; LEAL, LETICIA FERRO; MELENDEZ, MATIAS ELISEO; DE MARCHI, PEDRO; MANUEL REIS, RUI; CARVALHO, ANDRE LOPES; DE CARVALHO, ANA CAROLINA. Feasibility of methylatedctDNAdetection in plasma samples of oropharyngeal squamous cell carcinoma patients. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, JUL 2020. Web of Science Citations: 0.
DE CARVALHO, ANA CAROLINA; PERDOMO, SANDRA; DOS SANTOS, WELLINGTON; FERNANDES, GABRIELA CARVALHO; DE JESUS, LAIS MACHADO; CARVALHO, RAIANY SANTOS; SCAPULATEMPO-NETO, CRISTOVAM; DE ALMEIDA, GISELE CARAVINA; SORROCHE, BRUNA PEREIRA; BATISTA ARANTES, LIDIA MARIA REBOLHO; MELENDEZ, MATIAS ELISEO; DE MARCHI, PEDRO; HAYES, NEIL; REIS, RUI MANUEL; CARVALHO, ANDRE LOPES. Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma. SCIENTIFIC REPORTS, v. 10, n. 1 JUN 19 2020. Web of Science Citations: 0.
DE CARVALHO, ANA CAROLINA; MELENDEZ, MATIAS ELISEO; SABATO, CRISTINA DA SILVA; PALMERO, EDENIR INEZ; REBOLHO BATISTA ARANTES, LIDIA MARIA; NETO, CRISTOVAM SCAPULATEMPO; CARVALHO, ANDRE LOPES. Clinical and Molecular Characterization of Surgically Treated Oropharynx Squamous Cell Carcinoma Samples. Pathology & Oncology Research, v. 25, n. 3, p. 1047-1058, JUL 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.