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Pulmonary Paracoccidioidomycosis in isogenic mice: characterization of mediators of natural and acquired immunity which determine resistance to the fungus

Grant number: 98/13766-0
Support type:Research Projects - Thematic Grants
Duration: April 01, 1999 - July 31, 2004
Field of knowledge:Biological Sciences - Immunology
Principal researcher:Vera Lucia Garcia Calich
Grantee:Vera Lucia Garcia Calich
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


It is intended to study the mechanisms of natural immunity which provide protection against Pulmonary Paracoccidioidomycosis and correlate them with the phenomena of adaptive immunity which subsequently establish themselves. The effects of laminin will be studied, on the depletion in vivo of IL-4, IL-12, IFN-g, PMN leucocytes, T CD4 and CD8 cells, in addition to the administration of recombinant IL-12. We will use animals that are resistant and susceptible to the fungus, athymic, euthymic and with deletion of genes (KO for ag cl I, II, IL-4, IL-12). Parameters of natural immunity (chemokines, cytokines, inflammatory cells) will be correlated with those of acquired immunity (cellular and humoral) after several treatments, in different phases after pulmonary infection. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARRUDA, CELINA; VAZ, CELIDÉIA A. C.; CALICH, VERA L. G. Aseptic cure of pulmonary paracoccidioidomycosis can be achieved after a previous subcutaneous immunization of susceptible but not resistant mice. Microbes and Infection, v. 9, n. 6, p. 704-713, May 2007.
ARRUDA, C.; VALENTE-FERREIRA, R. C.; PINA, A.; KASHINO, S. S.; FAZIOLI, R. A.; VAZ, C. A. C.; FRANCO, M. F.; CALICH, V. L. G.; KELLER, A. C. Dual role of Interleukin-4 (IL-4) in pulmonary paracoccidioidomycosis: endogenous IL-4 can induce protection or exacerbation of disease depending on the host genetic pattern. Infection and Immunity, v. 72, n. 7, p. 3932-3940, Jul. 2004.
PINA, ADRIANA; VALENTE-FERREIRA, RITA C.; MOLINARI-MADLUM, EUGÊNIA E. W.; VAZ, CELIDÉIA A. C.; KELLER, ALEXANDRE C.; CALICH, VERA L. G. Absence of Interleukin-4 determines less severe pulmonary Paracoccidioidomycosis associated with impaired Th2 response. Infection and Immunity, v. 72, n. 4, p. 2369-2378, Apr. 2004.

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