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The aerobic training method can determine the existence of cardiac remodeling: structural, functional and molecular analyzes of swimming and running experimental models

Grant number: 15/11028-9
Support type:Regular Research Grants
Duration: November 01, 2015 - October 31, 2017
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Andrey Jorge Serra
Grantee:Andrey Jorge Serra
Home Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
Assoc. researchers:Adriana Castello Costa Girardi ; José Antonio Silva Junior ; Paulo Jose Ferreira Tucci

Abstract

Physical training imposes structural, functional and molecular changes in the heart, which is an adaptive response called physiological cardiac hypertrophy. An issue that raises strong interest is the specific cardiac adaptive response according training modality. Thus, an increased thickness left ventricular (LV) wall as well as reduced LV cavity it has been shown to occur after anaerobic training, which is known as concentric LV hypertrophy. On the other hand, aerobic training induce eccentric cavity remodeling, which show be expressed by an increase in the cavity radius and maintenance or negligible change of wall thickness. Overall, this information led to assume that the cardiac remodeling induced by exercise is a clear issue. However, some issues have shown an opposite position - there is evidence that different types of aerobic exercise training can trigger a distinct parameter of cardiac remodeling. These data support our study, which will be developed on two experimental models (swimming and running) of aerobic exercise training commonly applied to induce cardiac remodeling in rodents. The use of experimental exercise model is suitable for our interest: [1] cardiac remodeling is similar in rats and humans; [2] load, volume, duration and adherence to training program are easily controlled; [3] an exact hypertrophic pattern in response to different aerobic training protocols is also a hypothesis to be defined at experimental models. In fact, our study will provide the following information: [1] swimming and running training programs induce similar morphologic changes in LV; [2] two protocols can induce improvement in LV performance and myocardial inotropic. Moreover, the molecular mechanisms linked to the adaptive process will not be neglected. We will assess whether the swimming and running training can modulate signaling pathway of PI3Kp110alpha/Akt/mTOR, which is critical to cardiac remodeling induced by exercise. The role of training programs on myocardial microRNA's expression is another target of this study. (AU)

Scientific publications (13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GRANDINETTI, VANESSA; CARLOS, FERNANDO P. EREIRA; ANTONIO, EDNEI LUIZ; DE OLIVEIRA, HELENITA ANTONIA; NEVES DOS SANTOS, LUIS FELIPE; YOSHIZAKI, AMANDA; DIAS MARTINS MANSANO, BARBARA SAMPAIO; SILVA, FLAVIO ANDRE; PORTE, LESLIE ANDREWS; ALBUQUERQUE-PONTES, GIANNA MOES; CAMILLO DE CARVALHO, PAULO DE TARSO; MANCHINI, MARTHA TRINDADE; LEAL-JUNIOR, ERNESTO CESAR; FERREIRA TUCCI, PAULO JOSE; SERRA, ANDREY JORGE. Photobiomodulation therapy combined with carvedilol attenuates post-infarction heart failure by suppressing excessive inflammation and oxidative stress in rats. SCIENTIFIC REPORTS, v. 9, JUL 1 2019. Web of Science Citations: 0.
VIEIRA, STELLA DE SOUZA; ANTONIO, EDNEI LUIZ; DE MELO, BRUNNO LEMES; PORTES, LESLIE ANDREWS; MONTEMOR, JAIRO; OLIVEIRA, HELENITA ANTONIA; MARTINS, FLAVIA LETICIA; ZOGBI, CAMILA; GIRARDI, ADRIANA COSTA; SILVA, JR., JOSE ANTONIO; CAMILLO DE CARVALHO, PAULO DE TARSO; FERREIRA TUCCI, PAULO JOSE; SERRA, ANDREY JORGE. Exercise Training Potentiates The Cardioprotective Effects of Stem Cells Post-infarction. HEART LUNG AND CIRCULATION, v. 28, n. 2, p. 263-271, FEB 2019. Web of Science Citations: 2.
ARSA, GISELA; LANZA, FERNANDA CORDOBA; CAMBRI, LUCIELI TERESA; ANTONIO, EDNEI LUIZ; MURAD, NEIF; DE MELLO, MARCO TULIO; SANTOS, ALEXANDRA ALBERTO; CAMILLO DE CARVALHO, PAULO DE TARSO; SILVA-JUNIOR, JOSE ANTONIO; BOCALINI, DANILO SALES; DIAS MARTINS MANSANO, BARBARA SAMPAIO; FERREIRA TUCCI, PAULO JOSE; SERRA, ANDREY JORGE. Predicted Equation for VO2 Based on a 20-Meter Multistage Shuttle Run Test for Children. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 39, n. 14, p. 1049-1054, DEC 2018. Web of Science Citations: 2.
YOSHIZAKI, AMANDA; ANTONIO, EDNEI LUIZ; SILVA JUNIOR, JOSE ANTONIO; CRAJOINAS, RENATO OLIVEIRA; SILVA, FLAVIO ANDRE; COSTA GIRARDI, ADRIANA CASTELLO; BOCALINI, DANILO SALES; PORTES, LESLIE ANDREWS; NEVES DOS SANTOS, LUIS FELIPE; CARLOS, FERNANDO PEREIRA; CAMILLO DE CARVALHO, PAULO DE TARSO; FERREIRA TUCCI, PAULO JOSE; SERRA, ANDREY JORGE. Swimming Training Improves Myocardial Mechanics, Prevents Fibrosis, and Alters Expression of Ca2+ Handling Proteins in Older Rats. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 73, n. 4, p. 468-474, APR 2018. Web of Science Citations: 0.
DA SILVA, MARIANA MOREIRA; ALBERTINI, REGIANE; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR; BUSSADORI, SANDRA KALIL; VIEIRA, STELLA SOUSA; BOCALINI, DANILO SALES; FRANCO DE OLIVEIRA, LUIS VICENTE; GRANDINETTI, VANESSA; SILVA, JR., JOSE ANTONIO; SERRA, ANDREY JORGE. Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment. Lasers in Medical Science, v. 33, n. 2, p. 343-351, FEB 2018. Web of Science Citations: 6.
DE OLIVEIRA, HELENITA ANTONIA; ANTONIO, EDNEI LUIZ; SILVA, FLAVIO ANDRE; CAMILLO DE CARVALHO, PAULO DE TARSO; FELICIANO, REGIANE; YOSHIZAKI, AMANDA; VIEIRA, STELLA DE SOUZA; DE MELO, BRUNNO LEMES; PINTO LEAL-JUNIOR, ERNESTO CESAR; LABAT, RODRIGO; BOCALINI, DANILO SALES; SILVA JUNIOR, JOSE ANTONIO; FERREIRA TUCCI, PAULO JOSE; SERRA, ANDREY JORGE. Protective effects of photobiomodulation against resistance exercise-induced muscle damage and inflammation in rats. JOURNAL OF SPORTS SCIENCES, v. 36, n. 20, p. 2349-2357, 2018. Web of Science Citations: 3.
DE OLIVEIRA, HELENITA ANTONIA; ANTONIO, EDNEI LUIZ; ARSA, GISELA; SANTANA, EDUARDO TADEU; SILVA, FLAVIO ANDRE; ARRUDA JUNIOR, DANIEL; DOS SANTOS, SIMONE; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR; ARAUJO, AMANDA; DE ANGELIS, KATIA; BOCALINI, DANILO SALES; SILVA JUNIOR, JOSE ANTONIO; FERREIRA TUCCI, PAULO JOSE; SERRA, ANDREY JORGE. Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High-Intensity Resistive Exercise. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018. Web of Science Citations: 1.
MANCHINI, MARTHA T.; ANTONIO, EDNEI L.; SILVA JUNIOR, JOSE ANTONIO; DE CARVALHO, PAULO DE TARSO C.; ALBERTINI, REGIANE; PEREIRA, FERNANDO C.; FELICIANO, REGIANE; MONTEMOR, JAIRO; VIEIRA, STELLA S.; GRANDINETTI, VANESSA; YOSHIZAKI, AMANDA; CHAVES, MARCIO; DA SILVA, MOISES P.; DE LIMA, RAFAEL DO NASCIMENTO; BOCALINI, DANILO S.; DE MELO, BRUNO L.; TUCCI, PAULO J. F.; SERRA, ANDREY J. Low-Level Laser Application in the Early Myocardial Infarction Stage Has No Beneficial Role in Heart Failure. FRONTIERS IN PHYSIOLOGY, v. 8, JAN 30 2017. Web of Science Citations: 4.
DOS SANTOS, SOLANGE ALMEIDA; SERRA, ANDREY JORGE; STANCKER, TATIANE GARCIA; BRANDAO SIMOES, MAIRA CECILIA; DOS SANTOS VIEIRA, MARCIA ATAIZE; LEAL-JUNIOR, ERNESTO CESAR; PROKIC, MARKO; VASCONSUELO, ANDREA; SANTOS, SIMONE SILVA; CAMILLO DE CARVALHO, PAULO DE TARSO. Effects of Photobiomodulation Therapy on Oxidative Stress in Muscle Injury Animal Models: A Systematic Review. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017. Web of Science Citations: 4.
LEVY, R. F.; SERRA, A. J.; ANTONIO, E. L.; DOS SANTOS, L.; BOCALINI, D. S.; PESQUERO, J. B.; BADER, M.; MERINO, V. F.; DE OLIVEIRA, H. A.; DE ARRUDA VEIGA, E. C.; SILVA, JR., J. A.; TUCCI, P. J. F. Cardiac Morphofunctional Characteristics of Transgenic Rats With Overexpression of the Bradykinin B1 Receptor in the Endothelium. Physiological Research, v. 66, n. 6, p. 925-932, 2017. Web of Science Citations: 0.
DE MELO, BRUNNO LEMES; VIEIRA, STELLA S.; ANTONIO, EDNEI L.; DOS SANTOS, LUIS F. N.; PORTES, LESLIE A.; FELICIANO, REGIANE S.; DE OLIVEIRA, HELENITA A.; SILVA, JR., JOSE A.; DE CARVALHO, PAULO DE TARSO C.; TUCCI, PAULO J. F.; SERRA, ANDREY J. Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis. FRONTIERS IN PHYSIOLOGY, v. 7, DEC 5 2016. Web of Science Citations: 5.
REIS JUNIOR, DERMEVAL; ANTONIO, EDNEI LUIZ; DE FRANCO, MARCELLO FABIANO; DE OLIVEIRA, HELENITA ANTONIA; FERREIRA TUCCI, PAULO JOSE; SERRA, ANDREY JORGE. Association of Exercise Training with Tobacco Smoking Prevents Fibrosis but has Adverse Impact on Myocardial Mechanics. NICOTINE & TOBACCO RESEARCH, v. 18, n. 12, p. 2268-2272, DEC 2016. Web of Science Citations: 3.
SANTANA, EDUARDO T.; FELICIANO, REGIANE DOS SANTOS; SERRA, ANDREY J.; BRIGIDIO, EDUARDO; ANTONIO, EDNEI L.; TUCCI, PAULO J. F.; NATHANSON, LUBOV; MORRIS, MARIANA; SILVA, JR., JOSE A. Comparative mRNA and MicroRNA Profiling during Acute Myocardial Infarction Induced by Coronary Occlusion and Ablation Radio-Frequency Currents. FRONTIERS IN PHYSIOLOGY, v. 7, NOV 25 2016. Web of Science Citations: 2.

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