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The coadministration of nacetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system

Grant number: 15/21101-5
Support type:Regular Research Grants - Publications - Scientific article
Duration: November 01, 2015 - April 30, 2016
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Wilma de Grava Kempinas
Grantee:Wilma de Grava Kempinas
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Arsenic trioxide (As2O3) has shown effectiveness in treatment of leukemia but is also associated with reproductive toxicity. Since remediation with N-acetylcysteine (NAC) may mitigate the adverse effects caused by exposure, we assessed the effects of As2O3 and its potential reversibility after exposure cessation or co-administration of NAC. Animals received 0.3 or 3.0 mg/Kg/day of As2O3 subcutaneously and 40mM NAC in tap water. As2O3 treatment impaired spermatogenesis, sperm motility, decreased seminal vesicle weight and testosterone serum levels; after suspension of treatment, these parameters remained altered. When administered NAC, animals showed improvement in sperm parameters and seminal vesicle weight. In vitro epididymal contractility was increased in As2O3-treated animals. We concluded that As2O3 is toxic to the male mouse genital system by compromising sperm quality and quantity; these effects persisted even after suspension of the treatment. However, the co-administration of NAC ameliorates the harmful effects of the drug on the male genital system. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, RAQUEL FRENEDOSO; BORGES, CIBELE DOS SANTOS; VILLELA E SILVA, PATRICIA; MISSASSI, GABRIELA; ALMEIDA KIGUTI, LUIZ RICARDO; PUPO, ANDRE SAMPAIO; BARBOSA JUNIOR, FERNANDO; ANSELMO-FRANCI, JANETE APARECIDA; KEMPINAS, WILMA DE GRAVA. The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016. Web of Science Citations: 6.

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