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Brazilian biodiversity as a source for novel drug scaffolds against neglected protozoan diseases

Grant number: 15/50075-2
Support type:Regular Research Grants
Duration: November 01, 2015 - October 31, 2017
Field of knowledge:Biological Sciences - Parasitology
Cooperation agreement: University of Oxford
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:André Gustavo Tempone Cardoso
Grantee:André Gustavo Tempone Cardoso
Principal investigator abroad: Edward Alexander Anderson
Institution abroad: University of Oxford, England
Home Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands, AP.BTA.TEM

Abstract

Brazilian biodiversity has proved a powerful source of small bioactive molecules, which are valuable lead compounds for the development of useful therapeutics. Based ín these aspects, biodiversity conservation and restoration have been high priorities for ... (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Biocompound from Atlantic Rainforest combats leishmaniasis and Chagas disease 

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, DAIANE D.; SOUSA, FERNANDA S.; COSTA-SILVA, THAIS A.; REIMAO, JULIANA Q.; TORRECILHAS, ANA C.; JOHNS, DEIDRE M.; SEAR, CLAIRE E.; HONORIO, KATHIA M.; LAGO, JOAO HENRIQUE G.; ANDERSON, EDWARD A.; TEMPONE, ANDRE G. Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 176, p. 162-174, AUG 15 2019. Web of Science Citations: 1.
AMARAL, MAIARA; DE SOUSA, FERNANDA S.; SILVA, THAIS A. COSTA; JUNIOR, ANDRES JIMENEZ G.; TANIWAKI, NOEMI N.; JOHNS, DEID RE M.; LAGO, JOAO HENRIQUE G.; ANDERSON, EDWARD A.; TEMPONE, ANDRE G. A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division. SCIENTIFIC REPORTS, v. 9, APR 16 2019. Web of Science Citations: 0.
GRECCO, SIMONE S.; COSTA-SILVA, THAIS A.; JERZ, GEROLD; DE SOUSA, FERNANDA S.; LONDERO, VINICIUS S.; GALUPPO, MARIANA K.; LIMA, MARTA L.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G. Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages. Chemico-Biological Interactions, v. 277, p. 55-61, NOV 1 2017. Web of Science Citations: 7.
TEMPONE, ANDRE GUSTAVO; FERREIRA, DAIANE DIAS; LIMA, MARTA LOPES; COSTA SILVA, THAIS ALVES; BORBOREMA, SAMANTA E. T.; REIMAO, JULIANA QUERO; GALUPPO, MARIANA K.; GUERRA, JULIANA MARIOTTI; RUSSELL, ANGELIE J.; WYNNE, GRAHAM M.; LAI, ROY Y. L.; CADELIS, MELISSA M.; COPP, BRENT R. Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 139, p. 947-960, OCT 20 2017. Web of Science Citations: 14.
BAPTISTA CANUTO, GISELE ANDRE; DORR, FABIANE; GHILARDI LAGO, JOAO HENRIQUE; TEMPONE, ANDRE GUSTAVO; PINTO, ERNANI; PIMENTA, DANIEL CARVALHO; SIMON FARAH, JOAO PEDRO; MANSO ALVES, MARIA JULIA; MAGGI TAVARES, MARINA FRANCO. New insights into the mechanistic action of methyldehydrodieugenol B towards Leishmania (L.) infantum via a multiplatform based untargeted metabolomics approach. METABOLOMICS, v. 13, n. 5 MAY 2017. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
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