Brazilian biodiversity as a source for novel drug scaffolds against neglected protozoan diseases

• Grant number: 15/50075-2
• Support Opportunities: Regular Research Grants
• Duration: November 01, 2015 - October 31, 2017
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Convênio/Acordo: University of Oxford
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: André Gustavo Tempone Cardoso
• Grantee: André Gustavo Tempone Cardoso
• Principal researcher abroad: Edward Alexander Anderson
• Institution abroad: University of Oxford, England
• Host Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach, AP.BTA.TEM

Abstract

Brazilian biodiversity has proved a powerful source of small bioactive molecules, which are valuable lead compounds for the development of useful therapeutics. Based ín these aspects, biodiversity conservation and restoration have been high priorities for ... (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GRECCO, SIMONE S.; COSTA-SILVA, THAIS A.; JERZ, GEROLD; DE SOUSA, FERNANDA S.; LONDERO, VINICIUS S.; GALUPPO, MARIANA K.; LIMA, MARTA L.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; TEMPONE, ANDRE G.; et al. Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages. Chemico-Biological Interactions, v. 277, p. 55-61, NOV 1 2017. (15/50075-2, 15/11936-2, 13/50228-8)

FERREIRA, DAIANE D.; SOUSA, FERNANDA S.; COSTA-SILVA, THAIS A.; REIMAO, JULIANA Q.; TORRECILHAS, ANA C.; JOHNS, DEIDRE M.; SEAR, CLAIRE E.; HONORIO, KATHIA M.; LAGO, JOAO HENRIQUE G.; ANDERSON, EDWARD A.; et al. Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 176, p. 162-174, AUG 15 2019. (15/50075-2, 18/10279-6, 18/07885-1, 16/24524-7)

AMARAL, MAIARA; DE SOUSA, FERNANDA S.; SILVA, THAIS A. COSTA; JUNIOR, ANDRES JIMENEZ G.; TANIWAKI, NOEMI N.; JOHNS, DEID RE M.; LAGO, JOAO HENRIQUE G.; ANDERSON, EDWARD A.; TEMPONE, ANDRE G.. A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division. SCIENTIFIC REPORTS, v. 9, APR 16 2019. (15/50075-2, 18/10279-6, 18/07885-1)

BAPTISTA CANUTO, GISELE ANDRE; DORR, FABIANE; GHILARDI LAGO, JOAO HENRIQUE; TEMPONE, ANDRE GUSTAVO; PINTO, ERNANI; PIMENTA, DANIEL CARVALHO; SIMON FARAH, JOAO PEDRO; MANSO ALVES, MARIA JULIA; MAGGI TAVARES, MARINA FRANCO. New insights into the mechanistic action of methyldehydrodieugenol B towards Leishmania (L.) infantum via a multiplatform based untargeted metabolomics approach. METABOLOMICS, v. 13, n. 5, MAY 2017. (15/50075-2, 12/04601-6, 14/25494-9, 12/07361-6, 12/18756-1)

TEMPONE, ANDRE GUSTAVO; FERREIRA, DAIANE DIAS; LIMA, MARTA LOPES; COSTA SILVA, THAIS ALVES; BORBOREMA, SAMANTA E. T.; REIMAO, JULIANA QUERO; GALUPPO, MARIANA K.; GUERRA, JULIANA MARIOTTI; RUSSELL, ANGELIE J.; WYNNE, GRAHAM M.; et al. Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 139, p. 947-960, OCT 20 2017. (15/50075-2, 15/23403-9, 13/07275-5)