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Interelationship of body composition and early factors in lifespan in the Nutritionist Health Study: modulation by gut microbiota?


Brazilian population aging has contributed to raise mortality rate due to non-communicable diseases (NCDs). The aging process affects body composition causing reduction in muscle and bone mass and elevation in fat mass, mainly in visceral fat, and enhancing morbidity and mortality. Among NCDs, the atherosclerotic cardiovascular disease is the leader cause of mortality and, despite knowledge concerning its risk factors, these do not explain outcomes completely. In this scenario, comprehension about how events in early life could influence cardiometabolic health of adults has been searched. Knowledge on the importance of intra-utero environment and on the development plasticity has allowed identifying risk and/or etiopathogenetic factors early in life course, which may reverse in more effective preventive measures. Scientific interest on the impact of maternal nutrition on the concept, breast feeding and nutritional status after birth has been addressed to the body composition, particularly the fat mass, based on its involvement in the genesis of metabolic diseases and atherosclerosis. The role of alterations in muscle mass on the cardiometabolic risk has been scarcely investigated. Recently, it was recognized that cardiometabolic profile is modulated by the gut microbiota and mediated by inflammation. The follow-up of a young population as that of the NutriHS is of great interest in order to examine associations of early life factors with body composition and cardiometabolic risk. This study investigates whether the exposure to certain pre- and post-birth nutrition conditions would be associated with body composition, traditional cardiovascular risk factors and novel biomarkers in young adults. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ESHRIQUI, ILANA; FOLCHETTI, LUCIANA DIAS; VALENTE, ANGELICA MARQUES MARTINS; DE ALMEIDA-PITITTO, BIANCA; FERREIRA, SANDRA ROBERTA G.. Breastfeeding duration is associated with offspring's adherence to prudent dietary pattern in adulthood: results from the Nutritionist's Health Study. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, v. 11, n. 2, p. 136-145, . (15/10045-7, 17/13087-8)
ESHRIQUI, ILANA; VALENTE, ANGELICA MARQUES MARTINS; FOLCHETTI, LUCIANA DIAS; DE ALMEIDA-PITITTO, BIANCA; FERREIRA, SANDRA ROBERTA G.. Pre-pregnancy BMI is associated with offspring body composition in adulthood before adiposity-related disorders: a retrospective cohort. PUBLIC HEALTH NUTRITION, v. 24, n. 6, p. 1296-1303, . (15/10045-7, 17/13087-8)
LUTHOLD, RENATA V.; FERNANDES, GABRIEL R.; CAROLINA FRANCO-DE-MORAES, ANA; FOLCHETTI, LUCIANA G. D.; FERREIRA, SANDRA ROBERTA G.. Gut microbiota interactions with the immunomodulatory role of vitamin D in normal individuals. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 69, p. 76-86, . (15/10045-7)
VALENTE, ANGELICA MARQUES MARTINS; DE ALMEIDA-PITITTO, BIANCA; ARCHANJO FERRARO, ALEXANDRE; DIAS FOLCHETTI, LUCIANA G.; TANDE SILVA, ISIS; FERREIRA, SANDRA ROBERTA G.. Birth weight associated with dual energy X-ray absorptiometry-determined muscle-bone unit in young healthy women from the Nutritionists' Health Study. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, v. 12, n. 1, p. 42-49, . (15/10045-7, 17/13087-8)

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