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Interelationship of body composition and early factors in lifespan in the Nutritionist Health Study: modulation by gut microbiota?

Grant number: 15/10045-7
Support type:Regular Research Grants
Duration: December 01, 2015 - January 31, 2018
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Sandra Roberta Gouvea Ferreira Vivolo
Grantee:Sandra Roberta Gouvea Ferreira Vivolo
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Bianca de Almeida Pititto ; Ligia Araujo Martini ; Marle dos Santos Alvarenga


Brazilian population aging has contributed to raise mortality rate due to non-communicable diseases (NCDs). The aging process affects body composition causing reduction in muscle and bone mass and elevation in fat mass, mainly in visceral fat, and enhancing morbidity and mortality. Among NCDs, the atherosclerotic cardiovascular disease is the leader cause of mortality and, despite knowledge concerning its risk factors, these do not explain outcomes completely. In this scenario, comprehension about how events in early life could influence cardiometabolic health of adults has been searched. Knowledge on the importance of intra-utero environment and on the development plasticity has allowed identifying risk and/or etiopathogenetic factors early in life course, which may reverse in more effective preventive measures. Scientific interest on the impact of maternal nutrition on the concept, breast feeding and nutritional status after birth has been addressed to the body composition, particularly the fat mass, based on its involvement in the genesis of metabolic diseases and atherosclerosis. The role of alterations in muscle mass on the cardiometabolic risk has been scarcely investigated. Recently, it was recognized that cardiometabolic profile is modulated by the gut microbiota and mediated by inflammation. The follow-up of a young population as that of the NutriHS is of great interest in order to examine associations of early life factors with body composition and cardiometabolic risk. This study investigates whether the exposure to certain pre- and post-birth nutrition conditions would be associated with body composition, traditional cardiovascular risk factors and novel biomarkers in young adults. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
Study points to link between vitamin D and profile of gut microbiota 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ESHRIQUI, ILANA; FOLCHETTI, LUCIANA DIAS; VALENTE, ANGELICA MARQUES MARTINS; DE ALMEIDA-PITITTO, BIANCA; FERREIRA, SANDRA ROBERTA G. Breastfeeding duration is associated with offspring's adherence to prudent dietary pattern in adulthood: results from the Nutritionist's Health Study. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, v. 11, n. 2, p. 136-145, APR 2020. Web of Science Citations: 2.
LUTHOLD, RENATA V.; FERNANDES, GABRIEL R.; CAROLINA FRANCO-DE-MORAES, ANA; FOLCHETTI, LUCIANA G. D.; FERREIRA, SANDRA ROBERTA G. Gut microbiota interactions with the immunomodulatory role of vitamin D in normal individuals. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 69, p. 76-86, APR 2017. Web of Science Citations: 40.

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