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Extracellular matrix in different types of mammalian placentation

Grant number: 15/22350-9
Support Opportunities:Research Grants - Visiting Researcher Grant - International
Duration: February 12, 2016 - February 09, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Reproduction
Principal Investigator:Maria Angelica Miglino
Grantee:Maria Angelica Miglino
Visiting researcher: Andrea Mess
Visiting researcher institution: Leibniz Universität Hannover, Germany
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Most recently, regenerative medicine resulted in therapeutic innovations and new horizons in regard to tissue engineering and organ/tissue transplants. Interestingly, the mammalian placenta represented a promising source of bioactive, decellularized material for tissue engineering purposes, containing a rich extracellular matrix with hormones, cytokines, collagen, enzymes, anticoagulant proteins, antioxidant and growth factors that are largely genetically similar to the fetus. In order to better understand the potential values of the placental extracellular matrix for purposes of regenerative medicine and tissue engineering, we will conduct a comparative approach of the principal role, form and function as well as the genetic background of the extracellular matrix in selected models of placental invasivenes, i.e. the guinea pig (or the mouse) for haemochorial, the dog for endotheliochorial and the bovine/cow for epitheliochorial placentas. The main questions to be addressed are structural similarities and differences of these types in regard to the establishment and nature of an extracellular placental matrix, their acellular and bioactive components as well as the associated responses to recoloniasation with stem cells and the potential applications in tissue engineering. We will apply methods of functional morphology including traditional histology for understanding the general interaction of important components, immunohistochemistry especially in regard to stem cell markers and markers for the most important bio-components such as catenins, connexins, integrins and metalloproteinases as well as electron-microscopy for fine-structure analyzes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NUNES BARRETO, RODRIGO DA SILVA; ROMAGNOLLI, PATRICIA; MESS, ANDREA MARIA; MIGLINO, MARIA ANGELICA. Decellularized bovine cotyledons may serve as biological scaffolds with preserved vascular arrangement. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v. 12, n. 4, p. E1880-E1888, . (15/22350-9, 15/14535-9)
FAVARON, PHELIPE O.; BORGHESI, JESSICA; MESS, ANDREA MARIA; CASTELUCCI, PATRICIA; MATIAS, GUSTAVO DE SA SCHIAVO; NUNES BARRETO, RODRIGO DA SILVA; MIGLINO, MARIA ANGELICA. Establishment of 3-dimensional scaffolds from hemochorial placentas. Placenta, v. 81, p. 32-41, . (15/22350-9)

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